Method for delivering drugs to the adventitia using device having microprojections

• US 20050273075A1
• Filed: 06/08/2004
• Published: 12/08/2005
• Est. Priority Date: 06/08/2004
• Status: Abandoned Application

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Krulevitch, Peter, Maghribi, Mariam
• Application Number:
  US10/863,043
• Publication Number:
  US 20050273075A1
• Time in Patent Office: Days
• US Class Current: 604/509
• CPC Class Codes: A61M 2025/0093 wherein at least one needle is a microneedle
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A method for delivering a therapeutic agent into tissue includes providing a device for delivering a therapeutic agent into tissue. The device has an elongated body; a first balloon in the body expandable from a collapsed position to an expanded position; a second balloon in the body expandable from a collapsed position to an expanded position. The second balloon has a plurality of apertures therein; and a therapeutic agent is located in the second balloon. A plurality of microprojections are located on a surface of the second balloon for penetrating tissue. Upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures. The device is placed adjacent a site in the tissue; and the therapeutic agent is delivered into the tissue at the site by expanding the first balloon from the collapsed position to the expanded position.

Claims

1. A method for delivering a therapeutic agent into tissue, the method comprising the steps of:

providing a device for delivering a therapeutic agent into tissue, the device comprising;

an elongated body;

a first balloon in the body expandable from a collapsed position to an expanded position;

a second balloon in the body expandable from a collapsed position to an expanded position, the second balloon having a plurality of apertures therein;

a therapeutic agent in the second balloon; and

a plurality of microprojections on a surface of the second balloon for penetrating tissue; and

wherein upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures;

placing the device adjacent a site in the tissue; and

delivering the therapeutic agent into the tissue at the site by expanding the first balloon from the collapsed position to the expanded position.

2. The method according to claim 1, further comprising expanding the first balloon by providing a first fluid medium into the first balloon.

12. The method according to claim 1 further comprising placing the catheter within the vessel prior to delivering the therapeutic agent into the wall of the vessel.

13. The method according to claim 12, further comprising delivering the therapeutic agent into a layer of the vessel.

14. The method according to claim 13, further comprising delivering the therapeutic agent into the adventitial layer of the vessel.

3. A method for delivering a therapeutic agent into a wall of a vessel, the method comprising the steps of:

providing a device for delivering a therapeutic agent into tissue, the device comprising;

an elongated body;

a first balloon in the body expandable from a collapsed position to an expanded position;

a second balloon in the body expandable from a collapsed position to an expanded position, the second balloon having a plurality of apertures therein;

a therapeutic agent in the second balloon; and

a plurality of microprojections on a surface of the second balloon for penetrating tissue; and

wherein upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures;

placing the device adjacent a site in the wall of the vessel; and

delivering the therapeutic agent into the wall of the vessel at the site by expanding the first balloon from the collapsed position to the expanded position.

4. The method according to claim 3, further comprising expanding the first balloon by providing a first fluid medium into the first balloon.

5. The method according to claim 4, further comprising placing the device within the vessel prior to delivering the therapeutic agent into the wall of the vessel.

6. The method according to claim 5, further comprising delivering the therapeutic agent into a layer of the vessel.

7. The method according to claim 6, further comprising delivering the therapeutic agent into the adventitial layer of the vessel.

8. A method for delivering a therapeutic agent into tissue, the method comprising the steps of:

providing a catheter for delivering a therapeutic agent into tissue, the catheter comprising;

an elongated body;

a first balloon in the body expandable from a collapsed position to an expanded position;

a second balloon in the body expandable from a collapsed position to an expanded position, the second balloon having a plurality of apertures therein;

a therapeutic agent in the second balloon; and

a plurality of microprojections on a surface of the second balloon for penetrating tissue; and

wherein upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures;

placing the catheter adjacent a site in the tissue; and

delivering the therapeutic agent into the tissue at the site by expanding the first balloon from the collapsed position to the expanded position.

9. The method according to claim 8, further comprising expanding the first balloon by providing a first fluid medium into the first balloon.

10. A method for delivering a therapeutic agent into a wall of a vessel, the method comprising the steps of:

providing a catheter for delivering a therapeutic agent into tissue, the catheter comprising;

an elongated body;

a first balloon in the body expandable from a collapsed position to an expanded position;

a second balloon in the body expandable from a collapsed position to an expanded position, the second balloon having a plurality of apertures therein;

a therapeutic agent in the second balloon; and

a plurality of microprojections on a surface of the second balloon for penetrating tissue; and

wherein upon expansion of the first balloon from the collapsed position to the expanded position, the second balloon is expanded from the collapsed position to the expanded position for deploying the plurality of microprojections into tissue and for dispensing the therapeutic agent from the second balloon into the tissue through the plurality of apertures;

placing the catheter adjacent a site in the wall of the vessel; and

delivering the therapeutic agent into the wall of the vessel at the site by expanding the first balloon from the collapsed position to the expanded position.

11. The method according to claim 10, further comprising expanding the first balloon by providing a first fluid medium into the first balloon.