Resorbable matrices with coatings for delivery of bioactive compounds
First Claim
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1. A composition for the controlled release of an active agent comprising an active agent and a matrix polymer dispersed throughout a matrix having a coating wherein said matrix is the hydration reaction product of an aqueous mixture comprised of:
- an inorganic compound capable of undergoing hydration and/or crystallization, and a matrix polymer, wherein said inorganic compound of said matrix becomes a solid by hydration and/or crystallization.
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Abstract
This invention relates to the production and use of coated inorganic-biopolymer complexes for the controlled release of bioactive compounds including medicinals. Advantageously, the delivery system compositions include an inorganic, a matrix polymer, and a coating. Advantageously, the inorganic used is calcium sulfate.
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Citations
44 Claims
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1. A composition for the controlled release of an active agent comprising an active agent and a matrix polymer dispersed throughout a matrix having a coating wherein said matrix is the hydration reaction product of an aqueous mixture comprised of:
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an inorganic compound capable of undergoing hydration and/or crystallization, and a matrix polymer, wherein said inorganic compound of said matrix becomes a solid by hydration and/or crystallization. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method of producing a composition for the controlled release of an active agent comprising:
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(a) mixing an active agent, an inorganic compound capable of undergoing hydration and/or crystallization, and a matrix biopolymer, and (b) drying the product of step (a) and (c) coating the product of step (b). - View Dependent Claims (43, 44)
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Specification