Amino ceramide-like compounds and therapeutic methods of use
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Abstract
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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Citations
16 Claims
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1-12. -12. (canceled)
- 13. A pharmaceutical composition comprising a compound represented by the following structural formula:
- 15. A pharmaceutical composition comprising a compound represented by the structural formula:
Specification