Method for protecting resonating sensors and open protected resonating sensors

• US 20050288590A1
• Filed: 06/28/2004
• Published: 12/29/2005
• Est. Priority Date: 06/28/2004
• Status: Active Grant

• Current Assignee: MicroTech Medical Technologies Ltd.
• Original Assignee: Zuli Holdings, Ltd.
• Inventors: Kaplan, Shay
• Granted Patent: US 7,415,883 B2
• Time in Patent Office: Days
• US Class Current: 600/459
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: A61B 5/6882 Anchoring means

Abstract

A protected resonating sensor may include at least one resonating sensor unit, each sensor unit has one or more vibratable members. The protected sensor includes at least one body of gel for protecting the vibratable member(s) of the sensor. The gel may be disposed on or attached to the sensor unit(s) covering the vibratable member(s) of the sensor unit(s). The gel may also be disposed in an open housing including one or more sensor units, and may cover vibratable members of different sensor units. The sensor unit may be any resonating sensor unit having a resonance frequency that depends on the value of a physical variable in a measurement environment. The protected sensor may also be attached to or included in or formed as part of any suitable device or sensor anchoring device and may also be implanted or inserted into a body or an organism. Methods are described for constructing the gel-protected sensor. The gel may have modified surface properties and may contain one or more drugs or therapeutic agents or other releasable substances. The gel may be formulated to retard or reduce diffusion of substances from the measurement environment into the gel and their deposition on the vibratable member(s).

Claims

1. A protected resonating sensor comprising:

one or more resonating sensor units, each sensor unit of said one or more resonating sensor units has at least one vibratable member having a resonance frequency that varies as a function of a physical variable in a measurement environment; and

at least one body of gel in contact with said at least one vibratable member of said one or more resonating sensor units.

2. The protected sensor according to claim 1 wherein the acoustic impedance of said at least one body of gel is close to or equal to the acoustic impedance of the medium disposed in said measurement environment.

3. The protected sensor according to claim 1 wherein said protected sensor is an implantable sensor configured to be implanted in a body or organism, and wherein the acoustic impedance of said at least one body of gel is close to or equal to the acoustic impedance of one or more tissues of said body or organism.

4. The protected sensor according to claim 1 wherein said one or more resonating sensor units are embedded in said at least one body of gel.

5. The protected sensor according to claim 1 wherein said at least one body of gel completely covers all the vibratable members included in said one or more resonating sensor units.

6. The protected sensor according to claim 1 wherein said at least one body of gel is selected from a synthetic gel, a natural gel, a hydrogel, a lipogel, a hydrophobic gel, a hydrophilic gel, a biocompatible gel, a hemocompatible gel, a polymer based gel, a cross-linked polymer based gel and combinations thereof.

7. The protected sensor according to claim 1 wherein said protected sensor further includes a housing.

8. The protected sensor according to claim 7 wherein said at least one body of gel at least partially fills said housing.

9. The protected sensor according to claim 1 wherein said at least one body of gel comprises at least one thin layer of gel attached to said at least one vibratable member of said one or more resonating sensor units.

10. The protected sensor according to claim 1 wherein said one or more resonating sensor units are disposed within at least one open chamber.

11. The protected sensor according to claim 1 wherein said at least one chamber is selected from,

at least one chamber formed within a sensor anchoring device, and

at least one chamber comprising part of a sensor anchoring device.

12. The protected sensor according to claim 11 wherein said sensor anchoring device is selected from a sensor anchor, a sensor positioner, an implantable graft, a sensor fixating device, an implant, an implantable device, an implantable graft, a part of an implantable device, a pacemaker, a part of a pacemaker, a defibrillator, a part of a defibrillator, an implantable electrode, an insertable electrode, an endoscopic device, a part of an endoscopic device, an autonomous endoscopic device, a part of an autonomous endoscopic device, a tethered endoscopic device, a part of a tethered endoscopic device, an implantable catheter, an insertable catheter, a stent, a part of a stent, a guide-wire, a part of a guide-wire, an implantable therapeutic substance releasing device, and an insertable therapeutic substance releasing device.

13. The protected sensor according to claim 1 wherein said at least one resonating sensor unit is selected from a passive sensor unit, an active sensor unit, a passive resonating sensor unit, an active resonating sensor unit, a pressure sensor, a passive ultrasonic pressure sensor, an active ultrasonic pressure sensor, and a sensor for sensing the concentration of a chemical species in a measurement environment.

14. The protected sensor according to claim 1 wherein at least one resonating sensor unit of said one or more resonating sensor units comprises,

a substrate having one or more recesses formed therein, and

a second layer sealingly attached to said substrate to form one or more sealed sensor unit chambers within said at least one resonating sensor unit.

15. The protected sensor according to claim 14 wherein said at least one vibratable member of said at least one resonating sensor unit is selected from,

at least one vibratable member comprising a portion of said substrate, and

at least one vibratable member comprising a portion of said second layer overlying said one or more recesses.

16. The protected sensor according to claim 14 wherein each sealed sensor unit chamber of said one or more sealed sensor unit chambers has a pressure level therewithin.

17. The protected sensor according to claim 16 wherein said pressure level is selected from a zero pressure level and a non-zero pressure level.

18. The protected sensor according to claim 16 wherein said protected sensor comprises a first resonating sensor unit having one or more sealed sensor unit chambers and at least a second resonating sensor unit having one or more sealed sensor unit chambers, and wherein the pressure level within at least one sealed sensor unit chamber of said first resonating sensor unit is different than the pressure level within at least one sealed sensor unit chamber of said at least second resonating sensor unit.

19. The protected sensor according to claim 1 wherein said one or more resonating sensor units are selected from,

at least one passive ultrasonic pressure sensor unit having a single vibratable membrane, and

at least one passive ultrasonic pressure sensor unit having multiple vibratable membranes.

20. The protected sensor according to claim 1 wherein said protected sensor is an implantable protected sensor.

21. The protected sensor according to claim 20 wherein one or more of the components of said implantable protected sensor comprises one or more materials selected from biocompatible materials and hemocompatible materials.

22. The protected sensor according to claim 20 wherein said protected sensor is configured for implantation within a measurement environment selected from, an eye, a urether, a cardiac chamber, a cardiovascular system, a part of a cardiovascular system, an annurismal sac after endovascular repair, a spine, an intervertebral disc, a spinal cord, a spinal column, an intracranial compartment, an intraluminal space of a blood vessel, an artery, a vein, an aorta, a pulmonary blood vessel, a carotid blood vessel, a brain blood vessel, and a coronary artery, a femoral artery, an iliac artery, a hepatic artery, a renal artery and a vena cava.

23. The protected sensor according to claim 1 wherein at least part of the surface of said protected sensor is a modified surface having modified surface properties.

24. The protected sensor according to claim 23 wherein said modified surface properties are selected from physical surface properties, chemical surface properties, electrochemical surface properties, biological surface properties, surface resistance to deposition of cells or tissues thereon, Theological surface properties, and any combinations thereof.

25. The protected sensor according to claim 23 wherein said modified surface is a chemically treated surface.

26. The protected sensor according to claim 23 wherein said protected sensor also includes at least one non-resonating sensor unit.

27. The protected sensor according to claim 23 wherein said modified surface is a surface of said at least one body of gel.

28. The protected sensor according to claim 1 wherein said at least one body of gel comprises at least one releasable substance.

29. The protected sensor according to claim 28 wherein said at least one releasable substance is selected from the group consisting of a protein, a peptide, a drug, a therapeutic agent, a polysaccharide, a lipid, a glycolipid, a lipoprotein, a glycoprotein, a proteoglycans, an extracellular matrix component, a nucleic acid, a polynucleotide, RNA, DNA, an anti-sense nucleic acid sequence, a receptor, an enzyme, an antibody, an antigen, an enzyme inhibitor, a cell proliferation inhibitor, a growth regulating factor, a growth inhibiting factor, a growth promoting factor, an anti-coagulant agent, an anti-clotting agent, a tumor inhibiting drug, a tumor inhibiting factor, a tumor suppressing agent, an anti-cancer drug, and any combinations thereof.

30. The protected sensor according to claim 1 wherein said at least one body of gel comprises a substantially non-compressible gel.

31. The protected sensor according to claim 1 wherein said at least one body of gel comprises a gel having a composition capable of retarding or reducing the diffusion of one or more substances into said gel.

32. The protected sensor according to claim 1 wherein said at least one body of gel comprises a gel having a composition capable of retarding or reducing the deposition of one or more substances onto said at least one vibratable member of said one or more resonating sensor units.

33. A protected sensor comprising at least one resonating sensor unit, each sensor unit of said at least one resonating sensor unit has at least one vibratable member having a resonance frequency that varies as a function of a physical variable in a measurement environment, wherein at least one vibratable member of said at least one resonating sensor unit is protected by a gel attached thereto.

34. A method for constructing a protected a resonating sensor the method comprising the steps of:

Providing one or more resonating sensor units, each sensor unit of said one or more resonating sensor units has at least one vibratable member having a resonance frequency that varies as a function of a physical variable in a measurement environment; and

Attaching at least one body of gel to said one or more resonating sensor units.

35. The method according to claim 34 wherein said step of attaching comprises covering all the vibratable members of said one or more resonating sensor units with said gel.

36. The method according to claim 34 wherein said step of attaching comprises,

applying a liquefied gel to cover at least all the vibratable members of said one or more resonating sensor units with said liquefied gel, and

allowing said liquefied gel to solidify.

37. The method according to claim 36 wherein said liquefied gel is obtained by heating a liquefiable gel.

38. The method according to claim 34 wherein said step of attaching comprises,

applying a liquid comprising at least one gel precursor to cover at least all the vibratable members of said one or more resonating sensor units with said liquid, and

allowing said at least one body of gel to form from said liquid.

