Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
First Claim
1. A compound of formula (I), or a pharmacologically acceptable salt, ester or other derivative thereof:
- wherein;
A represents a pyrrole ring;
R1 is selected from the group consisting of aryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group a defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below, and heteroaryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below;
R2 represents a heteroaryl group defined below having at least one ring nitrogen atom, said heteroaryl group optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below;
R3 represents a group of the formula —
X—
R4, wherein;
X is selected from the group consisting of single bonds, lower alkylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below, lower alkenylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below, and lower alkynylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below; and
R4 is selected from the group consisting of cycloalkyl groups defined below which are substituted with at least one susbtituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below, aryl groups defined below which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below, heterocyclyl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below, heterocyclyl groups defined below having at least one nitrogen atom, said heterocyclyl groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group a defined below and Substituent group δ
defined below, heteroaryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below, heteroaryl groups defined below having at least one nitrogen atom, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below, and groups of formula —
NRaRb, wherein Ra and Rb are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups defined below;
PROVIDED THAT said substituents R1 and R3 are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded;
Substituent group α
comprises hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, and halogeno lower alkylthio groups defined below;
Substituent group β
comprises groups of formula —
NRcRd, wherein Rc and Rd are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups, or Rc and Rd, together with the nitrogen atom to which Rc and Rd are bonded, form a heterocyclyl group defined below;
Substituent group γ
comprises lower alkyl groups defined below which are substituted with a group of formula —
NRcRd, wherein Rc and Rd are as defined above; and
Substituent group δ
comprises lower alkyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, lower alkenyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, lower alkynyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, aralkyl groups defined below and cycloalkyl groups defined below;
said optionally substituted aryl groups in the definitions of substituents R1 and R4 above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aromatic hydrocarbon groups optionally being fused with a cycloalkyl group having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups in the definition of substituent R1 above and said heteroaryl groups which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined above and Substituent group γ
defined above and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group a defined above and Substituent group δ
defined above in the definition of substituent R4 above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said aromatic heterocyclic groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and cycloalkyl groups having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of substituent R2 above and said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of substituent R4 above are 5- to 7-membered aromatic heterocyclic groups containing one or two nitrogen atoms and optionally containing one or two further heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms;
said lower alkylene groups in the definition of group X above are straight or branched alkylene groups having from 1 to 6 carbon atoms;
said lower alkenylene groups in the definition of group X above are straight or branched alkenylene groups having from 2 to 6 carbon atoms;
said lower alkynylene groups in the definition of group X above are straight or branched alkynylene groups having from 2 to 6 carbon atoms;
said cycloalkyl groups in the definitions of substituent R4 above and Substituent group δ
above are cycloalkyl groups having from 3 to 7 carbon atoms;
said heterocyclyl groups which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined above and Substituent group δ
defined above and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined above and Substituent group γ
defined above in the definition of substituent R4 above are non-aromatic heterocyclic groups having from 4 to 14 ring atoms in one or more rings, at least one of said ring atoms being a heteroatom selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said heterocyclyl groups having at least one ring nitrogen atom in which said heterocyclyl groups may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined above and Substituent group δ
defined above in the definition of substituent R4 above are 4- to 12-membered non-aromatic heterocyclic groups containing one nitrogen atom and optionally containing one further heteroatom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, said non-aromatic heterocyclic groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said lower alkyl groups in the definition of substituents Ra, Rb, Rc and Rd above, said lower alkyl groups which may optionally be substituted with at least one substituent selected from Substituent group a in the definition of Substituent group δ
above and said lower alkyl moiety of the lower alkyl groups substituted with a group of formula —
NRcRd in the definition of Substituent group γ
above are straight or branched alkyl groups having from 1 to 6 carbon atoms;
said lower alkenyl groups in the definition of substituents Ra, Rb, Rc and Rd above and said lower alkenyl groups which may optionally be substituted with at least one substituent selected from Substituent group a in the definition of Substituent group δ
above are straight or branched alkenyl groups having from 2 to 6 carbon atoms;
said lower alkynyl groups in the definition of substituents Ra, Rb, Rc and Rd above and said lower alkynyl groups which may optionally be substituted with at least one substituent selected from Substituent group α
in the definition of Substituent group δ
above are straight or branched alkynyl groups having from 2 to 6 carbon atoms;
said aralkyl groups in the definition of Ra, Rb, Rc and Rd above and in the definition of Substituent group δ
above are lower alkyl groups as defined above which are substituted with at least one aryl group as defined above;
said lower alkylsulfonyl groups in the definition of substituents Ra, Rb, Rc and Rd are lower alkyl groups as defined above which are bonded to a sulfonyl group;
said heterocyclyl groups formed by substituents Rc and Rd together with the nitrogen atom to which they are bonded are heterocyclyl groups having at least one nitrogen atom as defined above in relation to substituent R4 above, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said lower alkoxy groups in the definition of Substituent group α
above are lower alkyl groups as defined above which are bonded to an oxygen atom;
said halogeno lower alkoxy groups in the definition of Substituent group α
above are lower alkoxy groups as defined above which are substituted with at least one halogen atom;
said lower alkylthio groups in the definition of Substituent group α
above are lower alkyl groups as defined above which are bonded to a sulfur atom; and
said halogeno lower alkylthio groups in the definition of Substituent group α
above are lower alkylthio groups as defined above which are substituted with at least one halogen atom;
PROVIDED THAT R3 is not a group of the following formula (II);
wherein;
m represents 0 or 1;
n represents 1 or 2;
R5, R6, R7, R8 and R9 are the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
one of D and E represents a group of formula >
NR10 wherein R10 is selected from the group consisting of hydrogen atoms, Substituent group γ and
Substituent group δ
, and the other represents a group of formula >
CR11R12 wherein R11 and R12 are the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
, or R6 may form, together with R5 or R7, a single bond, and/or R10 and R11 together may form a straight or branched alkylene group having from 1 to 6 carbon atoms which is unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
when R1 is phenyl or naphthyl, and R2 is pyridyl or pyrimidinyl.
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Accused Products
Abstract
Compounds having activity against production of inflammatory cytokines of formula (I)′:
A′ is pyrrole; R1′ is aryl or heteroaryl; R2′ is heteroaryl having at least one nitrogen atom; R3′ is (IIa)′, (IIb)′ or (IIc)′:
m′ is 1 or 2; one of D′ and E′ is nitrogen and the other is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 4- to 7-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′: hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′: alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′: oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
19 Citations
196 Claims
-
1. A compound of formula (I), or a pharmacologically acceptable salt, ester or other derivative thereof:
-
wherein;
A represents a pyrrole ring;
R1 is selected from the group consisting of aryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group a defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below, andheteroaryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below;
R2 represents a heteroaryl group defined below having at least one ring nitrogen atom, said heteroaryl group optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
defined below, Substituent group β
defined below, Substituent group γ
defined below and Substituent group δ
defined below;
R3 represents a group of the formula —
X—
R4, wherein;
X is selected from the group consisting of single bonds, lower alkylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below, lower alkenylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below, and lower alkynylene groups, defined below, which may optionally be substituted with at least one substituent selected from Substituent group α
defined below; and
R4 is selected from the group consisting of cycloalkyl groups defined below which are substituted with at least one susbtituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below,aryl groups defined below which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below,heterocyclyl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below, heterocyclyl groups defined below having at least one nitrogen atom, said heterocyclyl groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group a defined below and Substituent group δ
defined below,heteroaryl groups defined below which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined below and Substituent group γ
defined below,heteroaryl groups defined below having at least one nitrogen atom, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
defined below and Substituent group δ
defined below, andgroups of formula —
NRaRb, wherein Ra and Rb are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups defined below;
PROVIDED THAT said substituents R1 and R3 are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2 is bonded;
Substituent group α
comprises hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, and halogeno lower alkylthio groups defined below;
Substituent group β
comprises groups of formula —
NRcRd, wherein Rc and Rd are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups, orRc and Rd, together with the nitrogen atom to which Rc and Rd are bonded, form a heterocyclyl group defined below;
Substituent group γ
comprises lower alkyl groups defined below which are substituted with a group of formula —
NRcRd, wherein Rc and Rd are as defined above; and
Substituent group δ
comprises lower alkyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, lower alkenyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, lower alkynyl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
defined above, aralkyl groups defined below and cycloalkyl groups defined below;
said optionally substituted aryl groups in the definitions of substituents R1 and R4 above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aromatic hydrocarbon groups optionally being fused with a cycloalkyl group having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups in the definition of substituent R1 above and said heteroaryl groups which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined above and Substituent group γ
defined above and which may optionally be further substituted with at least one substituent selected from the group consisting of Substituent group a defined above and Substituent group δ
defined above in the definition of substituent R4 above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said aromatic heterocyclic groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and cycloalkyl groups having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of substituent R2 above and said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of substituent R4 above are 5- to 7-membered aromatic heterocyclic groups containing one or two nitrogen atoms and optionally containing one or two further heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms;
said lower alkylene groups in the definition of group X above are straight or branched alkylene groups having from 1 to 6 carbon atoms;
said lower alkenylene groups in the definition of group X above are straight or branched alkenylene groups having from 2 to 6 carbon atoms;
said lower alkynylene groups in the definition of group X above are straight or branched alkynylene groups having from 2 to 6 carbon atoms;
said cycloalkyl groups in the definitions of substituent R4 above and Substituent group δ
above are cycloalkyl groups having from 3 to 7 carbon atoms;
said heterocyclyl groups which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined above and Substituent group δ
defined above and which are substituted with at least one substituent selected from the group consisting of Substituent group β
defined above and Substituent group γ
defined above in the definition of substituent R4 above are non-aromatic heterocyclic groups having from 4 to 14 ring atoms in one or more rings, at least one of said ring atoms being a heteroatom selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said heterocyclyl groups having at least one ring nitrogen atom in which said heterocyclyl groups may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
defined above and Substituent group δ
defined above in the definition of substituent R4 above are 4- to 12-membered non-aromatic heterocyclic groups containing one nitrogen atom and optionally containing one further heteroatom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, said non-aromatic heterocyclic groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said lower alkyl groups in the definition of substituents Ra, Rb, Rc and Rd above, said lower alkyl groups which may optionally be substituted with at least one substituent selected from Substituent group a in the definition of Substituent group δ
above and said lower alkyl moiety of the lower alkyl groups substituted with a group of formula —
NRcRd in the definition of Substituent group γ
above are straight or branched alkyl groups having from 1 to 6 carbon atoms;
said lower alkenyl groups in the definition of substituents Ra, Rb, Rc and Rd above and said lower alkenyl groups which may optionally be substituted with at least one substituent selected from Substituent group a in the definition of Substituent group δ
above are straight or branched alkenyl groups having from 2 to 6 carbon atoms;
said lower alkynyl groups in the definition of substituents Ra, Rb, Rc and Rd above and said lower alkynyl groups which may optionally be substituted with at least one substituent selected from Substituent group α
in the definition of Substituent group δ
above are straight or branched alkynyl groups having from 2 to 6 carbon atoms;
said aralkyl groups in the definition of Ra, Rb, Rc and Rd above and in the definition of Substituent group δ
above are lower alkyl groups as defined above which are substituted with at least one aryl group as defined above;
said lower alkylsulfonyl groups in the definition of substituents Ra, Rb, Rc and Rd are lower alkyl groups as defined above which are bonded to a sulfonyl group;
said heterocyclyl groups formed by substituents Rc and Rd together with the nitrogen atom to which they are bonded are heterocyclyl groups having at least one nitrogen atom as defined above in relation to substituent R4 above, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups as defined above and heteroaryl groups as defined above;
said lower alkoxy groups in the definition of Substituent group α
above are lower alkyl groups as defined above which are bonded to an oxygen atom;
said halogeno lower alkoxy groups in the definition of Substituent group α
above are lower alkoxy groups as defined above which are substituted with at least one halogen atom;
said lower alkylthio groups in the definition of Substituent group α
above are lower alkyl groups as defined above which are bonded to a sulfur atom; and
said halogeno lower alkylthio groups in the definition of Substituent group α
above are lower alkylthio groups as defined above which are substituted with at least one halogen atom;
PROVIDED THAT R3 is not a group of the following formula (II);
wherein;
m represents 0 or 1;
n represents 1 or 2;
R5, R6, R7, R8 and R9 are the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
one of D and E represents a group of formula >
NR10 wherein R10 is selected from the group consisting of hydrogen atoms, Substituent group γ and
Substituent group δ
, and the other represents a group of formula >
CR11R12 wherein R11 and R12 are the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
, orR6 may form, together with R5 or R7, a single bond, and/or R10 and R11 together may form a straight or branched alkylene group having from 1 to 6 carbon atoms which is unsubstituted or substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
when R1 is phenyl or naphthyl, and R2 is pyridyl or pyrimidinyl.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 90)
wherein;
m represents 0 or 1;
n represents 1 or 2;
R5, R6, R7, R8 and R9 may be the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
one of D and E represents a group of formula >
NR10 wherein R10 is selected from the group consisting of hydrogen atoms, Substituent group γ and
Substituent group δ
, and the other represents a group of formula >
CR11R12 wherein R11 and R12 are the same or different from one another and each is selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group β
, Substituent group γ and
Substituent-group δ
, orR6 may form, together with R5 or R7, a single bond, and/or R10 and R11 together may form a straight or branched alkylene group having from 1 to 6 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
17. A compound according to claim 16 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R3 is a group of formula (II) as defined in claim 16 wherein m is 1 and n is 1.
-
18. A compound according to claim 16 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R3 is a group of formula (II) as defined in claim 16 wherein E represents a group of formula >
- NR10 and D represents a group of formula >
CR11R12.
- NR10 and D represents a group of formula >
-
19. A compound according to claim 16 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R3 is a group of formula (II) as defined in claim 16 wherein one of R5 and R7 together with R6 represents a single bond and the other represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
- , Substituent group γ and
Substituent group δ
;
R8, R9 and R12 may be the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
, and R10 and R11 may be the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
, or R10 and R11 together form an alkylene group having from 1 to 6 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
- , Substituent group γ and
-
20. A compound according to claim 16 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R3 is a group of formula (II) as defined in claim 16, wherein R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
- , Substituent group β
, Substituent group γ and
Substituent group δ
.
- , Substituent group β
-
21. A compound according to claim 16 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R3 is a group of formula (II) as defined in claim 16, wherein each of R7, R8 and R9 is a hydrogen atom, and R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
- , Substituent group β
, Substituent group γ and
Substituent group δ
.
- , Substituent group β
-
22. A compound according to any one of claims 1 to 21 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein said compound of formula (I) is a compound of formula (I-1) or (I-3) below:
-
23. A compound according to claim 1 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1 is an aryl group as defined in claim 1 which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
R2 is a 5- or 6-membered aromatic heterocyclic group containing one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula —
X—
R4 wherein;
R4 is selected from the group consisting of cycloalkyl groups having from 3 to 7 carbon atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,phenyl or naphthyl groups which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
.4- to 12-membered non-aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,4- to 12-membered non-aromatic heterocyclic groups containing one nitrogen atom and optionally one further heteroatom selected from the group consisting of an oxygen atom, sulfur atom and nitrogen atom, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ
,5- or 6-membered aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may be optionally substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,5- or 6-membered aromatic heterocyclic groups containing one or two nitrogen atoms, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ
, and groups of formula —
NRaRb wherein Ra and Rb are as defined in claim 1;
andX is selected from the group consisting of single bonds, alkylene groups having from 1 to 6 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α
, alkenylene groups having from 2 to 6 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α and
alkynylene groups having from 2 to 6 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α
.
-
-
24. A compound according to claim 1 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1 is an aryl group as defined in claim 1 which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
R2 is a 5- or 6-membered aromatic heterocyclic group containing one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of Substibient group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula —
X—
R4 wherein;
R4 is selected from the group consisting of cycloalkyl groups having from 3 to 7 carbon atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,phenyl or naphthyl groups which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
, 4- to 12-membered non-aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,4- to 12-membered non-aromatic heterocyclic groups containing one nitrogen atom and optionally one further heteroatom selected from the group consisting of an oxygen atom, sulfur atom and nitrogen atom, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ
,5- or 6-membered aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may be optionally substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,5- or 6-membered aromatic heterocyclic groups containing one or two nitrogen atoms, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ
, and groups of formula —
NRaRb wherein Ra and Rb+ are as defined in claim 1;
andX is selected from the group consisting of single bonds, alkylene groups having from 1 to 4 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α
, alkenylene groups having from 2 to 4 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α and
alkynylene groups having from 2 to 4 carbon atoms which may optionally be substituted with at least one substituent selected from Substituent group α
.
-
-
25. A compound according to claim 1 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is a phenyl or naphthyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
R2 is a pyridyl or pyrimidinyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula —
X—
R4 wherein;
R4 is selected from the group consisting of cycloalkyl groups having from 3 to 7 carbon atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,phenyl or naphthyl groups which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,4- to 12-membered non-aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,4- to 12-membered non-aromatic heterocyclic groups containing one nitrogen atom and optionally one further heteroatom selected from the group consisting of an oxygen atom, sulfur atom and nitrogen atom, which may optionally be substituted with at least one substituent selected from time group consisting of Substituent group α and
Substituent group δ
,5- or 6-membered aromatic heterocyclic groups containing one or two heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, which may be optionally substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ and
which are substituted with at least one substituent selected from the group consisting of Substituent group β and
Substituent group γ
,5- or 6-membered aromatic heterocyclic groups containing one or two nitrogen atoms, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α and
Substituent group δ
, and groups of formula —
NRaRb wherein Ra and Rb are as defined in claim 1;
andX is a single bond or an alkenylene group having from 2 to 4 carbon atoms.
-
-
26. A compound according to claim 1 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is a phenyl or naphthyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
;
R2 is a pyridyl or pyrimidinyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
27. A compound according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is a phenyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
1 defined below, Substituent group β
1 defined below, Substituent group γ
1 defined below and Substituent group δ
1 defined below;
R3 is a group of said formula (II) wherein m is 1 and n is 1;
said Substituent group α
1 comprises halogen atoms, said lower alkoxy groups and said halogeno lower alkoxy groups;
said Substituent group β
1 comprises a group of formula —
NRcRd wherein one of Rc and Rd is selected from the group consisting of hydrogen atoms and said lower alkyl groups and the other is selected from the group consisting of hydrogen atoms, said lower alkyl groups and said aralkyl groups;
said Substituent group γ
1 comprises lower alkyl groups as defined in claim 1 which are substituted with a substituent selected from the group consisting of amino groups, amino groups substituted with one or two of said lower alkyl groups and amino groups substituted with said aralkyl group; and
said Substituent group δ
1 comprises said lower alkyl groups, halogeno lower alkyl groups comprising said lower alkyl groups which are substituted with at least one halogen atom, hydroxy lower alkyl groups comprising said lower alkyl groups which are substituted with at least one hydroxy group and nitro lower alkyl groups comprising said lower alkyl groups which are substituted with at least one nitro group.
-
-
28. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is a phenyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
1 defined below, Substituent group β
1 defined below, Substituent group γ
1 defined below and Substituent group δ
1 defined below;
R3 is a group of formula (II) as defined in claim 16 wherein E represents a group of formula >
NR10 and D represents a group of formula >
CR11R12;
said Substituent group α
1 comprises halogen atoms, said lower alkoxy groups and said halogeno lower alkoxy groups;
said Substituent group β
1 comprises a group of formula —
NRcRd wherein one of Rc and Rd is selected from the group consisting of hydrogen atoms and said lower alkyl groups and the other is selected from the group consisting of hydrogen atoms, said lower alkyl groups and said aralkyl groups;
said Substituent group γ
1 comprises said lower alkyl groups 1 which are substituted with a substituent selected from the group consisting of amino groups, amino groups substituted with one or two of said lower alkyl groups and amino groups substituted with said aralkyl groups; and
said Substituent group δ
1 comprises said lower alkyl groups, halogeno lower alkyl groups comprising said lower alkyl groups which are substituted with at least one halogen atom, hydroxy lower alkyl groups comprising said lower alkyl groups which are substituted with at least one hydroxy group and nitro lower alkyl groups comprising said lower alkyl groups which are substituted with at least one nitro group.
-
-
29. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is a phenyl group which may optionally be substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups comprising said lower alkyl groups which are substituted with at least one halogen atom and said halogeno lower alkoxy groups;
R3 is a group of formula (II) as defined in claim 16 wherein one of R5 and R7 together with R6 represents a single bond and the other represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
;
R8, R9 and R12 are the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
, and R10 and R11 are the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
or R10 and R11 together form an alkylene group having from 1 to 6 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
30. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R3 is a group of formula (II) as defined in claim 16 wherein R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
31. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R1 is selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R3 is a group of formula (II) as defined in claim 16 wherein each of R7, R8 and R9 is a hydrogen atom, and R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
32. A compound according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R2 is a 4-pyridyl or 4-pyrimidinyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula (II) wherein m is 1 and n is 1.
-
-
33. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R2 is a 4-pyridyl or 4-pyrimidinyl group which may optionally be substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula (II) as defined in claim 16 wherein E represents a group of formula >
NR10 and D represents a group of formula >
CR11R12.
-
-
34. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R2 is a 4-pyridyl or 4-pyrimidinyl group which may optionally be substituted at the 2-thereof with a substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
; and
R3 is a group of formula (II) as defined in claim 16 wherein one of R5 and R7 together with R6 represents a single bond and the other represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
;
R8, R9 and R12 are the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
, and R10 and R11 are the same or different from one another and each represents a substituent selected from the group consisting of hydrogen atoms, Substituent group α
, Substituent group γ and
Substituent group δ
or R10 and R11 together form an alkylene group having from 1 to 6 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
35. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R2 is a 4-pyridyl or 4-pyrimidinyl group which may optionally be substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino and α
-methylbenzylamino groups; and
R3 is a group of formula (II) as defined in claim 16 wherein R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
36. A compound of formula (I) according to claim 16 or a pharmacologically acceptable salt or ester thereof, wherein:
-
R2 is a 4-pyridyl or 4-pyrimidinyl group which may optionally be substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino and α
-methylbenzylamino groups; and
R3 is a group of formula (II) as defined in claim 16 wherein each of R7, R8 and R9 is a hydrogen atom, and R10 and R11 together form a straight chain alkylene group having 3 or 4 carbon atoms which is unsubstituted or is substituted with at least one substituent selected from the group consisting of Substituent group α
, Substituent group β
, Substituent group γ and
Substituent group δ
.
-
-
37. A compound of formula (I) according to any one of claims 23 to 36 or a pharmacologically acceptable salt or ester thereof, wherein said compound of formula (I) is a compound of formula (I-1) or (1-3) below:
-
38. A compound of formula (I) according to claim 1 selected from the following group of compounds, or a pharmacologically acceptable salt or ester thereof:
-
4-(3-aminopropyl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 4-(3-acetylaminopropyl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-(3-methylaminopropyl)-3-(pyridin-4-yl)-1H-pyrrole, [5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-3-yl]-(pyridin-4-yl)methanol, 2-(4-fluorophenyl)-4-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-1-(piperidin-4-yl)-2-(pyridin-4-yl)-1H-pyrrole, 1-(1-acetylpiperidin-4-yl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-1-[1-(2-nitroethyl)piperidin-4-yl]-2-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-1-[3-(morpholin-1-yl)propyl]-2-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-1-(piperidin-3-yl)-2-(pyridin-4-yl)-1H-pyrrole, 1-(azetidin-3-yl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrole, 4-(3-dimethylaminopropyl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-[3-(piperidin-1-yl)propyl]-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-[3-(1-methylpiperazin-4-yl)propyl]-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-(1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-2-(pyridin-4-yl)-1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4-(quinuclidin-2-en-3-yl)-1H-pyrrole, 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4-(quinuclidin-3-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-(4-hydroxypiperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-2-(pyridin-4-yl)-1-(quinuclidin-3-yl)-1H-pyrrole, 1-(4-aminocyclohexyl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-2-(2-methylaminopyrimidin-4-yl)-1-(piperidin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-(8-methyl-8-azabicyclo[3.2.1]oct-2-en-3-yl)-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-4-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3-(pyridin-4-yl)-1H-pyrrole, 4-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-pyrrole, 4-(1-ethylpiperidin-4-yl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 4-(3-dimethylamino-1-propen-1-yl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 4-(4-aminobutyl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, 1-(3-dimethylaminopropyl)-3-(4-fluorophenyl)-2-(pyridin-4-yl)-1H-pyrrole, and 2-(4-fluorophenyl)-4-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole.
-
-
39. A compound of formula (I) according to claim 1 selected from the following group of compounds, or a pharmacologically acceptable salt thereof:
-
3-(4-fluorophenyl)-1-(piperidin-4-yl)-2-(pyridin-4-yl)-1H-pyrrole, 3-(4-fluorophenyl)-1-[3-(morpholin-1-yl)propyl]-2-(pyridin-4-yl)-1H-pyrrole and 4-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole.
-
-
40. A compound according to claim 1, which is 4-(8-azabicyclo[3.2.1]oct-2-en-3-yl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole, or a pharmacologically acceptable salt thereof.
-
41. A compound according to claim 1, which is 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4-(quinuclidin-2-en-3-yl)-1H-pyrrole, or a pharmacologically acceptable salt thereof.
-
42. A compound according to claim 1, which is 2-(4-fluorophenyl)-4-(8-methyl-8-azabicyclo[3.2.1]oct-2-en-3-yl)-3-(pyridin-4-yl)-1H-pyrrole, or a pharmacologically acceptable salt thereof.
-
43. A pharmaceutical composition comprising an effective amount of a pharmacologically active compound for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of an inflammatory cytokine in a human together with a carrier therefore, wherein said pharmacologically active compound is a compound of formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof according to any one of claims 1 to 21.
-
44. A pharmaceutical composition comprising an effective amount of a pharmacologically active compound for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of an inflammatory cytokine in a human, together with a carrier therefore, wherein said pharmacologically active compound is a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to claim 22.
-
45. A pharmaceutical composition comprising an effective amount of a pharmacologically active compound for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of an inflammatory cytokine in a human, together with a carrier therefore, wherein said pharmacologically active compound is a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to any one of claims 23 to 36.
-
46. A pharmaceutical composition comprising an effective amount of a pharmacologically active compound for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of an inflammatory cytokine in a human, together with a carrier therefore, wherein said pharmacologically active compound is a compound of formula (I) or a pharmacologically acceptable salt thereof according to claim 37.
-
47. A pharmaceutical composition comprising an effective amount of a pharmacologically active compound for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of an inflammatory cytokine in a human, together with a carrier therefore, wherein said pharmacologically active compound is a compound of formula (I) or a pharmacologically acceptable salt thereof according to any one of claims 38 to 42.
-
48. A method for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of inflammatory cytokines in a human which comprises administering to a human in need thereof a pharmacologically effective amount of a compound of formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof according to any one of claims 1 to 21.
-
49. A method for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of inflammatory cytokines in a human which comprises administering to a human in need thereof a pharmacologically effective amount of a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to claim 22.
-
50. A method for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of inflammatory cytokines in a human which comprises administering to a human in need thereof a pharmacologically effective amount of a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to any one of claims 23 to 36.
-
51. A method for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of inflammatory cytokines in a human which comprises administering to a human in need thereof a pharmacologically effective amount of a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to claim 37.
-
52. A method for the treatment or prophylaxis of a disease which is treatable or preventable by inhibiting the production of inflammatory cytokines in a human which comprises administering to a human in need thereof a pharmacologically effective amount of a compound of formula (I) or a pharmacologically acceptable salt or ester thereof according to any one of claims 38 to 42.
