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One-step enzymatic and amine detection technique

  • US 20060003336A1
  • Filed: 06/30/2004
  • Published: 01/05/2006
  • Est. Priority Date: 06/30/2004
  • Status: Active Grant
First Claim
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1. A diagnostic kit for detecting an amine, enzyme, or an enzyme inhibitor within a test sample, the kit comprising:

  • a plurality of reactive complexes that each comprises a substrate joined to a reporter and a separation species, said substrate being cleavable by an enzyme to release said reporter; and

    a chromatographic medium that defines a first enzyme detection zone within which an enzyme detection signal is capable of being generated, wherein the presence or quantity of an enzyme, or an inhibitor thereof, is determinable from said enzyme detection signal, said chromatographic medium further defining an amine detection zone within which is contained a chemichromic dye, said chemichromic dye being capable of undergoing a color change in the presence of an amine, wherein the presence or quantity of an amine is determinable from said color change.

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