Blood flow diverters for the treatment of intracranial aneurysms

• US 20050283220A1
• Filed: 06/22/2004
• Published: 12/22/2005
• Est. Priority Date: 06/22/2004
• Status: Abandoned Application

• Current Assignee: Ajay K. Wakhloo, Riad H. Gobran, Yusuf M. Khan
• Original Assignee: Ajay K. Wakhloo, Riad H. Gobran, Yusuf M. Khan
• Inventors: Khan, Yusuf M., Gobran, Riad H., Wakhloo, Ajay K.
• Application Number:
  US10/874,639
• Publication Number:
  US 20050283220A1
• Time in Patent Office: Days
• US Class Current: 623/1.4
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 29/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: D04C 1/02 made from particular materials
• CPC Class Codes: D10B 2401/046 Shape recovering or form memory
• CPC Class Codes: D10B 2403/02411 with a single array of unbent yarn, e.g. unidirectional reinforcement fabrics
• CPC Class Codes: D10B 2509/06 Vascular grafts; stents

Abstract

A blood flow diverter device for treatment of intracranial aneurysms, including a porous tubular member having a central portion and two ends. The member is of sufficient flexibility and body compatibility to be placed in proximity within an intracranial aneurysm. The central portion of the tubular member has a sufficiently decreased porosity to block blood flow from entering through the aneurysm. This is done by one of three methods: (1) the central portion of the member can be compressed to decrease porosity and heat set to hold the compression; (2) the angle of the fibers can be altered if the tubular member is made from a braided fibers; or (3) a monomeric coating can be formed on the central portion in an amount sufficient to decrease the porosity of the central portion upon polymerization of the monomeric coating. In the third embodiment a polymerization initiator is provided for polymerizing the monomeric coating upon command to cause the decreased porosity to block the blood flow. The device is heat set after compression to permit insertion and expansion in the patient. The tubular member has sufficient porosity at the two ends to keep open small perforator arteries proximate to the intracranial aneurysm.

Claims

1. (canceled)

2. The device of claim 1, wherein said two ends of said tubular member has sufficient porosity to keep open small perforator arteries proximate said intracranial aneurysm.

3. (canceled)

10. (canceled)

11. (canceled)

12. (canceled)

14. (canceled)

16. (canceled)

22. (canceled)

23. (canceled)

24. (canceled)

26. A blood flow diverter device for treatment of intracranial aneurysms, comprising:

a porous tubular member formed from braided thermoplastic fibers having a central portion and two ends, said member being of sufficient flexibility and body compatibility to be placed in proximity with an aneurysm;

said braided fibers being compressed to decrease the porosity of said central portion and heat set to preserve said decrease; and

said central portion of said tubular member having further decreased porosity by coating said central portion with a monomeric coating in an amount sufficient to decrease the porosity of said central portion upon polymerization of said monomeric coating; and

including a polymerization initiator for polymerizing said monomeric coating upon command to cause said decreased porosity to block said blood flow after said device has been placed in proximity with an aneurysm;

whereby said central portion has reduced porosity to block blood flow from entering through the aneurysm.

4. The device of claim 26, wherein said monomers contain reactive double bonds capable of undergoing polymerization triggered by an ultraviolet or infrared source.

5. The device of claim 26, wherein said monomer is selected from the group consisting of acrylate or methacrylate monomers with pendant hydrophilic groups such as acrylic or methacrylic acid and their salts;

hyroxyalkyl acrylate or methacrylate; and

ethoxyalkyl acrylate or methacrylate;

acrylamide and derivatives;

vinyl pyrollidone and derivatives;

vinyl pyridine and derivatives;

styrene sulfonate and vinyl monomers containing quaternary ammonium salts; and

mixtures thereof.

6. The device of claim 26, which further includes at least one hydrophobic monomer in an amount sufficient to limit the degree of swelling of said monomeric coating after polymerization of said monomeric coating.

7. The device of claim 6, wherein said hydrophobic monomer is selected from the group consisting of such as styrene, alkyl acrylate or methacrylate, phenylethyl acrylate or methacrylate and mixtures thereon.

8. The device of claim 26, wherein said monomeric coating further includes a cross-linking monomer for controlling swelling and preventing the resulting polymer from dissolving, said cross-linking monomer having two or more active double bonds per molecule.

9. The device of claim 8, wherein said cross-linking monomers is selected from the group consisting of divinyl benzene;

allyl acrylate or methacrylate;

di- or tri-acrylates or methacrylates;

di- or tri-alkoxyacrylates or alkoxymethacrylates and mixtures thereon.

13. The device of claim 26, which further includes a metallic fiber positioned to give radio opacity to said blood flow diverter.

28. The device of claim 26, wherein braided fibers are braided at an angle with respect to the axis of said tubular member in said central portion to decrease the porosity of said central portion, and then compressed and heat set to form an expandable device upon insertion into the body.

27. A method for treatment of intracranial aneurysms, comprising the steps of:

forming a porous tubular member from braided thermoplastic fibers having a central portion and two ends, said member being of sufficient flexibility and body compatibility to be placed in proximity with an aneurysm;

compressing said braided fibers to decrease the porosity of said central portion and heat setting said fibers to preserve said decrease;

further decreasing the porosity of said central portion of said tubular member by coating said central portion with a monomeric coating in an amount sufficient to decrease the porosity of said central portion upon polymerization of said monomeric coating; and

including a polymerization initiator for polymerizing said monomeric coating upon command to cause said decreased porosity to block said blood flow after said device has been placed in proximity with an aneurysm; and

placing said blood flow diverter device at said aneurysm and initiating said polymerizatioin of said monomeric coating to block blood flow from entering through said aneurysm.

15. The method of claim 27, wherein said tubular member is formed with two ends to have sufficient porosity to keep open small perforator arteries proximate said intracranil aneurysm.

17. The method of claim 27, wherein said monomers contain reactive double bonds capable of undergoing polymerization triggered by an ultraviolet or infrared source.

18. The method of claim 27, wherein said monomers is selected from the group consisting of acrylate or methacrylate monomers with pendant hydrophilic groups such as acrylic or methacrylic acid and their salts;

hyroxyalkyl acrylate or methacrylate; and

ethoxyalkyl acrylate or methacrylate;

acrylamide and derivatives;

vinyl pyrollidone and derivatives;

vinyl pyridine and derivatives;

styrene sulfonate and vinyl monomers containing quaternary ammonium salts; and

mixtures thereof.

19. The method of claim 27, which further includes the addition to said monomer of at least one hydrophobic monomer in an amount sufficient to limit the degree of swelling of said monomeric coating after polymerization of said monomeric coating.

20. The method of claim 19, wherein said hydrophobic monomer is selected from the group consisting of such as styrene, alkyI acrylate or methacrylate, phenylethyl acrylate or methacrylate and mixtures thereon.

21. The method of claim 27, wherein said monomeric coating further includes a cross-linking monomer for controlling swelling and preventing the resulting polymer from dissolving, said cross-linking monomer having two or more active double bonds per molecule, said cross-linking monomer being selected from the group consisting of divinyl benzene;

allyl acrylate or methacrylate;

di- or tri-acrylates or methacrylates;

di-or tri-alkoxyacrylates or alkoxymethacrylates and mixtures thereon.

25. The method of claim 27, which further includes a metallic fiber positioned to give radio opacity to said blood flow diverter.

29. The method of claim 27, wherein braided fibers are braided at a more acute angle with respect to the axis of said tubular member in said central portion to decrease the porosity of said central portion and then compressed and heat set to form an expandable device upon insertion into the body.