Phosphopeptide antigens associated with MHC molecules
First Claim
1. A method of identifying a cancer cell-specific phosphopeptide, said method comprising extracting peptides from said cancer cell, identifying phosphopeptides by microcapillary reversed phase high performance liquid chromatography tandem mass spectrometric analysis, and comparing the level of said phosphopeptide in said cancer cell, with the level of said phosphopeptide in an otherwise normal counterpart cell or tissue, wherein a higher level of said phosphopeptide in said cancer cell is an indication that said phosphopeptide is a cancer cell-specific phosphopeptide.
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Abstract
The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of cancer and/or used in therapeutics to treat cancer.
6 Citations
20 Claims
- 1. A method of identifying a cancer cell-specific phosphopeptide, said method comprising extracting peptides from said cancer cell, identifying phosphopeptides by microcapillary reversed phase high performance liquid chromatography tandem mass spectrometric analysis, and comparing the level of said phosphopeptide in said cancer cell, with the level of said phosphopeptide in an otherwise normal counterpart cell or tissue, wherein a higher level of said phosphopeptide in said cancer cell is an indication that said phosphopeptide is a cancer cell-specific phosphopeptide.
Specification