Medical device

• US 20050278020A1
• Filed: 05/24/2005
• Published: 12/15/2005
• Est. Priority Date: 04/08/2003
• Status: Abandoned Application

• Current Assignee: Biophan Technologies Incorporated
• Original Assignee: Biophan Technologies Incorporated
• Inventors: Wang, Xingwu, Greenwald, Howard J.
• Application Number:
  US11/136,630
• Publication Number:
  US 20050278020A1
• Time in Patent Office: Days
• US Class Current: 623/1.440
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles

Abstract

An implantable medical device comprised of a lumen. When the device is, at different points in time, exposed to two different radio frequency electromagnetic radiations, one of whose frequencies differs from the other by a factor of at least 1.5, at least 90 percent of each of the radio frequency electromagnetic radiations penetrates to the lumen of the device.

Claims

1. An implantable medical device comprised of a lumen, wherein:

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device,

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device,

wherein said first frequency and said second frequency differ from each other by a factor of at least about 1.5, at least one of such frequencies being 1.5 times as great as the other.

2. The implantable medical device as recited in claim 1, wherein at least 95 percent of said first radio frequency electromagnetic radiation penetrates to said lumen of said device.

3. The implantable medical device as recited in claim 2, wherein at least 95 percent of said second radio frequency electromagnetic radiation penetrates to said lumen of said device.

7. The implantable medical device as recited in claim 1, wherein said medical device is comprised of material with a dielectric constant of from about 1

8. The medical device as recited in claim 1, wherein said medical device has an inductance of from about 0.1 to about 5 nanohenries and a capacitance of from about 0.1 to about 10 nanofarads.

9. The medical device as recited in claim 8, wherein said medical device is a coated medical device comprised of a coating.

10. The medical device as recited in claim 9, wherein said coating is comprised of material with a conductivity of from about 10⁻

13 (ohm-meter)<sup>−

1</sup> to about 10⁸ (ohm-meter)<sup>−

1</sup>.

11. The medical device as recited in claim 9, wherein said coated assembly is comprised of a substrate and a coating disposed thereon, wherein said coating is comprised of magnetic particles with a particle size in the range of from about 3 to about 20 nanometer.

12. The medical device as recited in claim 9, wherein said coating has a relative permeability of at least 1.1 over the range of frequencies of from about 10 megahertz to about 200 megahertz, an increase of such relative permeability over such range of from about 1×

10<sup>−

14</sup> to about 1×

10<sup>−

6</sup> per hertz, and a magnetization, when measured at a direct current magnetic field of 2 Tesla, of from about 0.1 to about 10 electromagnetic units per cubic centimeter.

13. The medical device as recited in claim 9, wherein said coating is comprised of particles of nanomagnetic material, and wherein said particles of said nanomagnetic material are at least triatomic, being comprised of a first distinct atom, a second distinct atom, and a third distinct atom.

14. The medical device as recited in claim 13, wherein said first distinct atom is an atom selected from the group consisting of atoms of actinium, americium, berkelium, californium, cerium, chromium, cobalt, curium, dysprosium, einsteinium, erbium, europium, fermium, gadolinium, holmium, iron, lanthanum, lawrencium, lutetium, manganese, mendelevium, nickel, neodymium, neptunium, nobelium, plutonium, praseodymium, promethium, protactinium, samarium, terbium, thorium, thulium, uranium, and ytterbium, and mixtures thereof.

15. The medical device as recited in claim 14, wherein said second distinct atom is selected from the group consisting of silicon, aluminum, boron, platinum, tantalum, palladium, yttrium, zirconium, titanium, calcium, cerium, beryllium, barium, silver, gold, indium, lead, tin, antimony, germanium, gallium, tungsten, bismuth, strontium, magnesium, zinc, and mixtures thereof.

16. The medical device as recited in claim 15, wherein from about 2 to about 20 mole percent of said first distinct atom is present in said coating, by combined moles of said first distinct atom and said second distinct atom.

17. The medical device as recited in claim 15, wherein from about 17 to about 20 mole percent of said first distinct atom is present in said coating, by combined moles of said first distinct atom and said second distinct atom.

