Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of disease
First Claim
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1. A method of preventing metastasis of a cellular proliferative disease comprising the step of administering to a subject in need thereof a therapeutically effective amount of a 750,000 to 1,500,000 dalton hyaluronan
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Abstract
This application provides methods and compositions for the treatment of cancer. The application provides compositions comprising hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
70 Citations
56 Claims
- 1. A method of preventing metastasis of a cellular proliferative disease comprising the step of administering to a subject in need thereof a therapeutically effective amount of a 750,000 to 1,500,000 dalton hyaluronan
- 13. A method of treating a cellular proliferative disease comprising the step of orally or parenterally administering to a subject in need thereof a therapeutically effective amount of a composition comprising a 750,000 to 1,500,000 dalton hyaluronan and a chemotherapeutic agent.
- 24. A method of treating a drug resistant disease in a subject in need thereof comprising the step of orally or parenterally administering to said subject a therapeutically effective amount of a 750,000 to 1,500,000 dalton hyaluronan in conjunction with a chemotherapeutic agent.
- 35. A pharmaceutical composition comprising a therapeutically effective amount of an anticancer agent or a derivative thereof and hyaluronic acid.
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41. A method of treating a patient with cancer comprising the administration of a therapeutically effective amount of an anticancer agent, or a derivative thereof and hyaluronic acid to a patient in need of such treatment.
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42. A method of treating a patient with cancer comprising the administration of a therapeutically effective amount of Camptosar®
- (CPT
11) or a derivative thereof and hyaluronic acid to a patient in need of such treatment. - View Dependent Claims (43, 44, 45, 46, 47, 48)
- (CPT
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49. A method of treating a subject having colorectal cancer comprising:
- administering to said subject a composition comprising hyaluronic acid and an effective amount of Camptosar®
(CPT
11) or a derivative thereof, thereby treating the subject. - View Dependent Claims (50, 51, 52, 53, 54, 55)
- administering to said subject a composition comprising hyaluronic acid and an effective amount of Camptosar®
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56. A method of treating a subject having colorectal cancer comprising:
- administering to said subject a composition comprising hyaluronic acid having a molecular weight of 850,00 daltons at a concentration of about 25 mg/kg to about 100 mg/kg and an effective amount of Camptosar®
(CPT
11) or a derivative thereof at a concentration of 50 mg/kg, thereby treating the subject.
- administering to said subject a composition comprising hyaluronic acid having a molecular weight of 850,00 daltons at a concentration of about 25 mg/kg to about 100 mg/kg and an effective amount of Camptosar®
Specification