Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents
First Claim
Patent Images
1. An osmotic controlled release dosage form comprising a drug composition comprising:
- a low solubility and/or low dissolution rate free acid pharmaceutical agent, and a pharmaceutically acceptable salt thereof.
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Abstract
An osmotic controlled release dosage form is described comprising a core comprising a first drug composition, wherein the first drug composition comprises topiramate and/or its pharmaceutically acceptable salt; a semi-permeable wall surrounding the core; and an exit orifice through the semi-permeable wall for releasing the first drug composition from the dosage form over a prolonged period of time.
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12 Claims
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1. An osmotic controlled release dosage form comprising a drug composition comprising:
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a low solubility and/or low dissolution rate free acid pharmaceutical agent, and a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 4)
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5. An osmotic controlled release dosage form comprising
a core comprising a first drug composition, wherein the first drug composition comprises a low solubility and/or low dissolution rate free acid pharmaceutical agent and/or its pharmaceutically acceptable salt; -
a semi-permeable wall surrounding the core; and
an exit orifice through the semi-permeable wall for releasing the first drug composition from the dosage form over a prolonged period of time - View Dependent Claims (6, 7, 8)
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9. An osmotic controlled release dosage form comprising
a core comprising a first drug composition, a second drug composition and a push layer, wherein the first and second drug composition each comprise a low solubility and/or low dissolution rate free acid pharmaceutical agent and/or its pharmaceutically acceptable salt; -
a semi-permeable wall surrounding the core; and
an exit orifice through the semi-permeable wall for releasing the first and second drug compositions from the dosage form over a prolonged period of time. - View Dependent Claims (10, 11, 12)
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Specification