Three-dimensional coils for treatment of vascular aneurysms

• US 20050277978A1
• Filed: 06/09/2005
• Published: 12/15/2005
• Est. Priority Date: 06/09/2004
• Status: Abandoned Application

• Current Assignee: Stout Medical Group, L.P. (Alphatec Holdings Incorporated)
• Original Assignee: SECANT MEDICAL, LLC (Compagnie Generale DES Etablissements Michelin SCA)
• Inventors: Greenhalgh, E. Skott
• Application Number:
  US11/148,601
• Publication Number:
  US 20050277978A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids

Abstract

A coil for the treatment of vascular aneurysms is disclosed. The coil is formed from filamentary members interlaced to form a three-dimensional substrate. The substrate is deformable between a collapsed state wherein it fits within a catheter, and an expanded state, which it assumes once deployed from the catheter into the vascular aneurysm. The three-dimensional shapes of the substrate include flat sheets biased into a helix or a tubular forms biased into figure eight loops, helical loops or a sinusoid. Bioactive characteristics may be imparted to the coil through the use of coatings or materials that provoke a healing response in living tissue.

Claims

1. A coil for treatment of vascular aneurysms, said coil being deliverable into an aneurysm of a vascular vessel through a catheter, said coil comprising a plurality of flexible, resilient filamentary members interlaced with one another to form an elongated substrate, said filamentary members biasing said substrate into a three-dimensional expanded state, said interlaced filamentary members defining a plurality of interstices dispersed on said substrate providing sites for coagulation of blood thereon when said substrate is in the expanded state, said substrate being expandable from a collapsed state wherein said substrate fits within the catheter, to said expanded state wherein said substrate expands to substantially fill the aneurysm, said substrate assuming said expanded state upon release from said catheter into said aneurysm.

2. A coil according to claim 1, wherein said filamentary members are interlaced to form a substantially flat sheet biased into a helically shaped tube when in said expanded state.

3. A coil according to claim 2, wherein said filamentary members are interlaced by a technique selected from the group consisting of weaving, knitting and braiding.

4. A coil according to claim 3, wherein said filamentary members comprise first and second of said filamentary members, said first filamentary members having a high elastic modulus thereby providing resiliency for expansion of said substrate to said expanded state, said second filamentary members comprising a material that provokes a strong healing response in living tissue for promoting blood coagulation on said substrate.

5. A coil according to claim 3, wherein said filamentary members are coated with a compound that provokes a healing response in living tissue.

6. A coil according to claim 5, wherein said compound is selected from the group consisting of polypropylene, polylactic acid, polyglycolic acid, polyurethane, hydrogel, radioactive agents, thrombin and collagen.

7. A coil according to claim 1, wherein said substrate is substantially covered by a porous membrane attached to said filamentary members and being formed of non-woven fibrous tendrils, said tendrils being in overlapping and tangled relation to form additional interstices providing further sites for coagulation of blood thereon.

8. A coil according to claim 1, further comprising an anchor attached to said substrate, said anchor being formed of a material that provokes a healing response in living tissue, said anchor for attaching said substrate to said vascular vessel within said aneurysm.

9. A coil according to claim 8, wherein said anchor is attached to an end of said substrate.

10. A coil according to claim 8, wherein said anchor is formed from interlaced filamentary members.

11. A coil according to claim 1, wherein said substrate comprises a tube, said filamentary members being interlaced by braiding to form said tube.

12. A coil according to claim 11, wherein said braided tube comprises first and second of said filamentary members, said first filamentary members having a higher elastic modulus than said second filamentary members thereby providing resiliency for expansion of said substrate, said second filamentary members comprising a material that provokes a stronger healing response in living tissue than said first filamentary members for promoting blood coagulation on said substrate.

13. A coil according to claim 11, further comprising a coating for said filamentary members of a compound that provokes a healing response in living tissue.

14. A coil according to claim 11, further comprising an anchor attached to an end of said tube, said anchor being formed of a material that provokes a healing response in living tissue, said anchor attaching said end of said tube to said vascular vessel within said aneurysm.

15. A coil according to claim 14, wherein said anchor is formed from interlaced filamentary members.

16. A coil according to claim 11, wherein said tube is biased into a shape selected from the group consisting of a helix, a figure eight and a sinusoid.

17. A coil according to claim 11, wherein said tube is substantially covered by a porous membrane attached to said filamentary members and being formed of non-woven fibrous tendrils, said tendrils being in overlapping and tangled relation to form additional interstices providing further sites for coagulation of blood thereon.

18. A coil according to claim 1, wherein said substrate comprises a tube, said filamentary members being interlaced by knitting to form said tube.

19. A coil for treatment of vascular aneurysms, said coil being deliverable into an aneurysm of a vascular vessel through a catheter, said coil comprising a plurality of flexible, resilient filamentary members interwoven with one another to form an elongated, substantially flat substrate, said substrate being biased into a three-dimensional helical shape, said interwoven filamentary members defining a plurality of interstices on said substrate providing sites for coagulation of blood, said substrate being expandable from a collapsed state wherein said substrate interfits within said catheter, to an expanded state wherein said substrate expands to substantially fill said aneurysm, said substrate expanding upon release from said catheter into said aneurysm, an anchor being attached to said substrate, said anchor being formed of a material that provokes a healing response in living tissue, said anchor being attachable to said vascular vessel within said aneurysm.

20. A coil according to claim 19, wherein said substrate is substantially covered by a porous membrane attached to said filamentary members and being formed of non-woven fibrous tendrils, said tendrils being in overlapping and tangled relation to form additional interstices providing further sites for coagulation of blood thereon.

21. A coil for treatment of vascular aneurysms, said coil being deliverable into an aneurysm of a vascular vessel through a catheter, said coil comprising a plurality of flexible, resilient filamentary members interbraided with one another to form an elongated, tubular substrate, said substrate being biased into a three-dimensional shape, said interbraided filamentary members defining a plurality of interstices on said substrate providing sites for coagulation of blood thereon, said substrate being expandable from a collapsed state wherein said substrate interfits within said catheter, to an expanded state wherein said substrate expands to substantially fill said aneurysm, said substrate expanding upon release from said catheter into said aneurysm, an anchor being attached to an end of said substrate, said anchor being formed of a material that provokes a healing response in living tissue, said anchor serving to attach said end of said substrate to said vascular vessel within said aneurysm.

22. A coil according to claim 21, wherein said tubular substrate is biased into a shape selected from the group consisting of a helix, a figure eight and a sinusoid.

23. A coil according to claim 21, wherein said tubular substrate is substantially covered by a porous membrane formed of non-woven fibrous tendrils attached to said filamentary members, said tendrils being in overlapping and tangled relation to form additional interstices providing further sites for coagulation of blood thereon.