Systems and methods for providing a stem cell bank

• US 20050276792A1
• Filed: 03/22/2005
• Published: 12/15/2005
• Est. Priority Date: 03/26/2004
• Status: Abandoned Application

• Current Assignee: Celularity, Inc.
• Original Assignee: Celularity, Inc.
• Inventors: Kaminski, Joseph K., Deibert, Mark H., Goodman, Chris B., Feingold, Barnett
• Application Number:
  US11/088,149
• Publication Number:
  US 20050276792A1
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: C12N 5/0605 Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
• CPC Class Codes: G16B 50/00 ICT programming tools or database systems specially adapted for bioinformatics
• CPC Class Codes: G16B 50/30 Data warehousing; Computing architectures
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 40/20 for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• CPC Class Codes: G16H 70/60 relating to pathologies

Abstract

Methods, computer systems, and computer program products for maintaining a stem cell registry comprising information about a plurality of stem cell units. A donor is enrolled in the stem cell registry. A stem cell unit from the donor is characterized. Information about the stem cell unit, obtained by the characterizing, is recorded in the stem cell registry. Computer readable media comprising a plurality of data records. One or more respective data records in the plurality of data records comprises (i) a collection identifier number that uniquely corresponds to a stem cell donation, (ii) a cord blood cell count associated with the stem cell donation, and (iii) a placenta blood cell count associated with the stem cell donation. Additional computer readable media comprising a plurality of data records. One or more respective data records in the plurality of data records comprises (i) a cord blood cell count associated with a stem cell donation, (ii) a placenta blood cell count associated with the stem cell donation, and (iii) an indication of at least two stem cell transplant units in the stem cell donation.

Claims

1-56. -56. (canceled)

57. A method of maintaining a stem cell registry, said method comprising:

enrolling a donor in said stem cell registry;

characterizing a plurality of stem cell units from said donor, wherein a source of a first stem cell unit in said plurality of stem cell units differs from a source of a second stem cell unit in said plurality of stem cell units; and

recording information about said plurality of stem cell units in said stem cell registry, wherein said information comprises an indication of at least one stem cell transplant unit in each stem cell unit in said plurality of stem cell units.

58. The method of claim 57 wherein each said at least one stem cell transplant unit comprises between 25×

10⁷ nucleated cells and 50×

10⁷ nucleated cells.

59. The method of claim 57 wherein each said at least one stem cell transplant unit comprises between 50×

10⁷ nucleated cells and 75×

10⁷ nucleated cells.

60. The method of claim 57 wherein each said at least one stem cell transplant unit comprises between 75×

10⁷ nucleated cells and 200×

10⁷ nucleated cells.

61. The method of claim 57, wherein said enrolling comprises storing donor identification information about said donor in said stem cell registry.

62. The method of claim 57 wherein the stem cell registry comprises information about a plurality of stem cell units, each stem cell unit comprising a plurality of stem cell transplant units, the method further comprising:

obtaining type information of a patient; and

searching through said plurality of stem cell units for a stem cell unit having type information that matches the type information of the patient, wherein

when a match is found between a stem cell unit in said plurality of stem cell units and said patient, the method further comprises;

(i) allocating a number of stem cell transplant units from a stem cell unit in the matching stem cell unit in said plurality of stem cell units to said patient; and

(ii) decrementing a number of stem cell transplant units in the stem cell unit of the matching stem cell unit available in the stem cell registry by the number of stem cell transplant units allocated to the patient.

63. The method of claim 62 wherein the number of stem cell transplant units from the matching stem cell unit allocated to said patient is a function of the number of nucleated stem cells in each allocated stem cell transplant unit.

64. The method of claim 63 wherein the number of stem cell transplant units from the matching stem cell unit allocated to said patient is a function of the number of nucleated stem cells in each allocated stem cell transplant unit and the weight of the patient.

65. The method of claim 64 wherein between 0.5×

10⁷ and 200×

10⁷ nucleated cells per kilogram of patient body weight are allocated to said patient.

66. The method of claim 64 wherein between 1×

10⁷ and 50×

10⁷ nucleated cells per kilogram of patient body weight are allocated to said patient.

67. The method of claim 62 wherein the number of stem cell transplant units from the matching stem cell unit allocated to said patient is a function of the number of nucleated stem cells in each allocated stem cell transplant unit, the age of the patient, and the weight of the patient.

68. The method of claim 57 wherein said donor is mammalian and wherein said first stem cell unit comprises placental stem cells obtained from a post-partum placenta of the donor that has been exsanguinated and perfused.

69. The method of claim 57 wherein the donor is human.

70. The method of claim 57 wherein said stem cell registry comprises information about at least 100 stem cell units.

71. The method of claim 57 wherein said stem cell registry comprises information about at least 1000 stem cell units.

72. The method of claim 57 wherein said characterizing comprises:

performing a nucleated cell count on a stem cell unit in said plurality of stem cell units,

performing a leukocyte count on a stem cell unit in said plurality of stem cell units,

performing a mononuclear cell count on a stem cell unit in said plurality of stem cell units,

performing a CD34-positive cell count on a stem cell unit in said plurality of stem cell units,

performing a CD3-positive cell count on a stem cell unit in said plurality of stem cell units,

performing a colony-forming cell assay on a stem cell unit in said plurality of stem cell units,

performing an infectious disease assay on a stem cell unit in said plurality of stem cell units, or

determining an HLA blood type of a stem cell unit in said plurality of placental stem cell units.

73. The method of claim 57, wherein said characterizing comprises separately characterizing each stem cell unit in said plurality of stem cell units.

74. The method of claim 57 wherein

said enrolling said donor in said stem cell registry comprises receiving a fee from said donor, the method further comprising:

receiving a request from said donor or a family member of said donor for a stem cell transplant unit in a stem cell unit in the plurality of stem cell units; and

allocating said stem cell transplant unit to said donor or said family member of said donor.

75. The method of claim 57 wherein said donor is mammalian and

said source of said first stem cell unit is a post-partum placenta of the donor that has been exsanguinated and perfused, and

said source of said second stem cell unit is the cord blood of said donor.

76. The method of claim 57 wherein

stem cells obtained from a post-partum placenta of the donor form one or more stem cell units in said plurality of stem cell units;

and

stem cells obtained from the cord blood of said donor form a different stem cell unit in said plurality of stem cell units.

77-132. -132. (canceled)