Method of treating diabetes mellitus in a patient
First Claim
1. A method of delivering insulin to the lungs of a human patient, the method comprising:
- a. providing an individual dosage of insulin in dry powder form; and
b. delivering the individual dosage to the human patient in aerosolized form so that the insulin is delivered to the alveolar region of the lungs of the human patient.
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Accused Products
Abstract
Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.
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Citations
14 Claims
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1. A method of delivering insulin to the lungs of a human patient, the method comprising:
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a. providing an individual dosage of insulin in dry powder form; and
b. delivering the individual dosage to the human patient in aerosolized form so that the insulin is delivered to the alveolar region of the lungs of the human patient.
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2. A method of treating diabetes in a patient that is incapable of maintaining a normal blood glucose level because the patient is suffering from diabetes, the method comprising:
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a. providing a dosage of dry insulin powder containing between 2 and 300 units of insulin;
b. delivering into the patient'"'"'s circulatory system between 1 and 30 units of insulin by pulmonary transport of the dry insulin powder across the alveolar region of the patient'"'"'s lungs;
thereby maintaining an acceptable blood glucose level in the patient.
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3. A method of treating diabetes in a patient in need of such treatment, the method comprising the steps of:
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a. providing a dose of dry insulin powder in the range of 2 to 300 units;
wherein the dry powder comprises particles of less than 10 microns in size;
b. aerosolizing the dry powder;
c. delivering the aerosolized dry powder to the alveolar region of the patient'"'"'s lungs for pulmonary transport into the patient'"'"'s circulatory system;
d. wherein the amount of insulin absorbed is sufficient for the patient to maintain an acceptable blood glucose level.
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4. A method of delivering insulin to the lungs of a human patient, the method comprising the steps of:
b. delivering the individual dosage to the patient in aerosolized form so that the insulin is delivered to the lungs of the patient in a controlled amount, and is absorbed into the patient'"'"'s circulatory system. - View Dependent Claims (5, 6, 7, 8, 9, 11, 12, 13, 14)
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10. A method of treating diabetes in a patient comprising the steps of:
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a. providing a dose of dry insulin powder in the range of about 1 to 300 units;
wherein the dry powder comprises particles between about 0.5 and 12 microns in size;
b. aerosolizing the dry powder; and
c. delivering the aerosolized dry powder to the lungs of the patient for pulmonary transport into the patient'"'"'s circulatory system.
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Specification