Use of visible light at wavelengths of 500 nm and higher to pathogen reduce blood and blood components
First Claim
1. A process for pathogen reducing a fluid which may contain pathogens having nucleic acids comprising;
- adding to the fluid a sensitizer containing a flavin moiety;
allowing the sensitizer to bind to the nucleic acid of the pathogens to make a fluid having bound sensitizer and unbound sensitizer; and
irradiating the fluid wherein only the bound sensitizer is activated.
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Abstract
This invention is directed towards a method of using visible light at wavelengths of at least 500 nm and above in combination with a sensitizer having a flavin moiety to reduce any pathogens that may be contained in blood and blood components. By exposing the blood and blood components to light of 500 nm and higher, only the sensitizer that is bound to nucleic acids of the pathogens will be activated, thus destroying the sensitizer-pathogenic nucleic acid complex. Because unbound sensitizer is not activated at this wavelength, damage to blood and blood components caused by photolysis of unbound sensitizer may be avoided.
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Citations
13 Claims
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1. A process for pathogen reducing a fluid which may contain pathogens having nucleic acids comprising;
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adding to the fluid a sensitizer containing a flavin moiety;
allowing the sensitizer to bind to the nucleic acid of the pathogens to make a fluid having bound sensitizer and unbound sensitizer; and
irradiating the fluid wherein only the bound sensitizer is activated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification