Novel ligands and libraries of ligands

• US 20050287596A9
• Filed: 05/10/2002
• Published: 12/29/2005
• Est. Priority Date: 06/26/1998
• Status: Abandoned Application

• Current Assignee: Sunesis Pharmaceuticals, Inc. (Viracta Therapeutics, Inc.)
• Original Assignee: Sunesis Pharmaceuticals, Inc. (Viracta Therapeutics, Inc.)
• Inventors: Jacobs, Jeffrey W., Erlanson, Daniel A., Braisted, Andrew C.
• Application Number:
  US10/143,455
• Publication Number:
  US 20030013125A1
• Time in Patent Office: Days
• US Class Current: 435/7.1
• CPC Class Codes: C07D 207/46 with hetero atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 333/38 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 333/70 attached in position 2
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C40B 20/08 Direct analysis of the library members per se by physical methods, e.g. spectroscopy
• CPC Class Codes: C40B 30/04 by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• CPC Class Codes: C40B 40/04 Libraries containing only organic compounds
• CPC Class Codes: G01N 33/6845 Methods of identifying protein-protein interactions in protein mixtures
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The present invention provides compounds and libraries of compounds having formula (I): wherein L, n, S and A are defined generally and subsets herein. These compounds and libraries of compounds are useful generally in the drug discovery process.

Claims

1. A compound having the structure (I):

2. The compound of claim 1, wherein L is one of the following structures:

3. The compound of claim 1, wherein

4. The compound of claim 1, wherein

5. The compound of claim 4, whereinR^A2 is methyl or phenyl.

6. The compound of claim 1, wherein one or both of R¹ or R² is

7. The compound of claim 1, wherein L is

8. The compound of claim 1, wherein L is

9. The compound of claim 1, wherein L is

10. The compound of claim 1, wherein L is

11. The compound of claim 1, wherein L is

12. The compound of claim 1, wherein L is

13. The compound of claim 1, wherein L is

14. The compound of claim 1, wherein L is

15. The compound of claim 1, wherein L is

16. The compound of claim 1, wherein L is

17. The compound of claim 1, wherein L is

18. The compound of claim 1, wherein L is

19. The compound of claim 18, wherein the substituted heteroaryl moiety has one of the structures:

20. The compound of claim 19, wherein R¹ and R² represent one of the following structures:

49. A method for ligand discovery comprising:

contacting a target that comprises a chemically reactive group at or near a site of interest with a compound of claim 1 that is capable of forming a covalent bond with a chemically reactive group;

forming a covalent bond between the target and the compound thereby forming a target-compound conjugate; and

identifying the target compound conjugate.

21. A library of compounds comprising a plurality of compounds having the structure (I):

22. The library of claim 21, wherein L is one of the following structures:

23. The library of claim 21, wherein

24. The library of claim 21, wherein

25. The library of claim 24, wherein R^A2 is methyl or phenyl.

26. The library of claim 21, wherein one or both of R¹ or R² is

27. The library of claim 21, wherein L is

28. The library of claim 21, wherein L is

29. The library of claim 21, wherein L is

30. The library of claim 21, wherein L is

31. The library of claim 21, wherein L is

32. The library of claim 21, wherein L is

33. The library of claim 21, wherein L is

34. The library of claim 21, wherein L is

35. The library of claim 21, wherein L is

36. The library of claim 21, wherein L is

37. The library of claim 21, wherein L is

38. The library of claim 21, wherein L is

39. The compound of claim 38, wherein the substituted heteroaryl moiety has one of the structures:

40. The library of claim 39, wherein R¹ and R² represent one of the following structures:

41. The library of claim 21, wherein the library comprises at least 5 members.

42. The library of claim 21, wherein the library comprises at least 20 members.

43. The library of claim 21, wherein the library comprises at least 100 members.

44. The library of claim 21, wherein the library comprises at least 500 members.

45. The library of claim 21, wherein the library comprises at least 1000 members.

46. The library of claim 21, wherein each member has a different molecular weight.

47. The library of claim 21, wherein each member has a mass that differs from another member by at least 5 atomic mass units.

48. The library of claim 21, wherein each member has a mass that differs from another member by at least 10 atomic mass units.