18. The medical device as recited in claim 15, wherein said first distinct atom is iron and said second distinct atom is aluminum.

4. An implantable medical device comprised of a lumen, wherein:

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device, and the concentration of said first radio frequency electromagnetic radiation that penetrates to the lumen of said device is substantially identical at different points within such lumen;

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device, and the concentration of said second radio frequency electromagnetic radiation that penetrates to the lumen of said device is substantially identical at different points within such lumen.

5. The implantable medical device as recited in claim 4, wherein said medical device has a volume of from about 1×

10<sup>−

7</sup> cubic meters to 1×

10<sup>−

5</sup> cubic meters.

6. The implantable medical device as recited in claim 4, wherein said first frequency and said second frequency differ from each other by a factor of at least about 1.5.

19. A coated medical device assembly with a volume of from about 1×

10<sup>−

7</sup> cubic meters to 1×

10<sup>−

5</sup> cubic meters. wherein said medical device assembly is comprised of a medical device, a coating disposed on said medical device, and a lumen disposed within said medical device, wherein;

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device,

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device,

(c) said first frequency and said second frequency differ from each other by a factor of at least about 1.5, at least one of such frequencies being 1.5 times as great as the other, and

(d) said coating is comprised of material with a magnetization when measured at a direct current magnetic field of 2 Testa of from about 0.2 to about 1 electromagnetic units per cubic centimeter.

20. The coated medical device assembly as recited in claim 19, wherein said medical device is a stent.

21. The coated medical device assembly as recited in claim 19, wherein said coating is comprised of material with a magnetization when measured at a direct current magnetic field of 2 Tesla of from about 0.2 to about 0.8 electromagnetic units per cubic centimeter.

22. A coated medical device assembly with a volume of from about 1×

10<sup>−

7</sup> cubic meters to 1×

10<sup>−

5</sup> cubic meters, wherein said medical device assembly is comprised of a medical device, a coating disposed on said medical device, and a lumen disposed within said medical device, wherein;

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device,

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device,

(c) said first frequency and said second frequency differ from each other by a factor of at least about 1.5, at least one of such frequencies being 1.5 times as great as the other, and

(d) said coating has a relative magnetic permeability when measured at a radio frequency of 64 megahertz of at least 1.2

23. The coated assembly as recited in claim 22, wherein said coating has a relative permeability when measured at a radio frequency of 64 megahertz of at least 1.3.

24. A coated medical device assembly with a volume of from about 1×

10<sup>−

7</sup> cubic meters to 1×

10<sup>−

5</sup> cubic meters. wherein said medical device assembly is comprised of a medical device, a coating disposed on said medical device, and a lumen disposed within said medical device, wherein;

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device,

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device,

(c) said first frequency and said second frequency differ from each other by a factor of at least about 1.5, at least one of such frequencies being 1.5 times as great as the other, and

(d) said coated medical device assembly has a magnetic susceptibility within the range of plus or minus 1×

10<sup>−

3</sup> centimeter-gram-seconds.

25. A coated medical device assembly with a relative dielectric constant of from about 1 to about 100, wherein said medical device assembly is comprised of a medical device, a coating disposed on said medical device, and a lumen disposed within said medical device, wherein:

(a) when said device is exposed to a first radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said first radio frequency electromagnetic radiation penetrates to the lumen of the device,

(b) when said device is exposed to a second radio frequency electromagnetic radiation with a frequency of from 10 megahertz to about 300 megahertz, at least 90 percent of said second radio frequency electromagnetic radiation penetrates to the lumen of the device,

(c) said first frequency and said second frequency differ from each other by a factor of at least about 1.5, at least one of such frequencies being 1.5 times as great as the other, and

(d) the product of said relative dielectric constant of said medical device and the relative magnetic permeability of such medical device is at least 50.

26. The medical device as recited in claim 25, wherein said product of said relative dielectric constant of said medical device and the relative magnetic permeability of such medical device is at least 100;

and wherein said relative magnetic permeability of such medical device is at least 1.

27. The medical device as recited in claim 26, wherein said product of said relative dielectric constant of said medical device and the relative magnetic permeability of such medical device is at least 1,000.