Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
First Claim
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1. A method of treating or inhibiting sexual dysfunction in a human or other mammal subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a dually acting compound capable of inhibiting neutral endopeptidase and human soluble endopeptidase.
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Abstract
The present invention relates to the novel medicinal use of dually acting compounds capable of inhibiting neutral endopeptidase (=NEP) and human soluble endopeptidase (=hSEP) in the prophylaxis and/or treatment of sexual dysfunction in mammals and humans.
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Citations
16 Claims
- 1. A method of treating or inhibiting sexual dysfunction in a human or other mammal subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a dually acting compound capable of inhibiting neutral endopeptidase and human soluble endopeptidase.
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9. A pharmaceutical combination composition comprising pharmacologically effective quantities of:
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a) at least one neutral endopeptidase inhibitor, b) at least one inhibitor of human soluble endopeptidase, and c) at least one compound selected from the group consisting of PDE5 inhibitors, NPY receptor antagonists, PDE2 inhibitors, nitric oxide donors, dopamine receptor agonists, melanocortin receptor agonists, potassium channel openers, calcium activated potassium channel openers, α
1-adrenoceptor antagonists, VIP receptor agonists, VIP analogues, α
2-adrenoceptor antagonists, estrogens, medroxyprogesterone, medroxyprogesterone acetate, methyl testosterone hormone replacement therapy agents, testosterone, testostrone replacement agents, testosterone/oestradiol agents, estrogen agonists, serotonin receptor agonists, serotonin receptor antagonists, prostanoid receptor agonists, purinergic receptor agonists, ECE inhibitors, endothelin receptor antagonists, NEP inhibitors and antidepressant agents. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A kit comprising a plurality of separate containers in a single package, said containers containing pharmaceutical compositions for use in combination and comprising:
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a1) in one separate container a pharmaceutical composition comprising at least one neutral endopeptidase inhibitor and in a second separate container a pharmaceutical composition comprising at least one inhibitor of human soluble endopeptidase, or a2) in one separate container a pharmaceutical composition comprising a dually acting compound capable of inhibiting neutral endopeptidase and human soluble endopeptidase, and b) in another separate container a pharmaceutical composition comprising at least one compound supportive to the inventive use which is selected from the group consiting of PDE5 inhibitors, NPY receptor antagonists, PDE2 inhibitors, nitric oxide donors, dopamine receptor agonists, melanocortin receptor agonists, potassium channel openers, calcium activated potassium channel openers, α
1-adrenoceptor antagonists, VIP receptor agonists or VIP analogues, α
2-adrenoceptor antagonists, estrogens, medroxyprogesterone, medroxyprogesterone acetate, methyl testosterone hormone replacement therapy agents, testosterone, testostrone replacement agents, testosterone/estradiol agents, estrogen agonists, serotonin receptor agonists, serotonin receptor antagonists, prostanoid receptor agonists, purinergic receptor agonists, ECE inhibitors, endothelin receptor antagonists, NEP inhibitors and antidepressant agents.
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16. A method of treating or inhibiting sexual dysfunction in mammals and humans comprising administering to a subject in need thereof therapeutically effective amounts of
a) at least one neutral endopeptidase inhibitor, b) at least one inhibitor of human soluble endopeptidase, and c) at least one compound supportive to the inventive use which is selected from the group consisting of PDE5 inhibitors, NPY receptor antagonists, PDE2 inhibitors, nitric oxide donors, dopamine receptor agonists, melanocortin receptor agonists, potassium channel openers, calcium activated potassium channel openers, α - 1-adrenoceptor antagonists, VIP receptor agonists or VIP analogues, α
2-adrenoceptor antagonists, estrogens, medroxyprogesterone, medroxyprogesterone acetate, methyl testosterone hormone replacement therapy agents, testosterone, testostrone replacement agents, testosterone/oestradiol agents, estrogen agonists, serotonin receptor agonists, serotonin receptor antagonists, prostanoid receptor agonists, purinergic receptor agonists, ECE inhibitors, endothelin receptor antagonists, NEP inhibitors and antidepressant agents.
- 1-adrenoceptor antagonists, VIP receptor agonists or VIP analogues, α
Specification