Apparatus and method for transdermal delivery of multiple vaccines
First Claim
1. A system for transdermally delivering multiple immunologically active agents, comprising a microprojection array having a plurality of stratum corneum-piercing microprojections, said microprojection array having at least first and second array regions, said first array region having a first biocompatible coating disposed thereon, said second array region having a second biocompatible coating disposed thereon, wherein said first biocompatible coating includes at least one immunologically active agent.
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Accused Products
Abstract
An apparatus and method for transdermally delivering an immunologically active agent comprising a delivery system having a microprojection array that includes a plurality of microprojections that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, the microprojection array having a plurality of array regions, each of the array regions having a different biocompatible coating disposed thereon, wherein at least one of the array region coatings includes an immunologically active agent. In one embodiment, each coating on the array regions includes a different immunologically active agent. In another embodiment, the biocompatible coating on a first array region includes an immunologically active agent and the biocompatible coating on a second array region includes an immune response augmenting adjuvant.
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Citations
38 Claims
- 1. A system for transdermally delivering multiple immunologically active agents, comprising a microprojection array having a plurality of stratum corneum-piercing microprojections, said microprojection array having at least first and second array regions, said first array region having a first biocompatible coating disposed thereon, said second array region having a second biocompatible coating disposed thereon, wherein said first biocompatible coating includes at least one immunologically active agent.
- 28. A system for transdermally delivering multiple immunologically active agents, comprising a microprojection array having a plurality of stratum corneum-piercing microprojections, said microprojection array having at least first and second array regions, said first array region having a first biocompatible coating disposed thereon, said first biocompatible coating including a first immunologically active agent, said second array region having a second biocompatible coating disposed thereon, said second biocompatible coating including a second immunologically active agent.
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36. A method for transdermally delivering multiple immunologically active agents to a subject, the method comprising the steps of:
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providing a microprojection array having a plurality of microprojections, said microprojection array having at least first and second array regions;
coating said first array region with a first biocompatible coating, said first biocompatible coating including at least one immunologically active agent;
coating said second array region with a second biocompatible coating, said second biocompatible coating including an immune response augmenting adjuvant; and
applying said coated microprojection array to the skin of a subject.
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37. A method for transdermally delivering multiple immunologically active agents to a subject, the method comprising the steps of:
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providing a microprojection array having a plurality of microprojections, said microprojection array having a plurality of array regions;
coating at least a first microprojection in a first array region with a first biocompatible coating having a first immunologically active agent;
coating at least a second microprojection in a second array region with a second biocompatible coating having a second immunologically active agent; and
applying said coated microprojection array to the skin of a subject. - View Dependent Claims (38)
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Specification