Methods of electrotransport drug delivery
First Claim
Patent Images
1. A method of varying the delivery rate of a drug comprising:
- providing a plurality electrotransport delivery reservoirs, each reservoir adapted to be placed in drug-transmitting contact with a subject body surface for delivering the drug through the body surface by means of an electrotransport current (i) applied to the reservoir via a reservoir-contacting electrode, the reservoir being permeable to electrically assisted flux of the drug, each of the reservoirs containing the same drug and the geometry of each of the reservoirs being defined by at least three parameters including average cross-sectional area ARES, average thickness, and body surface contact area ABODY;
arranging an electronic controller including an electronic circuit adapted to control the electrotransport current applied to the reservoirs so that the controller can be connected to each of the plurality of reservoirs; and
varying at least one of the parameters for one of the plurality of reservoirs so that the varied parameter is different than the same parameter for another of the plurality of reservoirs such that the delivery rate from one of the plurality of reservoirs is different than the delivery rate of another of the plurality of reservoirs.
1 Assignment
0 Petitions
Accused Products
Abstract
A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of the same reservoir configurations and drug formulations. A method of making a reservoir and a family of reservoirs and incorporating them into an electrotransport system is disclosed.
-
Citations
19 Claims
-
1. A method of varying the delivery rate of a drug comprising:
-
providing a plurality electrotransport delivery reservoirs, each reservoir adapted to be placed in drug-transmitting contact with a subject body surface for delivering the drug through the body surface by means of an electrotransport current (i) applied to the reservoir via a reservoir-contacting electrode, the reservoir being permeable to electrically assisted flux of the drug, each of the reservoirs containing the same drug and the geometry of each of the reservoirs being defined by at least three parameters including average cross-sectional area ARES, average thickness, and body surface contact area ABODY;
arranging an electronic controller including an electronic circuit adapted to control the electrotransport current applied to the reservoirs so that the controller can be connected to each of the plurality of reservoirs; and
varying at least one of the parameters for one of the plurality of reservoirs so that the varied parameter is different than the same parameter for another of the plurality of reservoirs such that the delivery rate from one of the plurality of reservoirs is different than the delivery rate of another of the plurality of reservoirs. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
- 11. A method of providing a variety of drug delivery regimens for a drug comprising providing a family of electrotransport delivery reservoirs, each of the reservoirs adapted to be placed in drug-transmitting contact with a subject body surface for delivering the drug through the body surface by means of an electrotransport current applied to the reservoir via a reservoir-contacting electrode, the reservoir being permeable to electrically assisted flux of the drug, each of the reservoirs containing the same drug, wherein one of the reservoirs has a geometrical parameter that is different from the same geometrical parameter of another of the family of reservoirs and connecting each of the family of reservoirs at different times to an electronic controller including an electronic circuit adapted to control the electrotransport current applied to the reservoirs such that the drug delivery regimen from one of the family of reservoirs is different from the drug delivery regimen from another of the family of reservoirs.
-
16. A method of varying the drug delivery from an electrotransport drug delivery reservoir comprising providing a family of reservoirs, each reservoir adapted to be placed in drug-transmitting contact with a subject body surface for delivering a drug through the body surface by means of an electrotransport current applied to the reservoir via a reservoir-contacting electrode, the reservoir being permeable to electrically assisted flux of the drug, wherein at least two reservoirs have the same geometrical dimensions;
-
varying the body contact areas of the at least two reservoirs having the same geometrical dimensions by placing a mask over a portion of one of the two reservoirs having the same geometrical dimensions so that application of the same current to the two reservoirs results in a different drug delivery rate from the two reservoirs; and
electrically connecting the at least two reservoirs having the same geometrical dimensions to an electronic controller including an electronic circuit adapted to control the electrotransport current applied to the at least two reservoirs. - View Dependent Claims (17, 18, 19)
-
Specification