Stent designed for the delivery of therapeutic substance or other agents

• US 20050278016A1
• Filed: 08/16/2005
• Published: 12/15/2005
• Est. Priority Date: 11/30/2001
• Status: Active Grant

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Jansen, Lex P., Welsh, Greg P.
• Granted Patent: US 8,292,945 B2
• Time in Patent Office: Days
• US Class Current: 623/1.420
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2002/91566 connected trough to trough
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2250/0035 differing in release or diffusion time
• CPC Class Codes: A61F 2250/0036 differing in thickness
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A stent comprising a serpentine portion extending about the circumference of the stent, the serpentine portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween, at least one of the turns at the first end, at least one of the turns at the second end, at least one of the struts therebetween, or some combination thereof having a plurality of shaped recesses thereon.

Claims

1. A stent comprising a serpentine portion extending about the circumference of the stent, the serpentine portion having a first end and a second end, the serpentine portion having a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween, at least one of the turns at the first end, at least one of the turns at the second end, at least one of the struts therebetween, or some combination thereof having a plurality of shaped recesses thereon.

2. The stent of claim 1, wherein said shaped recesses are substantially circular.

3. The stent of claim 1, wherein a plurality of said struts have a plurality of shaped recesses thereon and a plurality of turns have a plurality of shaped recesses thereon.

4. The stent of claim 1, wherein each turn at each end of each serpentine portion has a plurality of shaped recesses thereon.

5. The stent of claim 1 having a plurality of shaped recesses having substantially circular and ellipsoid shapes.

6. The stent of claim 1, wherein each of said at least some of said turns at first end, each of said some of said turns at said second end, and each of said some of said struts have a plurality of shaped recesses thereon.

7. The stent of claim 6, wherein at least one shaped recess has a substantially circular shape.

8. The stent of claim 7, further comprising elongated ellipsoid shaped recesses.

9. The stent of claim 1, wherein at least one shaped recess contains a therapeutic agent.

10. The stent of claim 9, wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.

11. A stent comprising a serpentine portion extending about the circumference of the stent, the serpentine portion having a first end and a second end, the serpentine portion have a plurality of turns at the first end and a plurality of turns at the second end and struts extending therebetween wherein at least some of said struts have at least one shaped recess thereon, said shaped recess smaller in dimension than said struts while the turns are free of shaped recesses.

12. The stent of claim 11, wherein at least some of said turns at the first end, at least of the turns at the second turn, or some combination thereof have at least one shaped recess thereon.

13. The stent of claim 11, wherein said shaped recess is an elongated ellipsoid.

14. The stent of claim 11, wherein said shaped recess has a substantially circular shape.

15. The stent of claim 11, wherein said at least some of said struts have more than one shaped recess thereon.

16. The stent of claim 11, wherein said at least some of said turns at said first end, some of said turns at said second end, or some combination thereof have more than one shaped recess thereon.

17. The stent of claim 16, wherein said shaped recess has a substantially circular shape.

18. The stent of claim 17, further comprising elongated ellipsoid shaped recesses.

19. The stent of claim 11, wherein said at least one shaped recess contains a therapeutic agent.

20. The stent of claim 19, wherein said therapeutic agent is selected from the group consisting of genetic material, growth factors, antineoplastics, antimitotics, anti-inflammatories, antiplatelets, anticoagulants, antifibrins, antithrombins, antiproliferatives, antibiotics, antioxidants, and antiallergenic substances.