-
53. A method according to claim 48 for inhibiting bone resorption.
-
54. A method according to claim 52 for inhibiting bone resorption.
-
55. A method according to claim 48 for the treatment or prophylaxis of an inflammatory disease.
-
56. A method according to claim 52 for the treatment or prophylaxis of an inflammatory disease.
-
57. A method according to claim 48 for the treatment or prophylaxis of a viral disease.
-
58. A method according to claim 52 for the treatment or prophylaxis of a viral disease.
-
59. A method according to claim 48 for relieving pain or pyrexia.
-
60. A method according to claim 52 for relieving pain or pyrexia.
-
61. A method according to claim 48 for the treatment or prophylaxis of chronic rheumatoid arthritis.
-
62. A method according to claim 52 for the treatment or prophylaxis of chronic rheumatoid arthritis.
-
63. A method according to claim 48 for the treatment or prophylaxis of osteoarthritis.
-
64. A method according to claim 52 for the treatment or prophylaxis of osteoarthritis.
-
65. A method according to claim 48 for the treatment or prophylaxis of cancer.
-
66. A method according to claim 52 for the treatment or prophylaxis of cancer.
-
67. A method according to claim 48 for the treatment or prophylaxis of hepatitis.
-
68. A method according to claim 52 for the treatment or prophylaxis of hepatitis.
-
69. A method according to claim 48 for the treatment or prophylaxis of a disease selected from the group consisting of an allergic disease, septicaemia, psoriasis, osteoporosis, ulcerative colitis, diabetes, nephritis, ischemic heart disease, Alzheimer'"'"'s disease and arteriosclerosis.
-
70. A method according to claim 52 for the treatment or prophylaxis of a disease selected from the group consisting of an allergic disease, septicaemia, psoriasis, osteoporosis, ulcerative colitis, diabetes, nephritis, ischemic heart disease, Alzheimer'"'"'s disease and arteriosclerosis.
-
90. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein R4′
- is a substituent selected from the group consisting of hydroxy groups, fluorine atoms, chlorine atoms, methoxy groups, ethoxy groups, propoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups which is optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
as defined in claim 69.
- is a substituent selected from the group consisting of hydroxy groups, fluorine atoms, chlorine atoms, methoxy groups, ethoxy groups, propoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups which is optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
-
71. A compound of formula (I)′
- , or a pharmacologically acceptable salt, ester or other derivative thereof;
wherein;
A′
represents a pyrrole ring;
R1′
is selected from the group consisting ofaryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below, andheteroaryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below;
R2′
represents a heteroaryl group defined below which has at least one ring nitrogen atom, said heteroaryl group optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below; and
R3′
represents a group of formula (IIa)′
, (IIb)′
or (IIc)′
shown below;
wherein m′
represents 1 or 2,one of D′ and
E′
represents a nitrogen atom and the other represents a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, Substituent group α
′
defined below and Substituent group β
′
defined below,B′
represents a 4- to 7-membered heterocyclic ring which has at least one ring nitrogen atom, said heterocyclic ring being saturated or unsaturated, and is optionally fused with a group selected from the group consisting of aryl groups defined below, heteroaryl groups defined below, cycloalkyl groups defined below and heterocyclyl groups defined below, andR4′
represents from 1 to 3 substituents which are independently selected from the group consisting of Substituent group α
′
defined below, Substituent group β
′
defined below and Substituent group γ
′
defined below, orwhen B′
is a heterocyclic ring which is fused to an aryl group, a heteroaryl group, a cycloalkyl group or a heterocyclyl group, R4′
may be a hydrogen atom;
PROVIDED THAT said substituents R1′
and R3′
are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2′
is bonded;
Substituent group α
′
is selected from the group consisting of hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, halogeno lower alkylthio groups defined below and groups of formula —
NRa′
Rb′
, wherein Ra′
and Rb′
are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups defined below, or Ra′
and Rb′
, taken together with the nitrogen atom to which they are attached, form a heterocyclyl group;
Substituent group β
′
is selected from the group consiting of lower alkyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkenyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkynyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, aralkyl groups defined below and cycloalkyl groups defined below;
Substituents group γ
′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups defined below, lower alkylene groups defined below, lower alkylenedioxy groups defined below, lower alkylsulfinyl groups defined below, lower alkylsulfonyl groups defined below, aryl groups defined below which are optionally substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above and Substituent group β
′
defined above, aryloxy groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, Substituent group β
′
defined above, lower alkylidenyl groups and aralkylidenyl groups;
said optionally substituted aryl groups in the definitions of R1′
, ring B′ and
Substituent group γ
′
above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aryl groups optionally being fused with a cycloalkyl group having from 3 to 10 carbon atoms;
said optionally subsituted heteroaryl groups in the definition of R1′
and ring B′
above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heteroaryl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and cycloalkyl groups having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of R2′
above are 5- to 7-membered aromatic heterocyclic groups containing at least one nitrogen atom and optionally containing one or two further heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms;
said lower alkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkyl moiety of said lower alkyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkyl groups having from 1 to 6 carbon atoms;
said lower alkenyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkenyl moiety of said lower alkenyl groups which are optionally substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkenyl groups having from 2 to 6 carbon atoms;
said lower alkynyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkynyl moiety of said lower alkynyl groups which are optionally substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkynyl groups having from 2 to 6 carbon atoms;
said aralkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above are lower alkyl groups as defined above which are substituted with at least one aryl group as defined above which optionally are substituted with from 1 to 3 substituents selected from the group consisting of Substituent group α
′
defined above and Substituent group β
′
defined above;
said lower alkylsulfonyl groups in the definitions of Ra′
, Rb′
and Substituent γ
′
above are lower alkyl groups as defined above which are bonded to a sulfonyl group;
where ring B′
is fused with a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain from 1 to 3 ring heteroatoms selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms;
where Ra′
and Rb′
together with the nitrogen atom to which they are attached represent a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain one nitrogen atom and which optionally contain one further heteroatom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and heteroaryl groups defined above;
said lower alkoxy groups in the definition of Substituent group α
′
above are groups in which an oxygen atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkoxy groups in the definition of Substituent group α
′
above are groups in which a lower alkoxy group as defined above is substituted with at least one halogen atom;
said lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a sulfur atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a lower alkylthio group as defined above is substituted with at least one halogen atom;
said cycloalkyl groups in the definition of Substituent group β
′ and
ring B′
above are cycloalkyl groups having from 3 to 7 carbon atoms;
said lower alkoxyimino groups in the definition of Substituent group γ
′
above are groups wherein the hydrogen atom of a hydroxyimino group is replaced by a lower alkyl group as defined above;
said lower alkylene groups in the definition of Substituent group γ
′
above are alkylene groups having from 2 to 6 carbon atoms;
said lower alkylenedioxy groups in the definition of Substituent group γ
′
above are groups wherein an alkylene moiety, which is a straight or branched chain alkylene group having from 1 to 6 carbon atoms, is subsitituted with 2 oxy groups;
said lower alkylsulfinyl groups in the definition of Substituent group γ
′
above are groups in which a lower alkyl group as defined above is bonded to a sulfinyl group;
said lower alkylidenyl groups in the definition of Substituent group γ
′
above are straight or branched alkylidenyl groups having from 1 to 6 carbon atoms;
said aralkylidenyl groups in the definition of Substituent group γ
′
above are lower alkylidenyl groups as defined above which are substituted with 1 or more aryl groups as defined above;
said optionally substituted aryloxy groups in the definition of Substituent group γ
′
above are groups in which an oxygen atom is attached to an aryl group as defined above;
PROVIDED THAT m′
is not 1 when R1′
is phenyl or naphthyl, R2′
is pyridyl or pyrimidinyl, E′
is a nitrogen atom, D′
is a group of the formula >
C(R5′
)— and
B′
is a 5-membered heterocyclic ring which has at least one ring nitrogen atom.- View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108)
- , or a pharmacologically acceptable salt, ester or other derivative thereof;
-
96. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein the compound of formula (I)′
- is represented by the formula (I-1)′
below;
- is represented by the formula (I-1)′
-
97. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinm′
is 1,D′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is 1 or 2 substituents which are selected independently from the group consisting of said Substituent group α
′
, said Substituent group β
′ and
Substituent group γ
1′
, wherein said Substituent group γ
1′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups, lower alkylene groups, lower alkylenedioxy groups, lower alkylsulfinyl groups, lower alkylsulfonyl groups and aryl groups which are optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
.
