Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
First Claim
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1. A therapeutic composition comprising a) a first active component which promotes bone formation and promotes bone resorption;
- and b) a second active component which is a GLP-2, or an analogue or derivative or mimic of GLP-2 having the ability to bind and activate a GLP-2 receptor, or is a GLP-2 receptor agonist.
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Abstract
The present invention relates to methods for prevention and treatment of bone-related disorders and calcium homeostasis related syndromes using a GLP-2 molecule or GLP-2 activator either alone or in combination with another therapeutic. The present invention also encompasses methods of diagnosing or monitoring the progression of a disorder. The invention also encompasses methods of monitoring the effectiveness of treatment of the invention.
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Citations
24 Claims
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1. A therapeutic composition comprising
a) a first active component which promotes bone formation and promotes bone resorption; - and
b) a second active component which is a GLP-2, or an analogue or derivative or mimic of GLP-2 having the ability to bind and activate a GLP-2 receptor, or is a GLP-2 receptor agonist. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of treatment of a patient having an undesirably low bone mass or an undesirably high rate of bone resorption or an undesirably low rate of bone formation, which method comprises administering to the patient a therapeutically effective amount of each of:
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a) a first active component which promotes bone formation and promotes bone resorption; and
b) a second active component which is a GLP-2, or a variant, an analogue, or derivative, or mimic of GLP-2 having the ability to bind and activate a GLP-2 receptor, or is a GLP-2 receptor agonist. - View Dependent Claims (18, 19, 20)
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- 21. A method of treating hypercalcaemia by therapy or by prophylaxis comprising administering to a patient in need thereof a therapeutically effective amount of a GLP-2, an analogue or derivative or mimic of GLP-2 having the ability to bind and activate a GLP-2 receptor, or is a GLP-2 receptor agonist.
Specification