Dosage form containing multiple drugs
First Claim
1. A pharmaceutical dosage form comprising (a) a first drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines, and (b) a second drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines, wherein the dosage form provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug.
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Abstract
A pharmaceutical dosage form comprising a first drug and a second drug, both of which are selected from decongestants, antitussives, expectorants, analgesics and antihistamines. The dosage form provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
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Citations
156 Claims
- 1. A pharmaceutical dosage form comprising (a) a first drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines, and (b) a second drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines, wherein the dosage form provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug.
- 70. A bi-layered tablet which comprises a first layer and a second layer, the first layer comprising a first drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines, and the second layer comprising a second drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines and is different from the first drug, wherein the bi-layered tablet provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the bi-layered tablet provides a plasma concentration within a therapeutic range of the first drug.
- 81. A multi-layered tablet which comprises at least a first layer and a second layer, wherein the first layer comprises a first drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines and the second layer is a controlled release layer and comprises a second drug which is selected from decongestants, antitussives, expectorants, analgesics and antihistamines and is different from the first drug.
- 88. A pharmaceutical dosage form which comprises (a) a first drug which is selected from antihistamines and has a first plasma half-life and (b) a second drug which is selected from decongestants, antitussives, analgesics and expectorants and has a second plasma half-life that differs from the first plasma half-life by at least about 3 hours, wherein the dosage form provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 80% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug.
- 114. A pharmaceutical dosage form comprising (a) a first drug which is selected from decongestants, antitussives, expectorants and analgesics, and (b) a second drug which is selected from decongestants, antitussives, expectorants and analgesics and is different from the first drug, wherein the dosage form provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug and wherein the dosage form is substantially free of antihistamines.
- 144. A bi-layered tablet which comprises a first layer and a second layer, the first layer comprising a first drug which is selected from decongestants, antitussives, expectorants and analgesics, and the second layer comprising a second drug which is different from the first drug and is selected from decongestants, antitussives, expectorants and analgesics, wherein the bi-layered tablet provides a plasma concentration within a therapeutic range of the second drug over a period which is coextensive with at least about 70% of a period over which the bi-layered tablet provides a plasma concentration within a therapeutic range of the first drug and wherein the bi-layered tablet is substantially free of antihistamines.
Specification