Molecularly imprinted phosphate binders for therapeutic use
First Claim
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1. A molecularly imprinted polymer (MIP) compound comprising:
- a) a polymer, electrostatically imprinted with a phosphate, comprising at least one monomer exhibiting an affinity for phosphate ions, phosphate containing molecules, or a combination of both, at least one cross-linking agent for structurally supporting the at least one monomer, and a plurality of binding sites for binding to phosphate ions, phosphate containing molecules, or a combination of both, wherein the binding sites are accessible by pores;
or b) a polymer, electrostatically imprinted with a phosphate, comprising at least one monomer exhibiting an affinity for phosphate ions, phosphate containing molecules, or a combination of both, at least one cross-linking agent for structurally supporting the at least one monomer, and a plurality of binding sites for binding to phosphate ions, phosphate containing molecules, or a combination of both, wherein the binding sites are accessible by pores, and a physical spacer.
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Abstract
Methods for synthesizing molecularly imprinted polymers (MIP) having an affinity for dietary phosphates, resulting polymers, pharmaceutical compositions and modes of administration are disclosed. The MIP compounds are useful for binding excess dietary phosphates in a patient in need thereof.
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24 Claims
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1. A molecularly imprinted polymer (MIP) compound comprising:
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a) a polymer, electrostatically imprinted with a phosphate, comprising at least one monomer exhibiting an affinity for phosphate ions, phosphate containing molecules, or a combination of both, at least one cross-linking agent for structurally supporting the at least one monomer, and a plurality of binding sites for binding to phosphate ions, phosphate containing molecules, or a combination of both, wherein the binding sites are accessible by pores;
orb) a polymer, electrostatically imprinted with a phosphate, comprising at least one monomer exhibiting an affinity for phosphate ions, phosphate containing molecules, or a combination of both, at least one cross-linking agent for structurally supporting the at least one monomer, and a plurality of binding sites for binding to phosphate ions, phosphate containing molecules, or a combination of both, wherein the binding sites are accessible by pores, and a physical spacer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification