Methods for reducing the foreign body reaction
First Claim
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1. An implantable medical device comprising:
- (a) a device body; and
(b) a surface layer attached to the device body, the surface layer comprising an amount of an MMP-9 antagonist sufficient to reduce the foreign body response against the device, wherein the device is adapted to be completely or partially implanted within an animal.
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Abstract
The present invention provides methods for reducing the foreign body reaction against a structure implanted within an animal body. The methods include the step of providing an amount of an MMP-9 antagonist at the site of the implanted structure that is sufficient to reduce the foreign body response against the structure. The invention also provides implantable medical devices that include a surface layer that includes an amount of an MMP-9 antagonist sufficient to reduce the foreign body response against the device.
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Citations
17 Claims
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1. An implantable medical device comprising:
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(a) a device body; and
(b) a surface layer attached to the device body, the surface layer comprising an amount of an MMP-9 antagonist sufficient to reduce the foreign body response against the device, wherein the device is adapted to be completely or partially implanted within an animal. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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- 8. A method of reducing the foreign body reaction against a structure implanted within an animal body, the method comprising the step of providing an amount of an MMP-9 antagonist, at the site of the implanted structure, that is sufficient to reduce the foreign body response against the structure.
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