METHOD OF TREATING BREAST CANCER USING A COMBINATION OF VITAMIN D ANALOGUES AND OTHER AGENTS
First Claim
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1. A method of synergistically inhibiting the growth of human breast cancer cells, comprising contacting the cells with a first composition which comprises 1α
- ,24-dihydroxyvitamin D2 and a second composition which comprises an agent selected from the group consisting of doxorubicin, cisplatin and paclitaxel or combinations thereof.
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Abstract
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the breast, e.g., breast cancer, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
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12 Claims
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1. A method of synergistically inhibiting the growth of human breast cancer cells, comprising contacting the cells with a first composition which comprises 1α
- ,24-dihydroxyvitamin D2 and a second composition which comprises an agent selected from the group consisting of doxorubicin, cisplatin and paclitaxel or combinations thereof.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12-28. -28. (canceled)
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