Method and apparatus for testing for presence or absence of select biological substances
First Claim
1. A fluid flow test device comprising:
- a first strip of aqueous wicking material on which is deposited at a first delivery time an aqueous biological sample to be tested for the presence or absence of a target material;
a second strip of aqueous wicking material having a test site that contains a capture material that binds to the target material, the second strip being in fluid communication with the first strip of aqueous wicking material at a first location upstream of the test site;
a visual label material that is wicked along the second strip of material from a location upstream of the test site to the test site beginning at a predetermined point in time after the first delivery time.
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Accused Products
Abstract
A fluid flow test device comprising: a chromatography path of aqueous wicking material on which is deposited at an upstream site at a selected delivery time an aqueous biological sample to be tested for the presence or absence of a target material; a capture material bound to the wicking material at a test site downstream of the upstream site, the capture material having a functionality that binds to a first locus on the target material upon wicking of the target material downstream to the test site; a visual label material having a functionality that binds to a second locus on the target material, the chromatography path having a site upstream of the test site at which the visual label material is begun to wick at a predetermined point in time after the first delivery time such that the visual label material does not intermix with the aqueous biological sample within the chromatography path.
48 Citations
27 Claims
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1. A fluid flow test device comprising:
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a first strip of aqueous wicking material on which is deposited at a first delivery time an aqueous biological sample to be tested for the presence or absence of a target material;
a second strip of aqueous wicking material having a test site that contains a capture material that binds to the target material, the second strip being in fluid communication with the first strip of aqueous wicking material at a first location upstream of the test site;
a visual label material that is wicked along the second strip of material from a location upstream of the test site to the test site beginning at a predetermined point in time after the first delivery time. - View Dependent Claims (2, 3, 4, 5)
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6. Method of testing for the presence or absence of a target material in an aqueous biological sample, comprising:
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delivering the aqueous biological sample to a first strip of aqueous wicking material at a first selected delivery time;
providing a second strip of aqueous wicking material having a selected capture material stationarily located at a test site, the capture material being capable of binding to the target material, the first strip of material being in fluid communication with the second strip at a first selected location on the second strip that is upstream of the test site;
delivering a visual label material to the second strip of material upstream of the test site, the visual label material being delivered to the second strip of material at a second predetermined point in time after the first selected delivery time. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. Method of testing for the presence or absence of a target material in an aqueous biological sample, comprising:
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binding a selected capture material to a test site on a strip of aqueous wicking material at a location downstream of a selected application site on the strip, the capture material being capable of binding to the selected target material;
delivering the aqueous biological sample to the selected application site at a first selected delivery time, and allowing the biological sample to be wicked downstream toward the test site;
delivering a visual label material to the strip of material at a location upstream of the test site for downstream wicking of the visual label material to the test site, the visual label material being delivered to the strip of aqueous wicking material at a second predetermined point in time that occurs after the first selected delivery time. - View Dependent Claims (14, 15, 16, 17, 18)
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19. A fluid flow test device comprising:
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a first strip of aqueous wicking material on which is deposited at a first delivery time an aqueous biological sample to be tested for the presence or absence of a target material;
a second strip of aqueous wicking material having a test site that contains a capture material that binds to the target material, the second strip being in fluid communication with the first strip of aqueous wicking material at a first location upstream of the test site;
a third strip of aqueous wicking material in fluid flow communication with the second strip at a second location upstream of the test site, a visual label material being deposited on the third strip for wicking along the second strip of material to the test site. - View Dependent Claims (20, 21, 22, 23, 24)
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25. A fluid flow test device comprising:
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a chromatography path of aqueous wicking material on which is deposited at an upstream site at a selected delivery time an aqueous biological sample to be tested for the presence or absence of a target material;
a capture material bound to the wicking material at a test site downstream of the upstream site, the capture material having a functionality that binds to a first locus on the target material upon wicking of the target material downstream to the test site;
a visual label material having a functionality that binds to a second locus on the target material, the chromatography path having a site upstream of the test site at which the visual label material is begun to wick at a predetermined point in time after the first delivery time such that the visual label material does not intermix with the aqueous biological sample within the chromatography path. - View Dependent Claims (26, 27)
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Specification