-
-
98. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
99. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group, andsaid Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
100. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, fluorine atoms, chlorine atoms, methoxy groups, ethoxy groups, propoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
.
-
-
101. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of methoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups.
-
-
102. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
103. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
104. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group, and said Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
105. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a phenyl group which is substituted optionally with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
106. A compound according to claim 71 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
107. A compound according to any one of claims 97 to 106 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein the compound of formula (I)′
- is a compound of formula (I-1)′
or (I-3)′
shown below;
- is a compound of formula (I-1)′
-
108. A compound according to any one of claims 97 to 106 or a pharmacologically acceptable salt, ester or other derivative thereof, wherein the compound of formula (I)′
- is a compound of formula (I-1)′
shown below;
- is a compound of formula (I-1)′
-
109. A pharmaceutical composition comprising a pharmacologically effective amount of a pharmacologically active compound together with a carrier therefor, wherein said pharmacologically active compound is a compound of formula (I)′
- or a pharmacologically acceptable salt, ester or other derivative thereof;
wherein;
A′
represents a pyrrole ring;
R1′
is selected from the group consisting ofaryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below, andheteroaryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below;
R2′
represents a heteroaryl group defined below which has at least one ring nitrogen atom, said heteroaryl group optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below; and
R3′
represents a group of formula (IIa)′
, (IIb)′
or (IIc)′
shown below;
wherein m′
represents 1 or 2,one of D′ and
E′
represents a nitrogen atom and the other represents a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, Substituent group α
′
defined below and Substituent group β
′
defined below,B′
represents a 4- to 7-membered heterocyclic ring which has at least one ring nitrogen atom, said heterocyclic ring being saturated or unsaturated, and optionally is fused with a group selected from the group consisting of aryl groups defined below, heteroaryl groups defined below, cycloalkyl groups defined below and heterocyclyl groups defined below, andR4′
represents from 1 to 3 substituents which are independently selected from the group consisting of Substituent group α
′
defined below, Substituent group β
′
defined below and Substituent group γ
′
defined below, orwhen B′
is a heterocyclic ring which is fused to an aryl group, a heteroaryl group, a cycloalkyl group or a heterocyclyl group, R4′
may be a hydrogen atom;
PROVIDED THAT said substituents R1′
and R3′
are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2′
is bonded;
Substituent group α
′
is selected from the group consisting of hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, halogeno lower alkylthio groups defined below and groups of formula —
NRa′
Rb′
, wherein Ra′
and Rb′
are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups defined below, or Ra′
and Rb′
, taken together with the nitrogen atom to which they are attached, form a heterocyclyl group;
Substituent group β
′
is selected from the group consisting of lower alkyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkenyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkynyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, aralkyl groups defined below and cycloalkyl groups defined below;
Substituents group γ
′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups defined below, lower alkylene groups defined below, lower alkylenedioxy groups defined below, lower alkylsulfinyl groups defined below, lower alkylsulfonyl groups defined below, aryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above and Substituent group β
′
defined above, aryloxy groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, Substituent group β
′
defined above, lower alkylidenyl groups and aralkylidenyl groups;
said optionally substituted aryl groups in the definitions of R1′
, ring B′ and
Substituent group γ
′
above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aryl groups optionally being fused with a cycloalkyl group having from 3 to 10 carbon atoms;
said optionally subsituted heteroaryl groups in the definition of R1′
and ring B′
above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heteroaryl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and cycloalkyl groups having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of R2′
above are 5- to 7-membered aromatic heterocyclic groups containing at least one nitrogen atom and optionally containing one or two further heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms;
said lower alkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkyl moiety of said lower alkyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkyl groups having from 1 to 6 carbon atoms;
said lower alkenyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkenyl moiety of said lower alkenyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkenyl groups having from 2 to 6 carbon atoms;
said lower alkynyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkynyl moiety of said lower alkynyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkynyl groups having from 2 to 6 carbon atoms;
said aralkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above are lower alkyl groups as defined above which are substituted with at least one aryl group as defined above which optionally are substituted with from 1 to 3 substituents selected from the group consisting of Substituent group α
′
defined above and Substituent group β
′
defined above;
said lower alkylsulfonyl groups in the definitions of Ra′
, Rb′
and Substituent γ
′
above are lower alkyl groups as defined above which are bonded to a sulfonyl group;
where ring B′
is fused with a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain from 1 to 3 ring heteroatoms selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms;
where Ra′
and Rb′
together with the nitrogen atom to which they are attached represent a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain one nitrogen atom and which optionally contain one further heteroatom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and heteroaryl groups defined above;
said lower alkoxy groups in the definition of Substituent group α
′
above are groups in which an oxygen atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkoxy groups in the definition of Substituent group α
′
above are groups in which a lower alkoxy group as defined above is substituted with at least one halogen atom;
said lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a sulfur atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a lower alkylthio group as defined above is substituted with at least one halogen atom;
said cycloalkyl groups in the definition of Substituent group β
′ and
ring B′
above are cycloalkyl groups having from 3 to 7 carbon atoms;
said lower alkoxyimino groups in the definition of Substituent group γ
′
above are groups wherein the hydrogen atom of a hydroxyimino group is replaced by a lower alkyl group as defined above;
said lower alkylene groups in the definition of Substituent group γ
′
above are alkylene groups having from 2 to 6 carbon atoms;
said lower alkylenedioxy groups in the definition of Substituent group γ
′
above are groups wherein an alkylene moiety, which is a straight or branched chain alkylene group having from 1 to 6 carbon atoms, is subsitituted with 2 oxy groups;
said lower alkylsulfinyl groups in the definition of Substituent group γ
′
above are groups in which a lower alkyl group as defined above is bonded to a sulfinyl group;
said lower alkylidenyl groups in the definition of Substituent group γ
′
above are straight or branched alkylidenyl groups having from 1 to 6 carbon atoms;
said aralkylidenyl groups in the definition of Substituent group γ
′
above are lower alkylidenyl groups as defined above which are substituted with 1 or more aryl groups as defined above;
said optionally substituted aryloxy groups in the definition of Substituent group γ
′
above are groups in which an oxygen atom is attached to an aryl group as defined above,PROVIDED that m′
is not 1 when R1′
is phenyl or naphthyl, R2′
is pyridyl or pyrimidinyl, E′
is a nitrogen atom, D′
is a group of the formula >
C(R5′
)— and
B′
is a 5-membered heterocyclic ring which has at least one ring nitrogen atom.- View Dependent Claims (110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146)
- or a pharmacologically acceptable salt, ester or other derivative thereof;
-
134. A pharmaceutical composition according to claim 109, wherein the compound of formula (I)′
- is represented by the formula (I-1)′
below;
- is represented by the formula (I-1)′
-
135. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinm′
is 1,D′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′ and
E′
is a nitrogen atom, andR4′
is 1 or 2 substituents which are independently selected from the group consisting of said Substituent group α
′
, said Substituent group β
′ and
Substituent group γ
1′
, wherein said Substituent group γ
1′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups, lower alkylene groups, lower alkylenedioxy groups, lower alkylsulfinyl groups, lower alkylsulfonyl groups and aryl groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
.
