Cosmetic or dermatological preparation comprising a nutrient medium phase

• US 20050287182A1
• Filed: 03/01/2005
• Published: 12/29/2005
• Est. Priority Date: 05/24/2003
• Status: Active Grant

• Current Assignee: La Prairie Group AG
• Original Assignee: Beiersdorf AG (Maxingvest AG)
• Inventors: Monks, Monika, Gohla, Sven, Evangelisti, Carmen, Ibanez, Sybille
• Granted Patent: US 8,518,422 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61F 2013/00748 with hydrocolloids or superabsorbers wound bandages with alginate A61F2013/00229; plasters with cyano-acrylic adhesive A61F2013/00459; plasters for treating burn with hydrogel A61F2013/00523; adhesive for plasters, with hydrogel A61F2013/00676; water-based A61F2013/00689; for use on mucosae A61F2013/00714; for use on wounds A61F2013/00719; with absorbent adhesives A61F2013/00757; with fumed silica A61F2013/00787; with viscoelastic oil-elastomer gel A61F2013/00893
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A cosmetic or dermatological preparation that is obtainable by combining collagen and/or a derivative thereof, chitosan and/or a derivative thereof and glycosylaminoglycan and/or a derivative thereof with one or more selected substances. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Claims

1. A cosmetic or dermatological preparation which is obtainable by combining substances comprising

(a) at least one of collagen and a derivative thereof;

(b) at least one of chitosan and an acetyl derivative thereof with a degree of acetylation of up to about 50%;

(c) at least one of a glycosylaminoglycan and a derivative thereof; and

(d) at last one substance selected from amino acids, α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, folic acid, glucose, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, and ZnSO₄.

2. The preparation of claim 1, wherein the amino acids comprise one or more of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-cysteine, L-cystine, glycine, L-glutamine, L-glutamic acid, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine and the hydrochloride salts thereof.

3. The preparation of claim 2, wherein at least two substances from group (d) are employed.

4. The preparation of claim 3, wherein at least five substances from group (d) are employed.

5. The preparation of claim 4, wherein at least ten substances from group (d) are employed.

6. The preparation of claim 5, wherein at least fifty substances from group (d) are employed.

7. The preparation of claim 1, wherein one or more of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and L-glycine are employed.

8. The preparation of claim 7, wherein at least three of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and glycine are employed.

9. The preparation of claim 8, wherein at least five of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and glycine are employed.

10. The preparation of claim 1, wherein glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and glycine are employed.

11. The preparation of claim 1, wherein at least one of substances (a) and (b) is of marine origin or of synthetic origin.

12. The preparation of claim 1, wherein the collagen comprises one or more collagens selected from types 1, 3, 4 and 5.

13. The preparation of claim 1, wherein the chitosan comprises chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol.

14. The preparation of claim 13, wherein the chitosan comprises chitosan obtained from at least one of crustaceans and insects.

15. The preparation of claim 12, wherein the glycosylaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

16. The preparation of claim 2, wherein substances (a) to (c) are employed in a total amount of from about 0.0005% to about 50% by weight, based on a total weight of the preparation.

17. The preparation of claim 16, wherein the total amount of substances (a) to (c) is from about 0.0015% to about 30% by weight.

18. The preparation of claim 7, wherein substances (a) to (c) are employed in a total amount of from about 0.005% to about 10% by weight, based on a total weight of the preparation.

19. The preparation of claim 8, wherein substances (a) to (c) are employed in a total amount of from about 0.01% to about 1% by weight, based on a total weight of the preparation.

20. The preparation of claim 10, wherein substances (a) to (c) are employed in a total amount of from about 0.015% to about 0.1% by weight, based on a total weight of the preparation.

21. The preparation of claim 1, wherein a weight ratio of substances (a) and (c) is from about 35:

1 to about 3;

1.

22. The preparation of claim 2, wherein a weight ratio of substances (a) and (c) is from about 20:

1 to about 6;

1.

23. The preparation of claim 7, wherein a weight ratio of substances (a) and (c) is from about 10:

1 to about 8;

1.

24. The preparation of claim 1, wherein a weight ratio of substances (a) and (b) is from about 10:

1 to about 1.5;

1.

25. The preparation of claim 22, wherein a weight ratio of substances (a) and (b) is from about 7:

1 to about 2.5;

1.

26. The preparation of claim 23, wherein a weight ratio of substances (a) and (b) is from about 5:

1 to about 3.5;

1.

27. The preparation of claim 1, wherein a weight ratio of substances (b) and (c) is from about 10:

1 to about 1;

1.

28. The preparation of claim 2, wherein a weight ratio of substances (b) and (c) is from about 5:

1 to about 1.5;

1.

29. The preparation of claim 22, wherein a weight ratio of substances (b) and (c) is from about 3:

1 to about 2;

1.

30. The preparation of claim 1, wherein the preparation comprises one or more skin cell culture media.

31. The preparation of claim 30, wherein the skin cell culture media comprise at least one of DMEM/HAM F12 (1:

1) and MCDB 153.

32. The preparation of claim 1, wherein the preparation comprises at least one of a nanosponge matrix and a microsponge matrix of substances (a) to (c) which is reconstituted in cell culture media.

33. The preparation of claim 32, wherein the cell culture media are selected from one or more of physiological saline solution, nutrient media and complete media for culturing primary body cells.

34. The preparation of claim 30, wherein the one or more skin culture media comprise culture media for at least one of primary fibroblasts and keratinocytes.

