Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
First Claim
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12. A method for treating a neuropsychiatric disorder in a mammalian subject, comprising administering an effective amount of a composition comprising a Na+K+2Cl co-transporter antagonist to the subject.
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Abstract
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na+—K+-2Cl− (NKCC) cotransporter. In certain embodiments, the Na+—K+-2Cl− co-transporter is NKCC1.
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19 Claims
- 12. A method for treating a neuropsychiatric disorder in a mammalian subject, comprising administering an effective amount of a composition comprising a Na+K+2Cl co-transporter antagonist to the subject.
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13-1. The method of claim 12, wherein the Na+K+2Cl co-transporter antagonist is a NKCC1 co-transporter antagonist.
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