Noninvasive analyzer sample probe interface method and apparatus
First Claim
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1. A method for noninvasive estimation of a tissue sample property, comprising the steps of:
- providing an analyzer, wherein said analyzer comprises;
a sample probe coupled to said analyzer, said sample probe being movable with respect to said analyzer, and said sample probe having a tip;
displacing at least a portion of said tissue sample with said sample probe;
collecting a set of time serial spectral data of said tissue sample at least during said step of displacing;
selecting a sub-set of said set of spectra, wherein sampling precision is enhanced; and
estimating said tissue sample property using said sub-set.
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Abstract
A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
119 Citations
61 Claims
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1. A method for noninvasive estimation of a tissue sample property, comprising the steps of:
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providing an analyzer, wherein said analyzer comprises;
a sample probe coupled to said analyzer, said sample probe being movable with respect to said analyzer, and said sample probe having a tip;
displacing at least a portion of said tissue sample with said sample probe;
collecting a set of time serial spectral data of said tissue sample at least during said step of displacing;
selecting a sub-set of said set of spectra, wherein sampling precision is enhanced; and
estimating said tissue sample property using said sub-set. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for determining a blood/tissue analyte concentration, comprising the steps of:
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providing a noninvasive analyzer, comprising;
a sample probe, wherein at least part of said sample probe is movable relative to said analyzer;
iteratively collecting a positioning spectrum at a first rate;
using at least a portion of said positioning spectrum to establish contact of said sample probe with said tissue;
collecting a set of spectra at a second rate; and
using at least a portion of said set of spectra to estimate said analyte property. - View Dependent Claims (23, 24)
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25. A method for noninvasive sampling for estimation of a tissue analyte property, comprising the steps of:
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providing an analyzer, wherein said analyzer comprises;
a sample probe coupled to said analyzer;
translating along a z-axis at least a portion of said sample probe relative to said tissue sample;
collecting a set of time serial spectral data at least during said step of translating said sample probe relative to said tissue sample;
extracting a feature from said set of spectral data; and
estimating a tissue sample property using said extracted feature. - View Dependent Claims (26)
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27. An apparatus for spectroscopic noninvasive measurement of a tissue sample, comprising:
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a noninvasive analyzer;
a sample probe coupled to said analyzer;
means for moving at least part of said sample probe along any of x-, y-, and z-axes;
means for acquisition of at least one spectrum while said sample probe is moving; and
at least one algorithm for analysis of said spectrum, wherein said at least one algorithm provides for iterative control of said means for moving and said means for acquisition of said spectrum. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A method for noninvasive sampling using a sample probe attached to an analyzer for estimation of a tissue analyte property, comprising the steps of:
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moving at least a portion of said sample probe relative to said tissue;
collecting a noninvasive spectrum of said tissue using said sample probe and said analyzer;
analyzing said spectrum to create any of;
a feature; and
a metric;
either of repeating said steps of moving, collecting, and analyzing based upon any of said metric or said feature;
or estimating said tissue analyte property using at least said spectrum. - View Dependent Claims (47, 48, 49, 50)
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51. A method for noninvasive sampling using a sample probe attached to an analyzer for estimation of a tissue analyte property, comprising the steps of:
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moving at least a portion of said sample probe relative to said tissue at a first rate;
moving at least a portion of said sample probe relative to said tissue at a second rate;
collecting a noninvasive spectrum of said tissue using said sample probe and said analyzer, wherein said step of collecting occurs at least partially during said step of moving said sample probe at said second rate;
either of repeating said preceding steps;
or estimating said tissue analyte property using at least said spectrum. - View Dependent Claims (52)
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53. A method for analyte property estimation of a tissue sample, comprising the steps of:
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providing an analyzer, comprising;
a sample probe having a sample probe tip;
dispensing a coupling fluid on said tissue sample;
iteratively controlling z-axis movement of said sample probe tip relative to said tissue sample to contact said sample probe tip with said coupling fluid;
collecting at least one noninvasive spectrum of said tissue sample using said sample probe and said analyzer; and
estimating said analyte property using said noninvasive spectrum. - View Dependent Claims (54, 55, 56)
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57. An apparatus for spectroscopic noninvasive measurement of a tissue sample, comprising:
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a noninvasive analyzer;
a sample probe coupled to said analyzer;
means for moving at least part of said sample probe along at least one of x-, y-, and z-axes;
means for acquisition of at least one spectrum while said sample probe is moving; and
an algorithm for analysis of said spectrum, wherein said algorithm provides iterative control of said means for moving and said means for acquisition of said spectrum.
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58. A method for estimation of a sample tissue property, comprising the steps of:
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providing a near-infrared noninvasive analyzer;
providing a sample probe coupled to said analyzer;
displacing said tissue with said sample probe;
collecting a set of time serial spectral data of said tissue sample during said step of displacing; and
estimating said tissue property using dynamic tissue response captured in said set of spectra during said steps of displacing and collecting. - View Dependent Claims (59, 60)
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61. An apparatus for minimizing sampling error of noninvasive estimation of a tissue analyte property, comprising:
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a dynamic probe movable in at least one of x-, y-, and z-axes relative to said tissue;
means for measuring spectra of the tissue with said probe while said probe moves in at least one of said axes; and
means for estimating said analyte property using said spectra.
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Specification