Silicone polymer topical eye compositions and methods of use

• US 20050288197A1
• Filed: 06/08/2005
• Published: 12/29/2005
• Est. Priority Date: 06/08/2004
• Status: Abandoned Application

• Current Assignee: Ocularis Pharma, LLC
• Original Assignee: Ocularis Pharma, LLC
• Inventors: Horn, Gerald
• Application Number:
  US11/148,052
• Publication Number:
  US 20050288197A1
• Time in Patent Office: Days
• US Class Current: 510/112
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61L 12/08 using chemical substances
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions

Abstract

The present invention is an eye preparation comprising a hydrophobic composition adapted for use on a patient'"'"'s eye and having a viscosity of 1 to 15,000 centistokes. The composition includes a silicone polymer, fluorinated silicone polymer, fluorocarbon polymer, fluorinated alcohol, or perfluorinated polyether composition, singly or blended, adapted to coat at least a portion of a patient'"'"'s eye. Silicone polymers for use in the invention include dimethicone, cyclomethicone, and silicone gums.

Claims

1. An eye preparation comprising a hydrophobic composition adapted to treat a subject'"'"'s eye.

2. The eye preparation of claim 1 wherein the composition has a viscosity of 1 to 15,000 centistokes.

3. The eye preparation of claim 1 wherein the composition has a viscosity of 1 to 8,000 centistokes.

4. The eye preparation of claim 1 wherein the composition is applied directly to a subject'"'"'s eye.

5. The eye preparation of claim 1 wherein the composition is in the form of a liquid, a gel, or an emulsion.

6. The eye preparation of claim 1 wherein the composition is adapted to treat a defect of an ocular epithelium.

7. The eye preparation of claim 1 wherein the composition further comprises a therapeutic agent.

8. The eye preparation of claim 7 wherein the therapeutic agent is lipophilic.

9. The eye preparation of claim 7 wherein the therapeutic agent is a sunscreen.

10. The eye preparation of claim 7 wherein the therapeutic agent is a slow release formulation.

11. The eye preparation of claim 1 wherein the composition is oxygen permeable.

12. The eye preparation of claim 1 wherein the composition comprises a silicone polymer.

13. The eye preparation of claim 12 wherein the silicone polymer comprises dimethicone.

14. The eye preparation of claim 12 wherein the silicone polymer comprises cyclomethicone.

15. The eye preparation of claim 12 wherein the silicone polymer comprises a blend of at least two of dimethicone, cyclomethicone, and silicone gum.

16. The eye preparation of claim 12 wherein the silicone polymer is fluorinated.

17. The eye preparation of claim 16 wherein increasing the fluorine concentration of the silicone polymer increases the oleophobicity of the composition.

18. The eye preparation of claim 16 wherein the fluorinated silicone polymer is perfluorosilicone.

19. The eye preparation of claim 18 wherein the perfluorosilicone is perfluorononyl dimethicone.

20. The eye preparation of claim 12 wherein the silicone polymer further comprises at least one of perfluorocarbon polymer and perfluoroalkane polymer.

21. The eye preparation of claim 1 wherein the composition comprises a perfluorocarbon polymer.

22. The eye preparation of claim 21 wherein the perfluorocarbon polymer is perfluoro-n-octane.

23. The eye preparation of claim 21 wherein the perfluorocarbon polymer is a perfluoroalkane polymer.

24. The eye preparation of claim 1 wherein the composition comprises a fluorinated alcohol.

25. The eye preparation of claim 24 wherein the fluorinated alcohol is dioctyldodecylfluoroheptyl citrate.

26. The eye preparation of claim 1 wherein the composition comprises a perfluorinated polyether.

27. The eye preparation of claim 26 wherein the perfluorinated polyether is Fomblin Z.

28. The eye preparation of claim 26 wherein the perfluorinated polyether is Fomblin Z-DOL.

29. The eye preparation of claim 1 wherein the composition comprises a blend of at least two of silicone polymer, fluorinated silicone polymer, perfluorocarbon polymer, fluorinated alcohol, and perfluorinated polyether.

30. The eye preparation of claim 1 wherein the composition is contained within a single or multi dose applicator.

31. The eye preparation of claim 1 wherein the composition reduces symptoms associated with dry eye.

32. The eye preparation of claim 1 wherein the composition protects the ocular epithelium from abrasion.

33. The eye preparation of claim 1 wherein the composition is clear in color.

34. A method for delivering a hydrophobic composition to a subject'"'"'s eye, said method comprising the steps of:

providing a hydrophobic composition; and

introducing the hydrophobic composition to the eye;

wherein the composition is introduced in an amount sufficient to deposit a microfilm of the composition over at least a portion of the subject'"'"'s eye.