Dual acting SNRI-NMDA antagonists for the treatment of genitourinary disorders
First Claim
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1. A method of treating a genitourinary disorder in a subject in need of treatment, comprising administering to the subject a therapeutically effective amount of a dual acting SNRI-NMDA antagonist, such that the genitourinary disorder is treated:
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Accused Products
Abstract
Discolsed herein are compositions and methods for treatment of genitourinary disorders (e.g., urge incontinence). The compositions may generally include a dual-acting SNRI-NMDA antagonist (e.g., bicifadine and/or milnacipran). Alternatively, the compositions may generally include an SNRI and an NMDA antagonist.
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Citations
98 Claims
- 1. A method of treating a genitourinary disorder in a subject in need of treatment, comprising administering to the subject a therapeutically effective amount of a dual acting SNRI-NMDA antagonist, such that the genitourinary disorder is treated:
- 68. A method of treating a genitourinary disorder in a subject in need of treatment, comprising administering to a subject in need of treatment a therapeutically effective amount of at least one dual acting SNRI-NMDA antagonist selected from the group consisting of compounds with the following structural formulas:
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83. A method of treating overactive bladder in a subject comprising administering to the subject a therapeutically effective amount of a dual acting SNRI-NMDA antagonist, such that the overactive bladder is treated.
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84-87. -87. (canceled)
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88. A method of treating overactive bladder in a subject in need of treatment, comprising administering to said subject a therapeutically effective amount of at least one dual acting SNRI-NMDA antagonist selected from the group consisting of compounds with the following structural formulas:
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89-90. -90. (canceled)
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91. A kit for treating a genitourinary disorder in a subject in need of treatment, comprising:
a dual acting SNRI-NMDA antagonist, packaged with an instructional insert for using the dual acting SNRI-NMDA antagonist for the treatment of the genitourinary disorder.
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92-94. -94. (canceled)
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95. A kit for treating a genitourinary disorder in a subject in need of treatment, comprising:
an SNRI packaged with an instructional insert for using the SNRI together with an NMDA antagonist for the treatment of a genitourinary disorder.
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96. (canceled)
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97. A kit for treating a genitourinary disorder in a subject in need of treatment, comprising:
an NMDA antagonist packaged with an instructional insert for using the NMDA antagonist together with an SNRI for the treatment of a genitourinary disorder.
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98-107. -107. (canceled)
Specification