-
-
136. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
137. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group, andsaid Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
138. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, fluorine atoms, chlorine atoms, methoxy groups, ethoxy groups, propoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
.
-
-
139. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of methoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups.
-
-
140. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
141. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
142. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group, andsaid Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
143. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
144. A pharmaceutical composition according to claim 109, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2 is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
-whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
145. A pharmaceutical composition according to any one of claims 135 to 144 wherein the compound of formula (I)′
- is a compound of formula (I-1)′
or (I-3)′
shown below;
- is a compound of formula (I-1)′
-
146. A pharmaceutical composition according to any one of claims 135 to 144 wherein the compound of formula (I)′
- is a compound of formula (I-1)′
;
- is a compound of formula (I-1)′
-
147. A method for the treatment or prophylaxis of a disease treatable or preventable by inhibiting the production of inflammatory cytokines in a mammal which comprises administering to said mammal a pharmacologically effective amount of a compound of formula (I)′
- or a pharmacologically acceptable salt, ester or other derivative thereof;
wherein;
A′
represents a pyrrole ring;
R1′
is selected from the group consisting ofaryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined below and Substituent group β
′
defined below, andheteroaryl groups defined below which may optionally be substituted with at least one substituent selected from Substituent group α
′
defined below and Substituent group β
′
defined below;
R2′
represents a heteroaryl group defined below which has at least one ring nitrogen atom, said heteroaryl group optionally being substituted with at least one substituent selected from Substituent group α
′
defined below and Substituent group β
′
defined below; and
R3′
represents a group of formula (IIa)′
, (IIb)′
or (IIc)′
shown below;
wherein m′
represents 1 or 2,one of D′ and
E′
represents a nitrogen atom and the other represents a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, Substituent group α
′
defined below and Substituent group β
′
defined below,B′
represents a 4- to 7-membered heterocyclic ring which has at least one ring nitrogen atom, said heterocyclic ring being saturated or unsaturated, and optionally being fused with a group selected from the group consisting of aryl groups defined below, heteroaryl groups defined below, cycloalkyl groups defined below and heterocyclyl groups defined below, andR4′
represents from 1 to 3 substituents which are independently selected from the group consisting of Substituent group α
′
defined below, Substituent group β
′
defined below and Substituent group γ
′
defined below, orwhen B′
is a heterocyclic ring which is fused to an aryl group, a heteroaryl group, a cycloalkyl group or a heterocyclyl group, R4′
may be a hydrogen atom;
PROVIDED THAT said substituents R1′
and R3′
are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R2′
is bonded;
Substituent group α
′
is selected from the group consisting of hydroxyl groups, nitro groups, cyano groups, halogen atoms, lower alkoxy groups defined below, halogeno lower alkoxy groups defined below, lower alkylthio groups defined below, halogeno lower alkylthio groups defined below and groups of formula —
NRa′
Rb′
, wherein Ra′
and Rb′
are the same or different from each other and each is independently selected from the group consisting of hydrogen atoms, lower alkyl groups defined below, lower alkenyl groups defined below, lower alkynyl groups defined below, aralkyl groups defined below and lower alkylsulfonyl groups defined below, or Ra′
and Rb′
, taken together with the nitrogen atom to which they are attached, form a heterocyclyl group;
Substituent group β
′
is selected from the group consisting of lower alkyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkenyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, lower alkynyl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, aralkyl groups defined below and cycloalkyl groups defined below;
Substituents group γ
′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups defined below, lower alkylene groups defined below, lower alkylenedioxy groups defined below, lower alkylsulfinyl groups defined below, lower alkylsulfonyl groups defined below, aryl groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, Substituent group β
′
defined above, aryloxy groups defined below which optionally are substituted with at least one substituent selected from the group consisting of Substituent group α
′
defined above, Substituent group β
′
defined above, lower alkylidenyl groups and aralkylidenyl groups;
said optionally substituted aryl groups in the definitions of R1′
, ring B′ and
Substituent group γ
′
above are aromatic hydrocarbon groups having from 6 to 14 carbon atoms in one or more rings, said aryl groups optionally being fused with a cycloalkyl group having from 3 to 10 carbon atoms;
said optionally subsituted heteroaryl groups in the definition of R1′
and ring B′
above are 5- to 7-membered aromatic heterocyclic groups containing from 1 to 3 heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms, said heteroaryl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and cycloalkyl groups having from 3 to 10 carbon atoms;
said optionally substituted heteroaryl groups having at least one ring nitrogen atom in the definition of R2′
above are 5- to 7-membered aromatic heterocyclic groups containing at least one nitrogen atom and optionally containing one or two further heteroatoms selected from the group consisting of sulfur atoms, oxygen atoms and nitrogen atoms;
said lower alkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkyl moiety of said lower alkyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkyl groups having from 1 to 6 carbon atoms;
said lower alkenyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkenyl moiety of said lower alkenyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkenyl groups having from 2 to 6 carbon atoms;
said lower alkynyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above, and the lower alkynyl moiety of said lower alkynyl groups which optionally are substituted with at least one substituent selected from Substituent group α
′
in the definition of Substituent group β
′
above are straight or branched alkynyl groups having from 2 to 6 carbon atoms;
said aralkyl groups in the definitions of Ra′
, Rb′
and Substituent group β
′
above are lower alkyl groups as defined above which are substituted with at least one aryl group as defined above which optionally are substituted with from 1 to 3 substituents selected from the group consisting of Substituent group α
′
defined above and Substituent group β
′
defined above;
said lower alkylsulfonyl groups in the definitions of Ra′
, Rb′
and Substituent γ
′
above are lower alkyl groups as defined above which are bonded to a sulfonyl group;
where ring B′
is fused with a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain from 1 to 3 ring heteroatoms selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms;
where Ra′
and Rb′
together with the nitrogen atom to which they are attached represent a heterocyclyl group, said heterocyclyl groups are 4- to 7-membered heterocyclyl groups which contain one nitrogen atom and which optionally contain one further heteroatom selected from the group consisting of oxygen atoms, sulfur atoms and nitrogen atoms, said heterocyclyl groups optionally being fused with another cyclic group selected from the group consisting of aryl groups defined above and heteroaryl groups defined above;
said lower alkoxy groups in the definition of Substituent group α
′
above are groups in which an oxygen atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkoxy groups in the definition of Substituent group α
′
above are groups in which a lower alkoxy group as defined above is substituted with at least one halogen atom;
said lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a sulfur atom is bonded to a lower alkyl group as defined above;
said halogeno lower alkylthio groups in the definition of Substituent group α
′
above are groups in which a lower alkylthio group as defined above is substituted with at least one halogen atom;
said cycloalkyl groups in the definition of Substituent group β
′ and
ring B′
above are cycloalkyl groups having from 3 to 7 carbon atoms;
said lower alkoxyimino groups in the definition of Substituent group γ
′
above are groups wherein the hydrogen atom of a hydroxyimino group is replaced by a lower alkyl group as defined above;
said lower alkylene groups in the definition of Substituent group γ
′
above are alkylene groups having from 2 to 6 carbon atoms;
said lower alkylenedioxy groups in the definition of Substituent group γ
′
above are groups wherein an alkylene moiety, which is a straight or branched chain alkylene group having from 1 to 6 carbon atoms, is subsitituted with 2 oxy groups;
said lower alkylsulfinyl groups in the definition of Substituent group γ
′
above are groups in which a lower alkyl group as defined above is bonded to a sulfinyl group;
said lower alkylidenyl groups in the definition of Substituent group γ
′
above are straight or branched alkylidenyl groups having from 1 to 6 carbon atoms;
said aralkylidenyl groups in the definition of Substituent group γ
′
above are lower alkylidenyl groups as defined above which are substituted with 1 or more aryl groups as defined above;
said optionally substituted aryloxy groups in the definition of Substituent group γ
′
above are groups in which an oxygen atom is attached to an aryl group as defined above,PROVIDED THAT m′
is not 1 when R1′
is phenyl or naphthyl, R2′
is pyridyl or pyrimidinyl, E′
is a nitrogen atom, D′
is a group of the formula >
C(R5′
)— and
B′
is a 5-membered heterocyclic ring which has at least one ring nitrogen atom.- View Dependent Claims (148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196)
- or a pharmacologically acceptable salt, ester or other derivative thereof;
-
173. A method according to claim 148, wherein the compound of formula (I)′
- is represented by the formula (I-1)′
below;
- is represented by the formula (I-1)′
-
174. A method according to claim 148, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinm′
is 1,D′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is 1 or 2 substituents which are independently selected from the group consisting of said Substituent group α
′
, said Substituent group β
′ and
Substituent group γ
1′
, wherein said Substituent group γ
1′
is selected from the group consisting of oxo groups, hydroxyimino groups, lower alkoxyimino groups, lower alkylene groups, lower alkylenedioxy groups, lower alkylsulfinyl groups, lower alkylsulfonyl groups and aryl groups which optionally are substituted with at least one substituent selected from Substituent group α
′ and
said Substituent group β
′
.
