Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
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Abstract
Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
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51 Claims
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1. A crystalline N-desmethylclozapine.
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2. A composition of matter comprising crystalline N-desmethylclozapine.
- 3. A crystalline N-desmethylclozapine substantially free of amorphous N-desmethylclozapine.
- 10. A crystalline N-desmethylclozapine Form A.
- 17. A crystalline N-desmethylclozapine Form B.
- 24. A crystalline N-desmethylclozapine Form C.
- 31. A crystalline N-desmethylclozapine Form D.
- 38. A crystalline N-desmethylclozapine Form E.
- 45. A pharmaceutical composition comprising crystalline N-desmethylclozapine and a pharmaceutically acceptable carrier, eluent, or excipient.
Specification