Medical treatment system using biological regulation function alternate, cardiac pacing system based on the medical treatment system, blood pressure regulating system, and cardiac disease treating system

• US 20050288718A1
• Filed: 08/05/2002
• Published: 12/29/2005
• Est. Priority Date: 08/05/2002
• Status: Active Grant

• Current Assignee: Fujikin Incorporated, National Cerebral And Cardiovascular Center
• Original Assignee: National Cardiovascular Center Japan
• Inventors: Sugimachi, Masaru, Sunagawa, Kenji, Sato, Takayuki
• Granted Patent: US 7,835,791 B2
• Time in Patent Office: Days
• US Class Current: 607/9
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A medical treating system based on biological activities characterized by biological activity sensing means for sensing biological activity information produced by biological activities and outputting a biological activity signal, calculating means for receiving, analyzing, and processing the biological activity signals from the biological activity sensing means, calculating an organism stimulation signal, and outputting the organism stimulation signal, and organism stimulating means for receiving the organism stimulation signal calculated by the calculating means and stimulating an organism according to the organism stimulation signal. A cardiac pacing system based on the treating system, a blood pressure regulating system, and a cardiac disease treating system are also disclosed.

Claims

1. (canceled)

2. (canceled)

3. (canceled)

4. (canceled)

5. (canceled)

6. (canceled)

7. A system to treat diseases based on biological activities, comprising:

a) at least one biological activity sensing means which senses biological activity information issued by biological activities, and outputs a plurality of biosignals;

b) a calculating means which receives the biosignals, calculates a plurality of signals for stimulation of an organism using a convolution integral between at least one impulse response previously obtained from normal biological activities and the biosignals, and outputs the signals for stimulation of the organism; and

c) an organism stimulating means which receives the signals for stimulation of the organism, and stimulates the organism based on those signals.

8. The system of claim 7, wherein the biological activity sensing means is selected from the group consisting of electrodes and pressure sensors.

9. The system of claim 7, wherein the biosignals are selected from the group consisting of sympathetic nerve activities, parasympathetic nerve activities, blood flow, blood pressure, body temperature, electrocardiogram, electroenchephalogram, and various biochemical markers.

10. The system of claim 7, wherein the organism stimulating means stimulates in a manner selected from the group consisting of electrical stimulation;

and

stimulation with the use of devices for drug administration.

11. The system of claim 7, wherein the calculating means comprises:

at least one amplifier to amplify the biosignal;

at least one analog-to-digital converter, to convert the biosignal from an analog signal to a digital signal; and

at least one analyzer to process data to calculate signals to be transferred to the organism stimulating means.

12. A system to treat diseases based on biological activities, comprising:

a) at least one biological activity sensing means which senses biological activity information issued by biological activities, and outputs a plurality of biosignals;

b) a calculating means which receives the biosignals, calculates a plurality of signals for stimulation of an organism using a convolution integral between an impulse response previously obtained from normal biological activities and the biosignals, and outputs the signals for stimulation of the organism; and

c) an organism stimulating means which receives the signals for stimulation of the organism calculated by the calculating means, and stimulates the organism based on those signals;

wherein the calculating means includes discriminating means which determine whether the biosignals are caused by normal biological activities or by abnormal biological activities;

wherein the calculating means does not output the signals for stimulation of the organism when the biosignals are determined to be caused by normal biological activities; and

wherein the calculating means outputs the signals for stimulation of the organism when the biosignals are determined to be caused by abnormal biological activities.

13. A cardiac pacing system based on biological activities, comprising:

a) at least one nerve activity sensing means which senses nerve activity of a cardiac sympathetic nerve and/or a vagal nerve, and outputs a plurality of nerve activity signals;

b) a calculating means which receives the nerve activity signals, calculates a plurality of pacing signals for a control of a heart rate by a convolution integral between an impulse response previously obtained from normal nerve activities and the nerve activity signals, and outputs the pacing signals; and

c) a pacing means which receives the pacing signals, and stimulates the heart based on the pacing signals such that heart rate is regulated.

14. The system of claim 13, wherein the organism stimulating means is a cardiac pacemaker.

15. A blood pressure regulating system, which uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising:

a) at least one blood pressure sensing means which senses blood pressure and outputs a blood pressure signal;

b) a calculating means which receives the blood pressure signal, analyzes and processes the blood pressure signal to calculate a sympathetic nerve stimulation signal for a regulation of blood pressure by stimulation of a plurality of sympathetic nerve innervating vascular beds, and outputs the sympathetic nerve stimulation signal; and

c) a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.

16. The system of claim 15, wherein the biological activity sensing means is a pressure sensor.

17. The system of claim 15 wherein a site for sympathetic nerve stimulation is selected from the group consisting of sympathetic ganglia;

a surface of a spinal cord; and

at least one site in a brain.

18. A system to treat cardiac diseases based on biological activities, comprising:

a) at least one cardiovascular activity sensing means which senses cardiovascular activity information issued by a cardiovascular system, and outputs a plurality of cardiovascular activity signals;

b) a calculating means which receives the cardiovascular activity signals, analyzes and processes the cardiovascular activity signals to calculate a plurality of nerve stimulation signals, and outputs the nerve simulation signals; and

c) a nerve stimulating means which receives the nerve stimulation signals, and stimulates a nerve based on the nerve stimulation signals.