Antifouling heparin coatings
First Claim
1. A medical device comprising a biocompatible polymer and heparin, wherein heparin is attached to the polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein, and wherein heparin can be molecular heparin, a fragment of heparin, or a derivative thereof.
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Accused Products
Abstract
A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
167 Citations
36 Claims
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1. A medical device comprising a biocompatible polymer and heparin,
wherein heparin is attached to the polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein, and wherein heparin can be molecular heparin, a fragment of heparin, or a derivative thereof.
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15. A polymeric composition comprising a biocompatible polymer and heparin,
wherein heparin is attached to the polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein, and wherein heparin can be molecular heparin, a fragment of heparin, or a derivative thereof.
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31. A method of making a polymeric composition comprising a biocompatible polymer and heparin, comprising:
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providing a biocompatible polymer which is optionally functionalized, providing heparin which is optionally functionalized, and coupling heparin to the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein, wherein heparin can be molecular heparin, a fragment of heparin, or a derivative thereof. - View Dependent Claims (32, 33, 34, 35, 36)
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Specification