Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
First Claim
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1. A pharmaceutical composition comprising in combination a pharmacologically effective quantity of each of a) at least one NEP-inhibitor, b) at least one inhibitor of the endogenous endothelin producing system, and c) at least one PDE V inhibitor.
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Abstract
A combination therapy for the inhibition and/or treatment of sexual dysfunction and/or cardiovascular diseases in humans and other mammals, by administering a synergistic combination of at least one inhibitor of neutral endopeptidase, at least one inhibitor of the endogenous endothelin producing system, and at least one inhibitor of phosphodiesterase 5.
31 Citations
30 Claims
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1. A pharmaceutical composition comprising in combination a pharmacologically effective quantity of each of
a) at least one NEP-inhibitor, b) at least one inhibitor of the endogenous endothelin producing system, and c) at least one PDE V inhibitor.
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19. A method of treating or inhibiting an endothelial dysfunction in a human or other mammal subject in need thereof, said method comprising administering to said subject an effective amount of a combination of (a) at least one neutral endopeptidase inhibitor, (b) at least one inhibitor of the endogenous endothelin producing system, and (c) at least one PDE V inhibitor.
- 20. A method of treating or inhibiting a sexual dysfunction in a human or other mammal subject in need thereof, said method comprising administering to said subject an effective amount of a combination of at least one neutral endopeptidase inhibitor, at least one inhibitor of the endogenous endothelin producing system, and at least one PDE V inhibitor.
- 25. A method of treating or inhibiting a cardiovascular disease in a human or other mammal subject in need thereof, said method comprising administering to said subject an effective amount of a combination of at least one neutral endopeptidase inhibitor, at least one inhibitor of the endogenous endothelin producing system, and at least one PDE V inhibitor.
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29. A kit comprising in separate containers in a single package pharmaceutical dosage forms for use in combination, comprising:
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i1) in one separate container a pharmaceutical dosage form comprising at least one neutral endopeptidase inhibitor and in a second separate container a pharmaceutical dosage form comprising at least one inhibitor of the endogenous endothelin producing system, or i2) in one separate container a pharmaceutical dosage form comprising a dually acting compound capable of inhibiting neutral endopeptidase and the endogenous endothelin producing system, and ii) in another separate container a pharmaceutical dosage form comprising at least one PDE V inhibitor. - View Dependent Claims (30)
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Specification