Intraductal treatment targeting methylated promoters in breast cancer

• US 20050272685A1
• Filed: 08/15/2005
• Published: 12/08/2005
• Est. Priority Date: 03/30/2001
• Status: Abandoned Application

• Current Assignee: Susan Love
• Original Assignee: Susan Love
• Inventors: Hung, David
• Application Number:
  US11/203,800
• Publication Number:
  US 20050272685A1
• Time in Patent Office: Days
• US Class Current: 514/44.R
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention provides compositions for targeting methylated promoters in breast cancer and pre-cancer patients. The invention also provides methods for intraductal treatment of breast cancer and pre-cancer patients by delivering intraductally an agent that targets methylated promosters of silenced genes.

Claims

1-11. -11. (canceled)

12. A method for inhibiting DNA methylation of breast cancer genes in a patient having premalignant or malignant breast duct epithelial cells in a breast duct, the method comprising:

delivering a composition into the breast duct of the patient, said composition comprising an inhibitor of DNA methylation and a biocompatible solution suitable as a vehicle for delivering the inhibitor of DNA methylation into the breast duct of the patient;

thereby inhibiting DNA methylation of breast cancer-related genes within said premalignant or malignant breast duct epithelial cells.

14. The method of claim 12 wherein the breast cancer genes are selected from the group consisting of cyclin D2, RARbeta2, twist, BRCA1, maspin, estrogen receptor, progesterone receptor, e-cadherin, p16 (INK4a), P15 (INK4b), P14 (ARF), death associated protein (DAP), retinoblastoma Rb, and vonHippel-Lindaur (VHL) gene.

21. The method of claim 12 wherein the biocompatible solution is selected from the group consisting of saline, viscous material, and gel material.

13. (canceled)

15. (canceled)

16. (canceled)

19. (canceled)

20. (canceled)