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Method to detect prostate cancer in a sample

  • US 20050282170A1
  • Filed: 02/09/2004
  • Published: 12/22/2005
  • Est. Priority Date: 02/07/2003
  • Status: Abandoned Application
First Claim
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1. A method for determining a predisposition, or presence of prostate cancer in a patient comprising:

  • a) contacting a biological sample of said patient with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide selected from the group consisting of;

    i) a polynucleotides according to SEQ ID NOs 9, 10 and 13;

    ii) a polynucleotide sequence that hybridizes under high stringency conditions to the polynucleotide sequence in i); and

    iii) a polynucleotide sequence fully complementary to i) or ii); and

    contacting said biological sample with at least one oligonucleotide that hybridizes with a second prostate specific polynucleotide, b) detecting in said biological sample an amount of PCA3 and second prostate specific polynucleotides; and

    comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and therefrom determining the presence or absence of prostate cancer in the biological sample.

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