-
-
175. A method according to claim 148, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
176. A method according to claim 148, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group andsaid Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, halogen atoms, lower alkoxy groups, lower alkylthio groups, halogeno lower alkoxy groups, lower alkyl groups, halogeno lower alkyl groups, oxo groups, aryl groups optionally substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, lower alkylenedioxy groups, lower alkylene groups and lower alkylsulfonyl groups.
-
-
177. A method according to claim 148, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
—R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of hydroxy groups, fluorine atoms, chlorine atoms, methoxy groups, ethoxy groups, propoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
.
-
-
178. A method according to claim 148, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of methoxy groups, methyl groups, ethyl groups, propyl groups and phenyl groups.
-
-
179. A method according to claim 148, wherein:
-
R1′
is an aryl group which optionally is substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a 5- or 6-membered aromatic heterocyclic group which has one or two nitrogen atoms, said group optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
180. A method according to claim 148, wherein:
-
R1′
is a phenyl or naphthyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
;
R2′
is a pyridyl or pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of Substituent group α
′ and
Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′
, said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
181. A method according to claim 148, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from Substituent group α
1′
defined below and Substituent group β
1′
defined below,said Substituent group α
1′
is selected from the group consisting of halogen atoms, lower alkoxy groups, halogeno lower alkoxy groups and groups of formula —
NRa′
Rb′
, wherein one of Ra′
and Rb′
represents a hydrogen atom or a lower alkyl group, and the other represents a hydrogen atom, a lower alkyl group or an aralkyl group,said Substituent group β
1′
is selected from the group consisting of lower alkyl groups, halogeno lower alkyl groups, hydroxyl lower alkyl groups, nitro lower alkyl groups, amino lower alkyl groups, lower alkylamino lower alkyl groups, di(lower alkyl)amino lower alkyl groups and aralkylamino lower alkyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
or formula (IIb)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of aryloxy groups which optionally are substituted with at least one substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
, alkylidene groups and aralkylidene groups.
-
-
182. A method according to claim 148, wherein:
-
R1′
is a phenyl group which optionally is substituted with at least one substituent selected from the group consisting of halogen atoms, halogeno lower alkyl groups and halogeno lower alkoxy groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of said Substituent group α
′ and
said Substituent group β
′
; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
183. A method according to claim 148, wherein:
-
R1′
is a substituent selected from the group consisting of phenyl, 4-fluorophenyl, 3-fluorophenyl, 3-chlorophenyl, 3,4-difluorophenyl, 3,4,5-trifluorophenyl, 3-chloro-4-fluorophenyl, 3-difluoromethoxyphenyl and 3-trifluoromethylphenyl groups;
R2′
is a 4-pyridyl or 4-pyrimidinyl group, said groups optionally being substituted at the 2-position thereof with a substituent selected from the group consisting of methoxy, amino, methylamino, benzylamino, and α
-methylbenzylamino groups; and
R3′
is a group of formula (IIa)′
whereinD′
is a group of formula >
C(R5′
)—
, wherein R5′
is selected from the group consisting of hydrogen atoms, said Substituent group α
′ and
said Substituent group β
′
, and E′
is a nitrogen atom, andR4′
is a substituent selected from the group consisting of phenoxy, methylidene, ethylidene, propylidene and benzylidene groups.
-
-
184. A method according to any one of claims 174 to 183, wherein the compound of formula (I)′
- is a compound of formula (I-1)′
or (I-3)′
shown below;
- is a compound of formula (I-1)′
-
185. A method according to any one of claims 174 to 183, wherein the compound of formula (I)′
- s a compound of formula (I-1)′
shown below;
- s a compound of formula (I-1)′
-
186. A method according to any one of claims 147 to 183, wherein the method is for inhibiting bone resporption, relieving inflammation, treating or preventing a viral disease, relieving pain or pyrexia, treating or preventing chronic rheumatoid arthritis, treating or preventing osteoarthritis, treating or preventing cancer or treating or preventing hepatitis.
-
187. A method according to claim 148, wherein said method is for inhibiting bone resorption.
-
188. A method according to claim 148, wherein said method is for relieving inflammation.
-
189. A method according to claim 148, wherein said method is for the treatment or prophylaxis of a viral disease.
-
190. A method according to claim 148, wherein said method is for relieving pain or pyrexia.
-
191. A method according to claim 148, wherein said method is for the treatment or prophylaxis of chronic rheumatoid arthritis.
-
192. A method according to claim 148, wherein said method is for the treatment or prophylaxis of osteoarthritis.
-
193. A method according to claim 148, wherein said method is for the treatment or prophylaxis of cancer.
-
194. A method according to claim 148, wherein said method is for the treatment or prophylaxis of hepatitis.
-
195. A method according to claim 148, wherein said method is for the treatment or prophylaxis of asthma.
-
196. A method according to any one of claims 147 to 183, wherein said method is for the treatment or prophylaxis of a disease selected from the group consisting of an allergic disease, septicaemia, psoriasis, degenerative arthritis, Crohn'"'"'s disease, systemic lupus erythematosus, osteoporosis, ulcerative colitis, diabetes, nephritis, ischemic heart disease, Alzheimer'"'"'s disease and arteriosclerosis.
Specification