Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy
First Claim
1. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:
- (a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
(b) providing antibodies or antibody fragments or other targeting moieties labeled with at least one radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
(c) introducing the radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
(d) waiting for at least some of the radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
(e) arranging the transmission head proximate to at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head passes through and warms at least the radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
(f) transmitting the RF signal via the transmission head, thereby warming the radiometal-labeled monoclonal antibodies bound to target cells; and
(g) receiving at least a portion of the RF signal that passed through the patient.
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Accused Products
Abstract
A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
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Citations
42 Claims
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1. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
(b) providing antibodies or antibody fragments or other targeting moieties labeled with at least one radiometal suitable for radiotherapy and characterized by targeting a target biomolecule of at least one of the target cells;
(c) introducing the radiometal-labeled antibodies or antibody fragments or other targeting moieties into the patient;
(d) waiting for at least some of the radiometal-labeled antibodies or antibody fragments or other targeting moieties to bind to some of the target cells;
(e) arranging the transmission head proximate to at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head passes through and warms at least the radiometal-labeled antibodies or antibody fragments or other targeting moieties bound to target cells;
(f) transmitting the RF signal via the transmission head, thereby warming the radiometal-labeled monoclonal antibodies bound to target cells; and
(g) receiving at least a portion of the RF signal that passed through the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 39, 40, 41, 42)
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23. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating a hyperthermia-inducing RF signal having at least the one frequency for transmission via the transmission head;
(b) providing biomolecules labeled with at least one radionuclide and characterized by targeting a target biomolecule of at least one of the target cells;
(c) introducing the radionuclide-labeled biomolecules into the patient;
(d) providing targeted RF absorption enhancers characterized by binding to the target cells to thereby increase heating of target cells responsive to the RF signal by interaction between the RF signal and the targeted RF absorption enhancer;
(e) introducing the targeted RF absorption enhancers into the patient;
(f) waiting for at least some of the radionuclide-labeled biomolecules to bind to some of the target cells;
(g) arranging the transmission head proximate to at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head passes through and warms at least the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells;
(h) transmitting the RF signal via the transmission head, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells; and
(i) receiving at least a portion of the RF signal that passed through the patient. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification