Subcutaneous analyte sensor
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Accused Products
Abstract
Assembly and method for measuring the concentration of an analyte in a biological matrix. The assembly includes an implantable optical-sensing element that comprises a body, and a membrane mounted on the body in a manner such that the membrane and the body define a cavity. The membrane is permeable to the analyte, but is impermeable to background species in the biological matrix. A refractive, element is positioned in the cavity. A light source transmits light of a first intensity onto the refractive element, and a light detector receives light of a second intensity that is reflected from the cavity. A controller device optically coupled to the detector compares the first and second light intensities, and relates the intensities to analyte concentration.
208 Citations
52 Claims
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1-32. -32. (canceled)
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33. An implantable optical-sensing element suitable for measuring the concentration of an analyte in a biological matrix, said optical-sensing element comprising:
a body;
a membrane mounted on said body such that said body and said membrane define a cavity for receiving said analyte, said membrane being substantially permeable to said analyte, and substantially impermeable to background species in said biological matrix; and
a refractive-element disposed in said cavity, said refractive element having a refractive index different from a refractive index of said analyte.- View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
Specification