Drug eluting implants to prevent cardiac apoptosis
First Claim
1. An implantable device configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site.
1 Assignment
0 Petitions
Accused Products
Abstract
Implantable devices are configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site in or near the heart. The implantable devices include, but are not limited to, leads, stents, heart valves, atrial septal defect devices, cardiac patches and ventricular restraint devices. Depending on the composition of the device, the drug may be carried by the device through a coating applied to the device, or may be included in the device during the device manufacturing process. The drug may also be included in microparticles, such a microspheres, that are delivered locally through a conduit, such as a catheter.
290 Citations
24 Claims
- 1. An implantable device configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site.
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20. A system for providing local delivery of an anti-apoptotic drug to a local delivery area, said device comprising:
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an implantable drug delivery conduit adapted to be positioned at or near the local delivery area;
a reservoir of microparticles carrying an anti-apoptotic drug, the reservoir in fluid communication with the drug delivery conduit; and
a pump for transferring the microparticles from the reservoir into the conduit for delivery at the local delivery area. - View Dependent Claims (21)
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22. A method of treating an ischemic or infarcted region of a heart comprising:
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medicating an implantable device with an anti-apoptotic drug; and
positioning the implantable device at or near the infarcted region. - View Dependent Claims (23, 24)
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Specification