Resorbable delivery systems for the treatment of cancer
First Claim
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1. A composition for the controlled release of an antineoplastic agent and an immunostimulant comprising an antineoplastic agent and an immunostimulant dispersed throughout a matrix wherein said composition is the hydration reaction product of an aqueous mixture comprised of:
- an inorganic compound capable of undergoing hydration and/or crystallization, an antineoplastic agent, an immunostimulant, and at least one of;
a matrix polymer, a complexing agent, and a conditioning agent.
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Abstract
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of anti-cancer agents. Advantageously, the inorganic used is calcium sulfate. The invention also includes novel methods of treating cancer.
1 Citation
68 Claims
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1. A composition for the controlled release of an antineoplastic agent and an immunostimulant comprising an antineoplastic agent and an immunostimulant dispersed throughout a matrix wherein said composition is the hydration reaction product of an aqueous mixture comprised of:
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an inorganic compound capable of undergoing hydration and/or crystallization, an antineoplastic agent, an immunostimulant, and at least one of;
a matrix polymer, a complexing agent, and a conditioning agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A composition for the controlled release of cisplatin and GM-CSF comprising cisplatin and GM-CSF dispersed throughout a calcium sulfate dihydrate matrix wherein said composition is the hydration reaction product of an aqueous mixture comprised of:
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calcium sulfate hemihydrate, cisplatin, GM-CSF, and a matrix polymer.
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13. A composition for the controlled release of a radiation potentiator comprising a radiation potentiator dispersed throughout a matrix wherein said composition is the hydration reaction product of an aqueous mixture comprised of:
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an inorganic compound capable of undergoing hydration and/or crystallization, a radiation potentiator, and at least one of;
a matrix polymer, a complexing agent, and a conditioning agent. - View Dependent Claims (14, 15, 16, 18)
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17. A composition for the controlled release of paclitaxel comprising paclitaxel dispersed throughout a calcium sulfate dihydrate matrix wherein said composition is the hydration reaction product of an aqueous mixture comprised of:
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calcium sulfate hemihydrate, paclitaxel, and a matrix polymer.
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19. A method of treating a solid tumor in a mammal comprising:
administering to said mammal a resorbable delivery system for sustained release of i) an antineoplastic agent and ii) an immunostimulant - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of treating a solid tumor in a mammal comprising:
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a) administering to said mammal a resorbable delivery system for sustained release of a radiation potentiator, and b) irradiating said tumor. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54, 55, 56, 57, 58)
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53. A method as in claim wherein said tumor is selected from the group consisting of prostate, breast, bladder, brain, head and neck tumors.
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59. A method of treating a tumor in a mammal comprising:
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a) treating ex vivo tumor cells from said mammal with an antineoplastic agent, and b) administering to said mammal said tumor cells treated in step a) and c) administering to said mammal a resorbable delivery system for sustained release of an immunostimulant. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68)
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Specification