Intermediates and the synthesis of modified carbocyanine dyes and their conjugates
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
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14 Claims
- 1. A compound having the formula:
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6. A compound having the formula:
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10. A compound having the formula:
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11. A compound having the formula:
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12. A compound having the structure:
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13. A compound having the formula:
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14. A compound having the formula:
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