35. The preparation of claim 33, wherein the complete media are supplemented with serum substitutes.

36. The preparation of claim 1, wherein the preparation further comprises a citrate buffer.

37. The preparation of claim 1, wherein the preparation further comprises at least one of Q10, alpha-glucosyl rutin, an alpha-hydroxy acid, Zn orotate, carnitine, creatine and taurine.

38. The preparation of claim 1, wherein the preparation further comprises water.

39. The preparation of claim 7, wherein the preparation comprises at least about 30% by weight of water, based on a total weight of the preparation.

40. The preparation of claim 10, wherein the preparation comprises at least about 50% by weight of water, based on a total weight of the preparation.

41. A cosmetic or dermatological product which comprises the preparation of claim 1 and is selected from an aqueous gel, an O/W emulsion, a W/O/W emulsion, a W/O emulsion, a microemulsion and a cosmetic stick.

42. A cosmetic or dermatological product which comprises the preparation of claim 1 and is selected from an aqueous surfactant preparation, an emulsion, an ointment, a cream, a gel, a dusting powder, a mask, a matrix bandage, a gel bandage, a foam and an aerosol preparation.

43. An article which comprises the preparation of claim 1 and is selected from a wound covering, a skin covering, a patch, a pad, a tissue and a bandage.

44. A polyurethane matrix which comprises the preparation of claim 1.

56. A skin care method, wherein the method comprises applying to skin the preparation of claim 1.

57. A skin treatment method, wherein the method comprises applying to one of injured and diseased skin the preparation of claim 1.

58. A method of wound management or wound healing, wherein the method comprises applying to a wound the preparation of claim 1.

59. The method of claim 58, wherein the preparation is comprised in a wound covering.

60. The method of claim 59, wherein the wound covering comprises a polyurethane.

61. A method of generating a complete partial skin, wherein the method comprises applying the preparation of claim 1 to a surface of a body from which skin has been removed.

62. A method of preventing or reducing scar tissue, wherein the method comprises applying to a wound the preparation of claim 1.

65. The process of claim 61, wherein the glycosylaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

66. The process of claim 65, wherein the collagen comprises one or more collagens selected from types 1, 3, 4 and 5.

67. The process of claim 66, wherein the chitosan comprises chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol.

45. A cosmetic or dermatological preparation which is obtainable by combining substances comprising

(a) at least one of collagen and a derivative thereof;

(b) at least one of chitosan and an acetyl derivative thereof, having a degree of acetylation of up to about 50%;

(c) at least one of a glycosylaminoglycan and a derivative thereof; and

(d) at last four substances selected from glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and glycine; and

(e) at least 50% by weight of water, based on a total weight of the preparation;

wherein substances (a) to (c) are employed in a total amount of from about 0.005% to 10% by weight, based on a total weight of the preparation, substances (a) and (b) are employed in a weight ratio of from about 6;

1 to about 3;

1 and substances (a) and (c) are employed in a weight ratio of from about 15;

1 to about 7;

1.

46. The preparation of claim 45, wherein all of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine and glycine are employed.

47. The preparation of claim 45, wherein substances (a) to (c) are employed in a total amount of from about 0.015% to about 0.1% by weight.

48. The preparation of claim 47, wherein a weight ratio of substances (a) and (c) is from about 10:

1 to about 8;

1.

49. The preparation of claim 48, wherein a weight ratio of substances (a) and (b) is from about 5:

1 to about 3.5;

1.

50. The preparation of claim 49, wherein a weight ratio of substances (b) and (c) is from about 3:

1 to about 2;

1.

51. The preparation of claim 45, wherein there are further employed one or more substances selected from α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, ZnSO₄, L-alanine, L-asparagine, L-aspartic acid, L-cysteine, L-cystine, glycine, L-glutamine, L-glutamic acid, L-tryptophan, L-isoleucine, L-leucine, L-methionine, L-phenylalanine, L-proline, L-tyrosine and L-valine.

52. The preparation of claim 45, wherein the collagen comprises one or more collagens selected from types 1, 3, 4 and 5.

53. The preparation of claim 52, wherein the chitosan comprises chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol.

54. The preparation of claim 53, wherein the glycosylaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

55. The preparation of claim 45, wherein the preparation comprises one or more cell culture media.

63. A process for preparing a cosmetic or dermatological preparation comprising at least one of collagen and a derivative thereof;

at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%; and

at least one of a glycosylaminoglycan and a derivative thereof, wherein the process comprises

(a) providing a solution comprising water and at least one of collagen and a derivative thereof;

(b) adding at least one of chitosan and an acetyl derivative thereof with a degree of acetylation of up to about 50%, to the solution of (a) to form a mixture; and

(c) adding at least one of a glycosylaminoglycan and a derivative thereof to the mixture of (b) to form a further mixture;

(d) combining at least one substance selected from amino acids, α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, folic acid, glucose, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, and ZnSO₄ with one or more of the solution and mixtures according to (a) to (c).

64. The process of claim 63, wherein the solution of (a) comprises one or more cell culture media.

68. The process of claim 63, wherein the process further comprises

(d) lyophilizing the mixture of (c) to provide an aerogel.

69. The process of claim 68, wherein the process further comprises converting the aerogel of (d) into a hydrogel by introducing the aerogel into at least one of an aqueous phase, an active ingredient phase and a culture media phase of the cosmetic or dermatological preparation.

70. The process of claim 68, wherein the process further comprises processing the aerogel of (d) into a polyurethane matrix.