Collecting and analyzing sensed information as a trend of heart failure progression or regression

• US 20050277992A1
• Filed: 06/10/2004
• Published: 12/15/2005
• Est. Priority Date: 06/10/2004
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Koh, Steve, Bornzin, Gene A., Park, Euljoon
• Granted Patent: US 7,548,785 B2
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

An exemplary method includes selecting a cross-correlation frequency having an associated cross-correlation period, detecting and binning a heart rate in a heart rate bin, detecting and binning an activity state in an activity state bin, repeating the detecting and binning a heart rate and the detecting and binning an activity state during a cross-correlation period, and summing the products a bin count of the heart rate bins and a bin count of the activity state bins to provide a cross-correlation index for the cross-correlation period. Other exemplary algorithms, methods, devices, systems, etc., are also disclosed.

Claims

13. A method comprising:

detecting and binning a first physiological measure;

detecting and binning a second physiological measure;

repeating the detecting and binning one or more times; and

summing the products of the first physiological measure bins and the second physiological measure bins to provide a cross-correlation index.

14. The method of claim 13 wherein a relationship exists between the first physiological measure and the second physiological measure.

15. The method of claim 13 wherein a change in the cross-correlation index indicates a change in autonomic activity.

16. The method of claim 13 further comprising storing the cross-correlation index and subsequently downloading the stored cross-correlation index to another device.

17. The method of claim 13 further comprising plotting the cross-correlation index with one or more other cross-correlation indexes versus time.

18. The method of claim 13 wherein one of the physiological measures comprises heart rate.

19. The method of claim 13 wherein one of the physiological measures comprises activity.

20. The method of claim 13 further comprising adjusting a cardiac stimulation therapy based at least in part on the cross-correlation index.

21. An implantable stimulation device comprising control logic to sum the products of a bin count of first physiological measure bins and a bin count of second physiological measure bins to provide a cross-correlation index.

1. A method comprising:

detecting and binning heart rate values in a heart rate bin;

detecting and binning activity values in an activity bin;

repeating the detecting and binning one or more times; and

summing the products of the heart rate bins and the activity bins to provide a cross-correlation index.

2. The method of claim 1 further comprising detecting and binning during a cross-correlation period on the order of approximately 24 hours.

3. The method of claim 1 wherein the cross-correlation index increases in response to decreasing sympathetic activity or increasing parasympathetic activity.

4. The method of claim 1 wherein the cross-correlation index decreases in response to increasing sympathetic activity or decreasing parasympathetic activity.

5. The method of claim 1 wherein detecting a heart rate comprises sensing atrial events.

6. The method of claim 1 wherein detecting a heart rate includes sensing ventricular events.

7. The method of claim 1 wherein the detecting an activity value comprises sensing motion.

8. The method of claim 1 further comprising comparing the cross-correlation index to another cross-correlation index.

9. The method of claim 1 further comprising comparing the cross-correlation index to a limit.

10. The method of claim 1 wherein the detecting and binning is performed according to a cross-correlation frequency that comprises one or more time divisions of less than one day.

11. The method of claim 10 wherein the one or more time divisions comprise a time division selected from a group consisting of sleep time divisions, morning time divisions, afternoon time divisions, and evening time divisions.

12. The method of claim 10 further comprising determining a cross-correlation index for each time division.

22. The implantable stimulation device of claim 21 further comprising control logic to adjust a cardiac stimulation therapy based at least in part on the cross-correlation index.

23. The implantable stimulation device of claim 22 further comprising a pulse generator capable of delivering a cardiac stimulation pulse.

23-1. The implantable stimulation device of claim 21 further comprising a telemetry circuit capable of communicating the cross-correlation index to another device.

24. An implantable stimulation device comprising:

means for detecting and binning a first physiological measure in a first physiological measure bin;

means for detecting and binning a second physiological measure in a second physiological measure bin;

means for repeating the detecting and binning a first physiological measure and the detecting and binning a second physiological measure one or more times; and

means for summing the products of the first physiological measure bins and the second physiological measure bins to provide a cross-correlation index.