Device for the endovascular treatment of intracranial aneurysms

• US 20050267510A1
• Filed: 05/26/2004
• Published: 12/01/2005
• Est. Priority Date: 05/26/2004
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Razack, Nasser
• Application Number:
  US10/854,293
• Publication Number:
  US 20050267510A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12163 having a string of elements connected to each other
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids

Abstract

A method and device for intravascular treatment of various vascular and intravascular issues, such as aneurysms, is disclosed. The device generally includes a multiple member, bead strand or device that includes a plurality of members interconnected with one another in a substantially flexible manner. The device may be positioned through a catheter or micro-catheter substantially intravascularly to occlude or embolize an aneurysm to substantially eliminate the possibility of perforation or rupture of the aneurysm.

Claims

1. An embolization system comprising:

a flexible conduit;

a plurality of spherical functional units disposed at spaced intervals along said flexible conduit; and

a hydrogel solution carried by each of said plurality of spherical functional units.

2. The embolization system of claim 1 wherein each of said spherical functional units comprises a wire-frame cage structure, said wire-frame cage structure defining an internal cavity.

3. The embolization system of claim 2 wherein said internal cavity is adapted to receive said hydrogel solution.

4. The embolization system of claim 1 wherein said spherical functional units comprise a solid metallic ball.

5. The embolization system of claim 4 wherein said solid metallic ball is coated with said hydrogel solution.

6. The embolization system of claim 1 wherein said spherical functional units comprise a hydrogel foam structure.

7. The embolization system of claim 1 wherein said conduit includes a length between about 0.39 inches and about 19.69 inches (10 mm and 500 mm).

8. The embolization system of claim 1 wherein said spherical functional units include an outside diameter substantially equal to about 0.018 inches (0.46 mm).

9. The embolization system of claim 1 wherein said spherical functional units include an outside diameter substantially equal to about 0.014 inches (0.36 mm).

10. The embolization system of claim 1 wherein said flexible conduit includes at least one detachment zone, said at least one detachment zone operable to allow said flexible conduit to separate at said at least one detachment zone to achieve a desired length of said flexible conduit.

11. An embolization system comprising:

a plurality of spherical functional units, said plurality of spherical functional units each defining an internal cavity;

a flexible conduit fixedly supporting said plurality of spherical functional units, said flexible conduit extending through said internal cavity of each of said spherical units; and

a hydrogel solution disposed within said internal cavity of each of said plurality of spherical functional units.

12. The embolization system of claim 11 wherein said spherical functional units include a surface defining each of said spherical functional units.

13. The embolization system of claim 12 wherein said surface defines a pore;

wherein said hydrogel solution is operable to exit said internal cavity.

14. The embolization system of claim 11 wherein said hydrogel solution is substantially hydrophilic and operable to expand when exposed to an environment.

15. The embolization system of claim 11 wherein said spherical functional units include a diameter of about 0.01 inches (0.25 mm) to about 0.02 inches (0.51 mm).

16. The embolization system of claim 11, further comprising:

a coil unit.

17. The embolization system of claim 16 wherein said coil is coated with said hydrogel solution.

18. The embolization system of claim 11 wherein said plurality of spherical functional units are substantially positionable relative to each of the other of said spherical functional units.

19. An embolization system for substantially obstructing an aneurysm, comprising:

a first member disposable relative to the aneurysm;

a second member disposable relative to the aneurysm; and

a connection member interconnecting said first member and said second member;

wherein said first member and said second member are moveable relative to one another via said connection member for implantation of said first member and said second member.

20. The embolization system of claim 19 wherein said first member and said second member are substantially similar and selected from a group comprising a hollow member, a solid member, a porous member, and combinations thereof.

21. The embolization system of claim 19 wherein said first member and said second member include a plurality of said first and said second members interconnected to substantially form a flexible system to substantially fill a volume.

22. The embolization system of claim 19 wherein at least one of said first member and said second member include a substantially porous surface, wherein a material positioned in said first member or said second member is exposed to an environment in which said first member or said second member are placed.

23. The embolization system of claim 22 wherein said porous surface is substantially defined by a woven strand forming a woven configuration such that a surface of said first member or said second member includes a pore defined by said woven strand;

wherein said pore is operable to expose an interior portion of said first member or said second member to an environment.

24. The embolization system of claim 22 wherein a hydrogel is included in said first member or said second member;

wherein said hydrogel expands at a selected rate upon introduction into an anatomical position.

25. The embolization system of claim 19 wherein said connection member interconnects a plurality of said first members and said second members, and said connection member substantially passes through each of said plurality of said first members and said second members.

26. The embolization system of claim 19 wherein said connection member interconnects said first member and said second member by passing through said first member and said second member, such that said first member and said second member are substantially moveable relative to said connection member and each other.

27. The embolization system of claim 19 wherein said first member and said second member includes an external geometry selected from a group comprising a sphere, a rectangle, an octagon, an oval, or combinations thereof.

28. The embolization system of claim 19, further comprising a bioactive material.

29. The embolization system of claim 19 wherein said first member or said second member include an external dimension of about 0.01 inches (0.25 mm) to about 0.02 inches (0.51 mm).

30. A method of providing an embolization system to a vascular region including an expanding element, comprising:

providing a package including a volume;

placing an expanding element in said volume;

providing a bore in said package such that said expanding element is operable to interact with an environment surrounding said package; and

guiding said package to the vascular region.

31. The method of claim 30 wherein providing said package includes:

forming a substantial sphere from a member that is woven to form said bore between portions of said member;

wherein said woven sphere defines said volume.

32. The method of claim 30 wherein placing an expanding element includes providing a hydrogel operable to expand at least six times in volume in an environment of the vascular region.

33. The method of claim 30, further comprising:

interconnecting a plurality of said packages;

moving said plurality of packages into the vascular region; and

filling the vascular region with a selected geometry of said plurality of packages.

34. The method of claim 33 wherein said plurality of said packages are operable to be positioned in a selected geometry substantially freely.

35. The method of claim 30 wherein guiding said package includes passing said package through a catheter.

36. The method of claim 35 wherein passing said package through said catheter includes moving said package with a hydrological force.

37. An embolization system comprising:

a flexible conduit;

a plurality of spherical functional units disposed at spaced intervals along said flexible conduit; and

a bioabsorbable polymer carried by each of said plurality of spherical functional units.

38. The embolization system of claim 37 wherein said bioabsorbable polymer is a polyglycolic acid.

39. The embolization system of claim 37 wherein said bioabsorbable polymer is a polylactic acid.