Hyaluronic acid in the enhancement of lens regeneration
First Claim
1. A method for enhancing regeneration of lens cells in a mammal, comprising:
- providing a composition comprising a hyaluronic acid compound; and
filling a lens capsule bag of said mammal with said composition, wherein said hyaluronic acid compound is formulated to biodegrade or dissolve at least 2 weeks after being filled into said lens capsule bag.
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Abstract
The present invention addresses the treatment of ocular conditions by the enhancement of lens regeneration. This is accomplished by the administration of a high viscosity composition including a hyaluronic acid compound. Excess high viscosity composition may be removed by focal laser photophacoablation. Additionally, a collagen product may be injected within the lens capsule to improve lens cell proliferation and differentiation, and to improve the configuration, shape and structure of regenerated lenses. Various embodiments involving the enhancement of lens regeneration are described. For example, lens regeneration may be enhanced by filling the lens capsule bag with the inventive hyaluronic acid compound; by inserting at least one collagen patch in the lens capsule; and/or by injecting a collagen-based product into the lens capsule.
35 Citations
27 Claims
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1. A method for enhancing regeneration of lens cells in a mammal, comprising:
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providing a composition comprising a hyaluronic acid compound; and
filling a lens capsule bag of said mammal with said composition, wherein said hyaluronic acid compound is formulated to biodegrade or dissolve at least 2 weeks after being filled into said lens capsule bag. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating an ocular condition in a mammal, comprising:
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providing a composition comprising a hyaluronic acid compound; and
filling a lens capsule bag of said mammal with said composition to enhance regeneration of lens cells in said mammal, thereby treating said ocular condition, wherein said hyaluronic acid compound is formulated to dissolve at least 2 weeks after being filled into said lens capsule bag. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for enhancing regeneration of lens cells in a mammal, comprising:
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providing a composition comprising amniotic fluid, in vitro fertilization media, or both; and
filling a lens capsule bag of said mammal with said composition. - View Dependent Claims (22, 23, 24, 25)
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26. A novel enhanced tissue-organized composition of matter, comprising:
a mutliplicity of ribbon-like nucleus free component elements, arranged within a hexagonal pattern effective for growing into a functionally operable regenerated lens means for refracting light.
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27. A regenerated composition of matter, comprising in combination:
alpha, beta, and gamma crystallins arrayed within a hexagonal matrix disposed within a capsular bag, whereby a functional light refracting lens continues to grow therefrom enabling restored visual acuity in a user.
Specification