Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject
First Claim
1. A system for detecting in vivo pharmacokinetic, pharmacodynamic and/or metabolic activity, comprising:
- at least one radiation sensor configured to detect in vivo beta radiation at least intermittently over a period of time, the at least one sensor adapted to be positioned in solid tissue, and configured to detect the beta radiation as it is emitted in response to an administered analyte as the analyte is biochemically processed by the body, wherein the analyte comprises at least one of the following;
radiolabeled glucose, a radiolabeled glucose constituent, and a radiolabeled glucose derivative; and
a processor operably associated with the at least one radiation sensor and configured to receive data associated with the detected radiation from the at least one sensor, wherein said processor is configured to electronically monitor selected in vivo parameters associated with one or more of the uptake, processing, and retention of at least one of the radiolabeled glucose, the radio labeled glucose constituent and the radiolabeled glucose derivative in the targeted localized solid tissue based on the data received from the at least one sensor.
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Accused Products
Abstract
System for analyzing an in vivo response of a subject include a radiation detector for detecting radiation present in at least one localized solid tissue region of interest in a subject associated with internal activity of an administered quantity of an analyte comprising at least one of C-14 labeled glucose, a C-14 labeled constituent thereof, and a C-14 labeled glucose derivative, in the at least one solid tissue region of interest over a desired time interval of interest; and a reader in communication with the implantable detector for collecting radiation data from the detector associated with the detected radiation to determine at least one of the following; the in vivo dynamic, kinetic, and metabolic response of the subject.
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Citations
30 Claims
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1. A system for detecting in vivo pharmacokinetic, pharmacodynamic and/or metabolic activity, comprising:
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at least one radiation sensor configured to detect in vivo beta radiation at least intermittently over a period of time, the at least one sensor adapted to be positioned in solid tissue, and configured to detect the beta radiation as it is emitted in response to an administered analyte as the analyte is biochemically processed by the body, wherein the analyte comprises at least one of the following;
radiolabeled glucose, a radiolabeled glucose constituent, and a radiolabeled glucose derivative; and
a processor operably associated with the at least one radiation sensor and configured to receive data associated with the detected radiation from the at least one sensor, wherein said processor is configured to electronically monitor selected in vivo parameters associated with one or more of the uptake, processing, and retention of at least one of the radiolabeled glucose, the radio labeled glucose constituent and the radiolabeled glucose derivative in the targeted localized solid tissue based on the data received from the at least one sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for analyzing an in vivo response of a subject, comprising:
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an implantable radiation detector for detecting radiation present in at least one localized solid tissue region of interest in a subject associated with internal activity of an administered quantity of an analyte comprising at least one of C-14 labeled glucose, a C-14 labeled glucose constituent, and a C-14 labeled glucose derivative, in the at least one solid tissue region of interest over a desired time interval of interest; and
a reader in communication with the implantable detector for collecting radiation data from the detector associated with the detected radiation to determine at least one of the following;
the in vivo dynamic, kinetic, and metabolic response of the subject. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A system for analyzing an in vivo response of a subject, comprising:
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a radiation detector for detecting in vivo radiation present in at least one localized solid tissue region of interest in a subject associated with internal activity of an administered quantity of C-14 labeled 2-deoxyglucose in the at least one solid tissue region of interest over a desired time interval of interest; and
a reader in communication with the implantable detector for collecting radiation data from the detector associated with the detected radiation to determine at least one of the following;
the in vivo dynamic, kinetic, and metabolic response of the subject. - View Dependent Claims (23, 24)
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25. A system for analyzing an in vivo response of a subject, comprising:
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a radiation detector for detecting in vivo radiation present in at least one localized solid tissue region of interest in a subject associated with internal activity of an administered quantity of a C-14 labeled glucose derivative in the at least one solid tissue region of interest over a desired time interval of interest, wherein the glucose derivative is selected so that it has a modified glucose molecular chemical structure that is biocompatible and can be bio-chemically processed by the body; and
a reader in communication with the implantable detector for receiving and analyzing radiation data from the detector associated with at least one of the C-14 labeled glucose derivative and a C-14 labeled biochemical constituent thereof to determine at least one of the following;
the in vivo dynamic, kinetic, and metabolic response of the subject. - View Dependent Claims (26, 27, 28, 29)
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30. A system for analyzing in vivo metabolic activity of a subject undergoing treatment for cancer, comprising:
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detection means for detecting metabolic activity in vivo based on levels of radiation present in localized tissue in the subject over a time interval of interest in response to administration of a radiolabled glucose or glucose derivative; and
analyzing means for electronically analyzing the detected radiation data to determine the in vivo metabolic kinetic activity of the subject.
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Specification