Use of alkylureas for treating acne

• US 20050272819A1
• Filed: 02/02/2005
• Published: 12/08/2005
• Est. Priority Date: 07/31/2003
• Status: Abandoned Application

• Current Assignee: Albert Einstein College of Medicine (Yeshiva University)
• Original Assignee: Albert Einstein College of Medicine (Yeshiva University)
• Inventors: Rubinstein, Arye
• Application Number:
  US11/049,377
• Publication Number:
  US 20050272819A1
• Time in Patent Office: Days
• US Class Current: 514/588
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61P 17/10 Anti-acne agents

Abstract

Methods of treating acne are provided. The methods involve applying to the acne an alkyl urea in a pharmaceutically acceptable carrier. The use of an alkyl urea in the manufacture of a medicament for the treatment of acne is also provided. Compositions of alkyl ureas in a pharmaceutically acceptable carrier are additionally provided.

Claims

1. A method of treating acne on the skin of a patient, the method comprising applying to the acne an alkyl urea in a pharmaceutically acceptable carrier at a concentration and for a time sufficient to reduce the acne,

wherein the alkyl urea has the formula R—

HN—

CO—

NH₂, where R is a monovalent alkane of 1-12 carbon atoms.

2. The method of claim 1, wherein R has 1-8 carbon atoms.

3. The method of claim 1, wherein the alkyl urea is butyl urea.

4. The method of claim 1, wherein the alkyl urea is at a concentration of 0.1 molar to 0.5 molar.

5. Use of an alkyl urea for the manufacture of a medicament for the treatment of acne, wherein the alkyl urea has the formula R—

HN—

CO—

NH₂, where R is a monovalent alkane of 1-12 carbon atoms.

6. The use of claim 5, wherein R has 1-8 carbon atoms.

7. The use of claim 5, wherein the alkyl urea is butyl urea.

8. The use of claim 5, wherein the alkyl urea is at a concentration of 0.1 molar to 0.5 molar.

9. An alkyl urea in a pharmaceutically acceptable carrier, at a concentration useful for the treatment of acne, wherein the alkyl urea has the formula R—

HN—

CO—

NH₂, where R is a monovalent alkane of 1-12 carbon atoms.

10. The alkyl urea of claim 9, wherein R has 1-8 carbon atoms.

11. The alkyl urea of claim 9, wherein the alkyl urea is butyl urea.

12. The alkyl urea of claim 9, wherein the alkyl urea is at a concentration of 0.1 molar to 0.5 molar.

13. The alkyl urea of claim 9, wherein the carrier is selected from the group consisting of distilled water, a polar organic solvent, a cream, a gel, and a liposome.