39. The method according to claim 34 wherein said at least one gel precursor comprise at least one monomer capable of being polymerized to form said at least one body of gel.

40. The method according to claim 34 wherein said step of attaching comprises embedding said one or more resonating sensor units within said at least one body of gel.

41. The method according to claim 34 wherein said step of attaching comprises completely embedding or partially embedding said one or more resonating sensor units in said at least one body of gel wherein said at least one body of gel is attached to a surface.

42. The method according to claim 41 wherein said surface is selected from, a surface of a sensor housing, a surface of a sensor anchoring device, a surface of an implantable graft, a surface of an implantable device, a surface of an implant, a surface of an insertable device, and a surface of an enclosure surrounding a measurement environment.

43. The method according to claim 34 wherein the acoustic impedance of said gel is close to or equal to the acoustic impedance of a medium contained in a measurement environment in which said protected sensor is disposed.

44. The method according to claim 34 wherein said protected sensor is an implantable protected sensor configured for implantation within an organism, and wherein the acoustic impedance of said gel is close to or equal to the acoustic impedance of at least one tissue or bodily fluid of said organism.

45. The method according to claim 34 wherein said step of attaching comprises,

disposing said one or more resonating sensor units in a housing,

At least partially filling said housing with a liquid comprising at least one gel precursor to cover at least a vibratable member of said one or more resonating sensor units with said liquid, and

allowing said at least one body of gel to form from said liquid.

46. The method according to claim 34 wherein said protected resonating sensor further comprises at least one non-resonating sensor unit. and wherein said step of attaching comprises attaching said at least one non-resonating sensor unit to said at least one body of gel.

47. The method according to claim 34 further including the step of treating at least part of the surface of said protected sensor for modifying the surface properties of said at least part of said protected sensor.

48. The method according to claim 47 wherein said step of treating is performed on said at least one body of gel to change the surface properties thereof.

49. The method according to claim 47 wherein said surface properties are selected from physical surface properties, chemical surface properties, electrochemical surface properties, biological surface properties, surface resistance to deposition of cells or tissues thereon, rheological surface properties, and any combinations thereof.

50. The method according to claim 47 wherein said step of treating comprises chemically treating said at least part of the surface of said protected sensor for modifying the surface properties thereof.

51. The method according to claim 34 further including the step of incorporating at least one releasable substance in said at least one body of gel.

52. The method according to claim 51 wherein said at least one releasable substance is selected from the group consisting of a protein, a peptide, a drug, a therapeutic agent, a polysaccharide, a lipid, a glycolipid, a lipoprotein, a glycoprotein, a proteoglycans, an extracellular matrix component, a nucleic acid, a polynucleotide, RNA, DNA, an anti-sense nucleic acid sequence, a receptor, an enzyme, an antibody, an antigen, an enzyme inhibitor, a cell proliferation inhibitor, a growth regulating factor, a growth inhibiting factor, a growth promoting factor, an anti-coagulant agent, an anti-clotting agent, a tumor inhibiting drug, a tumor inhibiting factor, a tumor suppressing agent, an anti-cancer drug, and any combinations thereof.

53. The method according to claim 51 wherein said step of incorporating comprises adding said at least one releasable substance to said gel prior to disposing said gel in said protected sensor.

54. The method according to claim 53 wherein said step of adding is selected from, adding said at least one releasable substance to a liquid gel precursor, and adding said at least one releasable substance to a liquefied gel.

55. The method according to claim 51 wherein said step of incorporating comprises introducing said at least one releasable substance to said gel after disposing said gel in said protected sensor.

56. The method according to claim 55 wherein said step of introducing comprises diffusing said at least one releasable substance into said at least one body of gel.

57. The method according to claim 56 wherein said diffusing comprises incubating said protected sensor in a solution comprising said at least one releasable substance.

58. A method for constructing a protected a resonating sensor, the method comprising the steps of:

providing one or more resonating sensor units, each sensor unit of said one or more resonating sensor units has at least one vibratable member having a resonance frequency that varies as a function of a physical variable in a measurement environment; and

covering said at least one vibratable member of said one or more resonating sensor units with a gel.

59. A method for constructing a protected a resonating sensor, the method comprising the steps of:

providing one or more resonating sensor units, each sensor unit of said one or more resonating sensor units has at least one vibratable member having a resonance frequency that varies as a function of a physical variable in a measurement environment; and

providing a gel in contact with said at least one vibratable member of said one or more resonating sensor units.

60. A method for protecting a resonating sensor unit having one or more vibratable members, the method comprises the step of covering at least said one or more vibratable members of said sensor unit with a gel.

61. A method for protecting a resonating sensor unit having one or more vibratable members, the method comprises the step of covering at least one vibratable member of said sensor unit with a gel.