Multiple dose condensation aerosol devices and methods of forming condensation aerosols
First Claim
Patent Images
2. A device for producing a condensation aerosol in an airflow comprising:
- an airway comprising an inlet, and an outlet;
at least one support disposed within the airway;
a substance disposed on each of the at least one support; and
a mechanism configured to vaporize the substance from each of the at least one support;
wherein an airflow passing from the inlet to the outlet is directed to each of the at least one support such that the substance forms condensation aerosol particles that are entrained in the airflow when vaporized.
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Accused Products
Abstract
Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.
363 Citations
89 Claims
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2. A device for producing a condensation aerosol in an airflow comprising:
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an airway comprising an inlet, and an outlet;
at least one support disposed within the airway;
a substance disposed on each of the at least one support; and
a mechanism configured to vaporize the substance from each of the at least one support;
wherein an airflow passing from the inlet to the outlet is directed to each of the at least one support such that the substance forms condensation aerosol particles that are entrained in the airflow when vaporized. - View Dependent Claims (3)
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4. A device for producing a condensation aerosol in an airflow comprising:
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an airway comprising an inlet, and an outlet;
a plurality of supports disposed within the airway;
a substance disposed on at least one support of the plurality of supports; and
a mechanism configured to vaporize the substance from each support of the plurality of supports wherein the substance is disposed;
wherein an airflow passing from the inlet to the outlet is directed to the supports wherein the substance is disposed such that the substance forms condensation aerosol particles that are entrained in the airflow when vaporized. - View Dependent Claims (5, 6, 7)
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- 8. An electrically resistive heating element comprising a metal foil for vaporizing a substance disposed thereon to produce a condensation aerosol comprising the substance.
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33. A device for delivering a condensation aerosol comprising a substance to a subject comprising:
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a housing;
an airway contained within the housing comprising an inlet, and an outlet;
a mouthpiece coupled to the outlet;
at least one support disposed within the airway;
the substance disposed on the at least one support;
a mechanism configured to vaporize the substance;
a power source for powering the mechanism configured to vaporize the substance; and
an actuation mechanism configured to transfer energy from the power source to the mechanism configured to vaporize the substance;
wherein an airflow from the inlet to the outlet of the airway causes the substance to vaporize and condense in the airflow to form a condensation aerosol. - View Dependent Claims (34)
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35. A device for delivering a condensation aerosol comprising a substance to a subject comprising:
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a dispensing unit comprising;
a first housing comprising a receptacle for a separable cartridge;
a controller for controlling vaporization of the substance; and
a power source; and
a separable cartridge comprising;
a second housing;
an airway contained within the housing having an inlet, and an outlet;
a mouthpiece coupled to the outlet;
at least one electrically resistive heating element disposed within the airway;
the substance disposed on the at least heating element; and
an actuation mechanism configured to transfer energy from the power source to the at least one heating element;
wherein an airflow from the inlet to the outlet of the airway causes the substance to vaporize and condense in the airflow to form a condensation aerosol. - View Dependent Claims (36)
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37. A device for delivering a condensation aerosol comprising a substance to a subject comprising:
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a dispensing unit comprising;
a first housing comprising a receptacle for a separable cartridge;
a controller for controlling vaporization of the substance; and
a power source; and
a separable cartridge comprising;
a second housing;
an airway contained within the housing having an inlet, and an outlet;
a mouthpiece coupled to the outlet;
a plurality of electrically resistive heating elements disposed within the airway;
the substance disposed on at least one electrically resistive heating element of the plurality of electrically resistive heating elements; and
an actuation mechanism configured to transfer energy from the power source to each of the electrically resistive heating elements of the plurality of electrically resistive heating elements, which have a substance disposed thereon;
wherein an airflow from the inlet to the outlet of the airway causes the substance to vaporize and condense in the airflow to form a condensation aerosol. - View Dependent Claims (1, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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77. A method of entraining a substance within an airflow comprising:
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providing an airflow in an airway comprising an inlet and an outlet;
providing at plurality of supports disposed within the airway, wherein the substance is disposed on at least one support of the plurality of supports;
releasing the substance from the support into the airflow;
wherein an airflow passing from the inlet to the outlet is directed to the support on which the substance is disposed such that the substance is entrained in the airflow when released from the support. - View Dependent Claims (78)
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79. A method of producing a condensation aerosol in an airflow comprising:
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providing an airflow in an airway comprising an inlet and an outlet;
providing a plurality of supports disposed within the airway, wherein the substance is disposed on at least one support of the plurality of supports; and
vaporizing the substance from the support into the airflow;
wherein an airflow passing from the inlet to the outlet is directed to the support on which the substance is disposed such that the substance forms a condensation aerosol when vaporized.
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82-1. The method of claim 80, wherein the condensation aerosol is administered to the respiratory tract of the subject.
Specification