Method and device for measurement of an event with reagents under partial equilibrium using thermal sensors
First Claim
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1. Method for measuring heat generated by an event between at least two samples, the method comprising:
- providing at least a first sample comprising first components and first reagents of interest and at least a second sample comprising second components and second reagents of interest, the first sample and the second sample being separated by a selective wall, allowing establishment of a partial equilibrium between the first components and the second components through the selective wall, applying a stimulus to the selective wall for allowing occurrence of an event between the first reagent of interest and the second reagent of interest, and measuring heat generated by said event.
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Abstract
The present invention provides a method for measuring the heat of an event between at least two samples being in partial equilibrium. By allowing the samples to first establish a partial equilibrium, the background noise coming from chemical non-equilibrium between components, e.g. buffers, of the samples can be minimised and hence, the signal to noise ratio of the signal that is measured may be improved.
26 Citations
16 Claims
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1. Method for measuring heat generated by an event between at least two samples, the method comprising:
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providing at least a first sample comprising first components and first reagents of interest and at least a second sample comprising second components and second reagents of interest, the first sample and the second sample being separated by a selective wall, allowing establishment of a partial equilibrium between the first components and the second components through the selective wall, applying a stimulus to the selective wall for allowing occurrence of an event between the first reagent of interest and the second reagent of interest, and measuring heat generated by said event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A device for measuring heat generated by an event between at least two samples, comprising:
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a first compartment for comprising a first sample comprising first components and first reagents of interest, a second compartment for comprising a second sample comprising second components and second reagents of interest, a selective membrane separating the first compartment from the second compartment and allowing establishment of a partial equilibrium between the first components and the second components, means for applying a stimulus to the selective membrane for allowing occurrence of an event between the first and second reagents of interest, and means for detecting heat generated by the event between the first and second reagents of interest. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification