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RNA interference compositions and screening methods for the identification of novel genes and biological pathways

  • US 20050287668A1
  • Filed: 10/29/2004
  • Published: 12/29/2005
  • Est. Priority Date: 11/04/2003
  • Status: Abandoned Application
First Claim
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1. A method of reducing nonspecific suppression of gene expression in response to an introduced double-stranded polynucleotide, comprising:

  • (a) introducing an agent that attenuates a pathway of nonspecific suppression into a cell; and

    (b) introducing an RNAi molecule that induces nonspecific suppression of gene expression into the cell, wherein said agent reduces nonspecific suppression of gene expression induced by said double-stranded polynucleotide.

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